Author results

6AQF
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CRYSTAL STRUCTURE OF A2AAR-BRIL IN COMPLEX WITH THE ANTAGONIST ZM241385 PRODUCED FROM PICHIA PASTORIS
分子名称:Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, CHOLESTEROL, ...
著者Eddy, M.T., Lee, M.Y., Gao, Z., White, K., Didenko, T., Horst, R., Audet, M., Stanczak, P., McClary, K.M., Han, G.W., Jacobson, K.A., Stevens, R.C., Wuthrich, K.
登録日2017-08-19
公開日2018-01-10
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor.
Cell, 172, 2018
6B73
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CRYSTAL STRUCTURE OF A NANOBODY-STABILIZED ACTIVE STATE OF THE KAPPA-OPIOID RECEPTOR
分子名称:Soluble cytochrome b562, kappa-type opioid receptor, Nanobody, ...
著者Che, T., Majumdar, S., Zaidi, S.A., Kormos, C., McCorvy, J.D., Wang, S., Mosier, P.D., Uprety, R., Vardy, E., Krumm, B.E., Han, G.W., Lee, M.Y., Pardon, E., Steyaert, J., Huang, X.P., Strachan, R.T., Tribo, A.R., Pasternak, G.W., Carroll, I.F., Stevens, R.C., Cherezov, V., Katritch, V., Wacker, D., Roth, B.L.
登録日2017-10-03
公開日2018-01-17
最終更新日2019-11-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Cell, 172, 2018
6BD4
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CRYSTAL STRUCTURE OF HUMAN APO-FRIZZLED4 RECEPTOR
分子名称:Frizzled-4/Rubredoxin chimeric protein, ZINC ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
著者Yang, S., Wu, Y., Pu, M., Chen, Y., Dong, S., Guo, Y., Han, G.Y., Stevens, R.C., Zhao, S., Xu, F.
登録日2017-10-21
公開日2018-08-22
最終更新日2018-09-12
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
6BQG
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CRYSTAL STRUCTURE OF 5-HT2C IN COMPLEX WITH ERGOTAMINE
分子名称:5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, Ergotamine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
著者Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.
登録日2017-11-27
公開日2018-02-14
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
6BQH
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CRYSTAL STRUCTURE OF 5-HT2C IN COMPLEX WITH RITANSERIN
分子名称:5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
著者Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.
登録日2017-11-27
公開日2018-02-14
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
6M9T
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CRYSTAL STRUCTURE OF EP3 RECEPTOR BOUND TO MISOPROSTOL-FA
分子名称:Prostaglandin E2 receptor EP3 subtype, Endolysin chimera, (11alpha,12alpha,13E,16S)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid, ...
著者Audet, M., White, K.L., Breton, B., Zarzycka, B., Han, G.W., Lu, Y., Gati, C., Batyuk, A., Popov, P., Velasquez, J., Manahan, D., Hu, H., Weierstall, U., Liu, W., Shui, W., Katrich, V., Cherezov, V., Hanson, M.A., Stevens, R.C.
登録日2018-08-24
公開日2018-12-05
最終更新日2019-02-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor.
Nat. Chem. Biol., 15, 2019
6MTG
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A SINGLE REACTIVE NONCANONICAL AMINO ACID IS ABLE TO DRAMATICALLY STABILIZE PROTEIN STRUCTURE
分子名称:Homoserine O-succinyltransferase, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ...
著者Li, J.C., Nasertorabi, F., Xuan, W., Han, G.W., Stevens, R.C., Schultz, P.G.
登録日2018-10-19
公開日2019-06-26
最終更新日2019-07-10
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure.
Acs Chem.Biol., 14, 2019
6PAH
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HUMAN PHENYLALANINE HYDROXYLASE CATALYTIC DOMAIN DIMER WITH BOUND L-DOPA (3,4-DIHYDROXYPHENYLALANINE) INHIBITOR
分子名称:PHENYLALANINE 4-MONOOXYGENASE, FE (III) ION, 3,4-DIHYDROXYPHENYLALANINE
著者Erlandsen, H., Flatmark, T., Stevens, R.C.
登録日1998-08-20
公開日1999-04-27
最終更新日2011-08-31
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution.
Biochemistry, 37, 1998
6PT2
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CRYSTAL STRUCTURE OF THE ACTIVE DELTA OPIOID RECEPTOR IN COMPLEX WITH THE PEPTIDE AGONIST KGCHM07
分子名称:Delta opioid receptor, Peptide agonist KGCHM07, CHOLESTEROL, ...
著者Claff, T., Yu, J., Blais, V., Patel, N., Martin, C., Wu, L., Han, G.W., Holleran, B.J., Van der Poorten, O., Hanson, M.A., Sarret, P., Gendron, L., Cherezov, V., Katritch, V., Ballet, S., Liu, Z., Muller, C.E., Stevens, R.C.
登録日2019-07-14
公開日2019-12-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Elucidating the active delta-opioid receptor crystal structure with peptide and small-molecule agonists
Sci Adv, 5, 2019
6PT3
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CRYSTAL STRUCTURE OF THE ACTIVE DELTA OPIOID RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE AGONIST DPI-287
分子名称:Delta opioid receptor, 4-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazin-1-yl](3-hydroxyphenyl)methyl]-N,N-diethylbenzamide
著者Claff, T., Yu, J., Blais, V., Patel, N., Martin, C., Wu, L., Han, G.W., Holleran, B.J., Van der Poorten, O., Hanson, M.A., Sarret, P., Gendron, L., Cherezov, V., Katritch, V., Ballet, S., Liu, Z., Muller, C.E., Stevens, R.C.
登録日2019-07-14
公開日2019-12-11
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Elucidating the active delta-opioid receptor crystal structure with peptide and small-molecule agonists
Sci Adv, 5, 2019
5ER7
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CONNEXIN-26 BOUND TO CALCIUM
分子名称:Gap junction beta-2 protein, CALCIUM ION
著者Purdy, M.D., Bennett, B.C., Baker, K.A., Yeager, M.J.
登録日2015-11-13
公開日2016-01-27
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (3.286 Å)
主引用文献An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels.
Nat Commun, 7, 2016
5ERA
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HUMAN CONNEXIN-26 (CALCIUM-FREE)
分子名称:Gap junction beta-2 protein
著者Purdy, M.D., Bennett, B.C., Baker, K.A., Yeager, M.J.
登録日2015-11-13
公開日2016-01-27
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels.
Nat Commun, 7, 2016
1C7I
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THERMOPHYLIC PNB ESTERASE
分子名称:PROTEIN (PARA-NITROBENZYL ESTERASE), CALCIUM ION
著者Spiller, B., Gershenson, A., Arnold, F., Stevens, R.
登録日2000-02-21
公開日2000-03-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A structural view of evolutionary divergence.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QE3
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PNB ESTERASE
分子名称:PARA-NITROBENZYL ESTERASE, SULFATE ION, ZINC ION
著者Spiller, B., Gershenson, A., Arnold, F., Stevens, R.
登録日1999-07-12
公開日1999-07-21
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献A structural view of evolutionary divergence.
Proc.Natl.Acad.Sci.USA, 96, 1999
3QAK
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AGONIST BOUND STRUCTURE OF THE HUMAN ADENOSINE A2A RECEPTOR
分子名称:Adenosine receptor A2a,lysozyme chimera, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
著者Xu, F., Wu, H., Katritch, V., Han, G.W., Cherezov, V., Stevens, R., GPCR Network (GPCR)
登録日2011-01-11
公開日2011-03-09
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Structure of an agonist-bound human A2A adenosine receptor.
Science, 332, 2011
3RZE
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STRUCTURE OF THE HUMAN HISTAMINE H1 RECEPTOR IN COMPLEX WITH DOXEPIN
分子名称:Histamine H1 receptor, Lysozyme chimera, (3E)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine, ...
著者Shimamura, T., Han, G.W., Shiroishi, M., Weyand, S., Tsujimoto, H., Winter, G., Katritch, V., Abagyan, R., Cherezov, V., Liu, W., Kobayashi, T., Stevens, R., Iwata, S., GPCR Network (GPCR)
登録日2011-05-11
公開日2011-06-15
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of the human histamine H1 receptor complex with doxepin.
Nature, 475, 2011
4XNV
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THE HUMAN P2Y1 RECEPTOR IN COMPLEX WITH BPTU
分子名称:P2Y purinoceptor 1, Rubredoxin, 1-[2-(2-tert-butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea, ...
著者Zhang, D., Gao, Z., Jacobson, K., Han, G.W., Stevens, R., Zhao, Q., Wu, B., GPCR Network (GPCR)
登録日2015-01-16
公開日2015-04-01
最終更新日2015-04-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Two disparate ligand-binding sites in the human P2Y1 receptor
Nature, 520, 2015
4XNW
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THE HUMAN P2Y1 RECEPTOR IN COMPLEX WITH MRS2500
分子名称:P2Y purinoceptor 1,Rubredoxin,P2Y purinoceptor 1, [(1R,2S,4S,5S)-4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hex-1-yl]methyl dihydrogen phosphate, ZINC ION
著者Zhang, D., Gao, Z., Jacobson, K., Han, G.W., Stevens, R., Zhao, Q., Wu, B., GPCR Network (GPCR)
登録日2015-01-16
公開日2015-04-01
最終更新日2015-04-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Two disparate ligand-binding sites in the human P2Y1 receptor
Nature, 520, 2015
4ZJ2
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CRYSTAL STRUCTURE OF P-ACRYLAMIDO-PHENYLALANINE MODIFIED TEM1 BETA-LACTAMASE FROM ESCHERICHIA COLI :E166N MUTANT
分子名称:Beta-lactamase TEM
著者Xiao, H., Nasertorabi, F., Choi, S., Han, G.W., Reed, S.A., Stevens, C.S., Schultz, P.G.
登録日2015-04-28
公開日2015-05-20
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Exploring the potential impact of an expanded genetic code on protein function.
Proc.Natl.Acad.Sci.USA, 112, 2015
5XEZ
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STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR
分子名称:Glucagon receptor,Endolysin,Glucagon receptor, Antibody, mAb1, ...
著者Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
登録日2017-04-06
公開日2017-05-24
最終更新日2017-06-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
5XF1
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STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR
分子名称:Glucagon receptor,Endolysin,Glucagon receptor, Antibody mAb1 Heavy chain, Antibody mAb1 Light chain, ...
著者Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
登録日2017-04-06
公開日2017-05-24
最終更新日2017-06-14
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
5YQZ
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STRUCTURE OF THE GLUCAGON RECEPTOR IN COMPLEX WITH A GLUCAGON ANALOGUE
分子名称:Glucagon receptor,Endolysin,Glucagon receptor, Glucagon analogue, N-ACETYL-D-GLUCOSAMINE, ...
著者Zhang, H., Qiao, A., Yang, L., VAN EPS, N., Frederiksen, K., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Can, C., He, L., Yang, H., Lau, J., Ernst, O., Hanson, M., Stevens, R., Wang, M., Seedtz-Runge, S., Jiang, H., Zhao, Q., Wu, B.
登録日2017-11-08
公開日2018-01-17
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of the glucagon receptor in complex with a glucagon analogue.
Nature, 553, 2018
6EDR
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CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH 4'-THIORIBOSE NAD+
分子名称:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(3-aminocarbonylpyridin-1-yl)-3,4-bis(oxidanyl)thiolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
著者Dai, Z., Zhang, X.N., Nasertorabi, F., Cheng, Q., Pei, H., Louie, S.G., Stevens, C.R., Zhang, Y.
登録日2018-08-10
公開日2018-11-21
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Facile chemoenzymatic synthesis of a novel stable mimic of NAD.
Chem Sci, 9, 2018
1AT1
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CRYSTAL STRUCTURES OF PHOSPHONOACETAMIDE LIGATED T AND PHOSPHONOACETAMIDE AND MALONATE LIGATED R STATES OF ASPARTATE CARBAMOYLTRANSFERASE AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H
分子名称:ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
著者Gouaux, J.E., Lipscomb, W.N.
登録日1989-09-22
公開日1990-10-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of phosphonoacetamide ligated T and phosphonoacetamide and malonate ligated R states of aspartate carbamoyltransferase at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
2AT1
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CRYSTAL STRUCTURES OF PHOSPHONOACETAMIDE LIGATED T AND PHOSPHONOACETAMIDE AND MALONATE LIGATED R STATES OF ASPARTATE CARBAMOYLTRANSFERASE AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL PH
分子名称:ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
著者Gouaux, J.E., Lipscomb, W.N.
登録日1989-09-22
公開日1990-10-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of phosphonoacetamide ligated T and phosphonoacetamide and malonate ligated R states of aspartate carbamoyltransferase at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990