Author results

3B7X
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CRYSTAL STRUCTURE OF HUMAN FK506-BINDING PROTEIN 6
Descriptor:FK506-binding protein 6
Authors:Walker, J.R., Davis, T., Butler-Cole, C., Paramanathan, R., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human FK506-Binding Protein 6.
To be Published
3B7Y
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CRYSTAL STRUCTURE OF THE C2 DOMAIN OF THE E3 UBIQUITIN-PROTEIN LIGASE NEDD4
Descriptor:E3 ubiquitin-protein ligase NEDD4, CALCIUM ION
Authors:Walker, J.R., Ruzanov, M., Butler-Cole, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:C2 Domain of the Human E3 Ubiquitin-Protein Ligase NEDD4.
To be Published
3BFO
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CRYSTAL STRUCTURE OF IG-LIKE C2-TYPE 2 DOMAIN OF THE HUMAN MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1
Descriptor:Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Isoform 2)
Authors:Walker, J.R., Akutsu, M., Littler, D.R., Li, Y., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-11-22
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structure of the Ig-like C2-type 2 domain of the human Mucosa-associated lymphoid tissue lymphoma translocation protein 1.
To be Published
3BPR
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR C52
Descriptor:Proto-oncogene tyrosine-protein kinase MER, 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE, SODIUM ION, ...
Authors:Walker, J.R., Huang, X., Finerty Jr, P.J., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-12-19
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into the inhibited states of the Mer receptor tyrosine kinase.
J.Struct.Biol., 165, 2009
3BRB
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH ADP
Descriptor:Proto-oncogene tyrosine-protein kinase MER, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Walker, J.R., Huang, X., Finerty Jr, P.J., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-12-21
Release date:2008-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into the inhibited states of the Mer receptor tyrosine kinase.
J.Struct.Biol., 165, 2009
3C5K
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CRYSTAL STRUCTURE OF HUMAN HDAC6 ZINC FINGER DOMAIN
Descriptor:Histone deacetylase 6, ZINC ION
Authors:Dong, A., Ravichandran, M., Schuetz, A., Loppnau, P., Li, Y., MacKenzie, F., Kozieradzki, I., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Bountra, C., Bochkarev, A., Dhe-Paganon, S., Min, J., Ouyang, H., Structural Genomics Consortium (SGC)
Deposit date:2008-01-31
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal Structure of Human HDAC6 zinc finger domain.
To be Published
3C8X
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CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE
Descriptor:Ephrin type-A receptor 2
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Butler-Cole, C., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-02-14
Release date:2008-03-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
3CZU
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CRYSTAL STRUCTURE OF THE HUMAN EPHRIN A2- EPHRIN A1 COMPLEX
Descriptor:Ephrin type-A receptor 2, Ephrin-A1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Butler-Cole, C., Bountra, C., Wikstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-04-30
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
3DKM
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CRYSTAL STRUCTURE OF THE HECTD1 CPH DOMAIN
Descriptor:E3 ubiquitin-protein ligase HECTD1
Authors:Walker, J.R., Qiu, L., Li, Y., Bountra, C., Wolkstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-06-25
Release date:2008-08-19
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the CPH domain of the E3 ubiquitin-protein ligase HECTD1.
To be Published
3DKO
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COMPLEX BETWEEN THE KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7 (EPHA7) AND INHIBITOR ALW-II-49-7
Descriptor:Ephrin type-A receptor 7, 5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide
Authors:Walker, J.R., Syeda, F., Gray, N., Butler-Cole, C., Bountra, C., Wolkstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-06-25
Release date:2008-08-19
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Kinase domain of human ephrin type-a receptor 7 (epha7) in complex with ALW-II-49-7
To be Published
3DZQ
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HUMAN EPHA3 KINASE DOMAIN IN COMPLEX WITH INHIBITOR AWL-II-38.3
Descriptor:EPH receptor A3, N-[2-methyl-5-({[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]carbonyl}amino)phenyl]isoxazole-5-carboxamide
Authors:Walker, J.R., Syeda, F., Gray, N., Mansoor, W., Mackenzie, F., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-07-30
Release date:2008-08-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Kinase Domain of Human Ephrin Type-A Receptor 3 (Epha3) in Complex with ALW-II-38-3.
To be Published
3EBQ
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CRYSTAL STRUCTURE OF HUMAN PPPDE1
Descriptor:MOLECULE: PPPDE1 (PERMUTED PAPAIN FOLD PEPTIDASES OF DSRNA VIRUSES AND EUKARYOTES 1), UPF0326 protein FAM152B, MERCURY (II) ION
Authors:Walker, J.R., Akutsu, M., Qiu, L., Li, Y., Slessarev, Y., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Botchkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-08-28
Release date:2008-11-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Human PPPDE1
To be Published
3F0N
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MUS MUSCULUS MEVALONATE PYROPHOSPHATE DECARBOXYLASE
Descriptor:MEVALONATE PYROPHOSPHATE DECARBOXYLASE, PHOSPHATE ION
Authors:Walker, J.R., Davis, T., Vesterberg, A., Li, Y., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-10-25
Release date:2008-11-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Mus Musculus Mevalonate Pyrophosphate Decarboxylase
To be Published
3FL7
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CRYSTAL STRUCTURE OF THE HUMAN EPHRIN A2 ECTODOMAIN
Descriptor:Ephrin receptor, SODIUM ION, CHLORIDE ION, ...
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Butler-Cole, C., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-12-18
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
3FXX
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HUMAN EPHA3 KINASE AND JUXTAMEMBRANE REGION BOUND TO SUBSTRATE KQWDNYE[PTYR]IW
Descriptor:Ephrin type-A receptor 3, peptide substrate, MAGNESIUM ION, ...
Authors:Davis, T., Walker, J.R., Mackenzie, F., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-01-21
Release date:2009-02-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases.
Febs J., 276, 2009
3FY2
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HUMAN EPHA3 KINASE AND JUXTAMEMBRANE REGION BOUND TO SUBSTRATE KQWDNYEFIW
Descriptor:Ephrin type-A receptor 3, peptide substrate
Authors:Davis, T., Walker, J.R., Mackenzie, F., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-01-21
Release date:2009-02-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases.
Febs J., 276, 2009
3G1N
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CATALYTIC DOMAIN OF THE HUMAN E3 UBIQUITIN-PROTEIN LIGASE HUWE1
Descriptor:E3 ubiquitin-protein ligase HUWE1, SODIUM ION
Authors:Walker, J.R., Qiu, L., Li, Y., Davis, T., Tempel, W., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Botchkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-01-30
Release date:2009-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Hect Domain of Human HUWE1/MULE
To be Published
3GUC
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HUMAN UBIQUITIN-ACTIVATING ENZYME 5 IN COMPLEX WITH AMPPNP
Descriptor:Ubiquitin-like modifier-activating enzyme 5, ZINC ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Walker, J.R., Bacik, J.P., Li, Y., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-03-29
Release date:2009-05-26
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Human Ubiquitin-activating Enzyme 5 in Complex with AMPPNP
To be Published
3GV4
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CRYSTAL STRUCTURE OF HUMAN HDAC6 ZINC FINGER DOMAIN AND UBIQUITIN C-TERMINAL PEPTIDE RLRGG
Descriptor:Histone deacetylase 6, ubiquitin C-terminal peptide RLRGG, ZINC ION, ...
Authors:Dong, A., Ravichandran, M., Loppnau, P., Li, Y., MacKenzie, F., Kozieradzki, I., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Bountra, C., Bochkarev, A., Dhe-Paganon, S., Min, J., Ouyang, H., Structural Genomics Consortium (SGC)
Deposit date:2009-03-30
Release date:2009-04-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG
To be Published
3H8M
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SAM DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7 (EPHA7)
Descriptor:Ephrin type-A receptor 7
Authors:Walker, J.R., Yermekbayeva, L., Butler-Cole, C., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-04-29
Release date:2009-05-26
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:SAM Domain of Human Ephrin Type-A Receptor 7 (Epha7)
To be Published
3H8V
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HUMAN UBIQUITIN-ACTIVATING ENZYME 5 IN COMPLEX WITH ATP
Descriptor:Ubiquitin-like modifier-activating enzyme 5, ZINC ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Walker, J.R., Bacik, J.P., Rastgoo, N., Weigelt, J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-04-29
Release date:2009-05-26
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme.
J.Biol.Chem., 285, 2010
3HIL
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SAM DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 1 (EPHA1)
Descriptor:Ephrin type-A receptor 1, CHLORIDE ION, NITRATE ION
Authors:Walker, J.R., Yermekbayeva, L., Butler-Cole, C., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-05-20
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:SAM Domain of Human Ephrin Type-A Receptor 1 (EphA1).
To be Published
3I2V
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CRYSTAL STRUCTURE OF HUMAN MOCS3 RHODANESE-LIKE DOMAIN
Descriptor:Adenylyltransferase and sulfurtransferase MOCS3
Authors:Bacik, J.P., Walker, J.R., Lopez, L., Li, Y., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-06-29
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal structure of the human MOCS3 rhodanese-like domain
To be Published
3ICU
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PROTEASE-ASSOCIATED DOMAIN OF THE E3 LIGASE GRAIL
Descriptor:E3 ubiquitin-protein ligase RNF128, N-ACETYL-D-GLUCOSAMINE
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-07-18
Release date:2009-09-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:PA Domain of the E3 Ligase Grail
To be Published
3K0W
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CRYSTAL STRUCTURE OF THE TANDEM IG-LIKE C2-TYPE 2 DOMAINS OF THE HUMAN MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1
Descriptor:Mucosa-associated lymphoid tissue lymphoma translocation protein 1, isoform 2, CHLORIDE ION
Authors:Walker, J.R., Qiu, L., Butler-Cole, C., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-09-25
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Tandem Ig-Like C2-Type 2 Domains of the Human Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1.
To be Published