Author results

4QN1
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CRYSTAL STRUCTURE OF A FUNCTIONALLY UNCHARACTERIZED DOMAIN OF E3 UBIQUITIN LIGASE SHPRH
Descriptor:E3 ubiquitin-protein ligase SHPRH, ZINC ION, SULFATE ION, ...
Authors:Dong, A., Zhang, Q., Li, Y., Walker, J.R., Guan, X., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2014-06-17
Release date:2014-08-13
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal structure of a Function Uncharacterized Domain of E3 Ubiquitin Ligase SHPRH
To be Published
4TVR
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TANDEM TUDOR AND PHD DOMAINS OF UHRF2
Descriptor:E3 ubiquitin-protein ligase UHRF2, ZINC ION, UNKNOWN ATOM OR ION
Authors:Walker, J.R., Dong, A., Zhang, Q., Ong, M., Duan, S., Li, Y., Bountra, C., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2015-06-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure of the Tandem Tudor and PHD domains of UHRF2
To be published
4QT6
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CRYSTAL STRUCTURE OF THE SPRY DOMAIN OF HUMAN HERC1
Descriptor:Probable E3 ubiquitin-protein ligase HERC1, FORMAMIDE, UNKNOWN ATOM OR ION
Authors:Dong, A., Hu, J., Guan, X., Wernimont, A., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2014-07-07
Release date:2015-01-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Crystal structure of the SPRY domain of human HERC1
To be Published
4X3G
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CRYSTAL STRUCTURE OF SIAH1 SINA DOMAIN IN COMPLEX WITH A USP19 PEPTIDE
Descriptor:E3 ubiquitin-protein ligase SIAH1, Ubiquitin carboxyl-terminal hydrolase 19, ZINC ION
Authors:Walker, J.R., Dong, A., Zhang, Q., Huang, X., Li, Y., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2014-11-28
Release date:2014-12-31
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystal structure of SIAH1 SINA domain in complex with a USP19 peptide
To be published
4RXX
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN UBIQUITIN SPECIFIC PROTEASE 38
Descriptor:Ubiquitin carboxyl-terminal hydrolase 38, CHLORIDE ION, 1,2-ETHANEDIOL, ...
Authors:Dong, A., Shen, L., Hu, J., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2014-12-12
Release date:2015-01-21
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal Structure of the N-terminal Domain of Human Ubiquitin Specific Protease 38
to be published
4YWQ
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CRYSTAL STRUCTURE OF THE ROQ DOMAIN OF HUMAN ROQUIN-1
Descriptor:Roquin-1, ZINC ION, GLYCEROL, ...
Authors:Dong, A., Zhang, Q., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-03-20
Release date:2015-04-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the ROQ domain of human Roquin-1
To be Published
4Z30
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CRYSTAL STRUCTURE OF THE ROQ DOMAIN OF HUMAN ROQUIN-2
Descriptor:Roquin-2, UNKNOWN ATOM OR ION
Authors:DONG, A., ZHANG, Q., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-03-30
Release date:2015-10-14
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
Sci Rep, 5, 2015
4Z31
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CRYSTAL STRUCTURE OF THE RC3H2 ROQ DOMAIN IN COMPLEX WITH STEM-LOOP AND DOUBLE-STRANDED FORMS OF RNA
Descriptor:Roquin-2, RNA (5'-R(*A)-D(P*UP*GP*UP*UP*CP*UP*GP*UP*GP*AP*AP*CP*AP*C)-3'), UNKNOWN ATOM OR ION, ...
Authors:DONG, A., ZHANG, Q., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-03-30
Release date:2015-10-14
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
Sci Rep, 5, 2015
5C7J
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CRYSTAL STRUCTURE OF NEDD4 WITH A UB VARIANT
Descriptor:E3 ubiquitin-protein ligase NEDD4, Polyubiquitin-C
Authors:Walker, J.R., Hu, J., Dong, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-06-24
Release date:2016-03-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5C7M
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CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT
Descriptor:E3 ubiquitin-protein ligase Itchy homolog, Polyubiquitin-C
Authors:Walker, J.R., Hu, J., Dong, A., Wernimont, A., Zhang, W., Sidhu, S., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-06-24
Release date:2016-03-16
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5H9M
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CRYSTAL STRUCTURE OF SIAH2 SBD DOMAIN
Descriptor:E3 ubiquitin-protein ligase SIAH2, ZINC ION, CHLORIDE ION, ...
Authors:Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-12-28
Release date:2016-02-17
Method:X-RAY DIFFRACTION (1.761 Å)
Cite:Crystal structure of siah2 SBD domain
to be published
5HPK
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SYSTEM-WIDE MODULATION OF HECT E3 LIGASES WITH SELECTIVE UBIQUITIN VARIANT PROBES: NEDD4L AND UBV NL.1
Descriptor:E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin variant NL.1
Authors:Wu, K.-P., Mukherjee, M., Mercredi, P.Y., Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.431 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPL
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SYSTEM-WIDE MODULATION OF HECT E3 LIGASES WITH SELECTIVE UBIQUITIN VARIANT PROBES: RSP5 AND UBV R5.4
Descriptor:Rsp5, Ubiquitin variant R5.4
Authors:Wu, K.-P., Kamadurai, H.B., Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPS
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SYSTEM-WIDE MODULATION OF HECT E3 LIGASES WITH SELECTIVE UBIQUITIN VARIANT PROBES: WWP1 AND UBV P1.1
Descriptor:WWP1 HECT, Ubiquitin variant P1.1
Authors:Wu, K.-P., Mercredi, P.Y., Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPT
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SYSTEM-WIDE MODULATION OF HECT E3 LIGASES WITH SELECTIVE UBIQUITIN VARIANT PROBES: WWP1, UBV P2.3 AND UBCH7
Descriptor:NEDD4-like E3 ubiquitin-protein ligase WWP1, Ubiquitin variant P2.3, Ubiquitin-conjugating enzyme E2 L3
Authors:Wu, K.-P., Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5JJW
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CRYSTAL STRUCTURE OF THE HAT DOMAIN OF SART3 IN COMPLEX WITH USP15 DUSP-UBL DOMAIN
Descriptor:Squamous cell carcinoma antigen recognized by T-cells 3, Ubiquitin carboxyl-terminal hydrolase 15, 1,2-ETHANEDIOL, ...
Authors:Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2016-04-25
Release date:2016-05-04
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain
to be published
5JJX
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CRYSTAL STRUCTURE OF THE HAT DOMAIN OF SART3
Descriptor:Squamous cell carcinoma antigen recognized by T-cells 3, CHLORIDE ION, UNKNOWN ATOM OR ION
Authors:DONG, A., ZHANG, Q., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2016-04-25
Release date:2016-05-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the HAT domain of sart3
to be published
5TF2
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CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN
Descriptor:Prolactin regulatory element-binding protein, UNKNOWN ATOM OR ION
Authors:Walker, J.R., Zhang, Q., Dong, A., Wernimont, A., Li, Y., He, H., Tempel, W., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Chen, Z., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2016-09-23
Release date:2016-11-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN (CASP target)
To be published
5WRV
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COMPLEX STRUCTURE OF HUMAN SRP72/SRP68
Descriptor:Signal recognition particle subunit SRP68, Signal recognition particle subunit SRP72, ACETATE ION, ...
Authors:Gao, Y., Chen, Z.
Deposit date:2016-12-04
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
5WRW
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STRUCTURE OF HUMAN APO-SRP72
Descriptor:Signal recognition particle subunit SRP72, SULFATE ION
Authors:Gao, Y., Chen, Z.
Deposit date:2016-12-04
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
5ULO
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CRYSTAL STRUCTURE OF 14-3-3 ZETA IN COMPLEX WITH A SERINE 124-PHOSPHORYLATED TBC1D7 PEPTIDE
Descriptor:14-3-3 protein zeta/delta, TBC1 domain family member 7, 1,2-ETHANEDIOL, ...
Authors:DONG, A., HU, J., MADIGAN, J., WALKER, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-01-25
Release date:2018-01-31
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide
to be published
5VBD
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CRYSTAL STRUCTURE OF A PUTATIVE UBL DOMAIN OF USP9X
Descriptor:USP9X, UNKNOWN ATOM OR ION
Authors:Dong, A., Chern, Y., Hou, F., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-03-29
Release date:2017-04-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of a putative UBL domain of USP9X
to be published
5VBT
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CRYSTAL STRUCTURE OF A HIGHLY SPECIFIC AND POTENT USP7 UBIQUITIN VARIANT INHIBITOR
Descriptor:UBH04
Authors:DONG, A., DONG, X., LIU, L., GUO, Y., LI, Y., ZHANG, W., WALKER, J.R., SIDHU, S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-03-30
Release date:2017-06-07
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Crystal structure of a highly specific and potent USP7 ubiquitin variant inhibitor
to be published
5WCH
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN USP9X
Descriptor:Probable ubiquitin carboxyl-terminal hydrolase FAF-X, ZINC ION, UNKNOWN ATOM OR ION
Authors:Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5YYL
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STRUCTURE OF MAJOR ROYAL JELLY PROTEIN 1 OLIGOMER
Descriptor:Major royal jelly protein 1, Apisimin, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Tian, W., Chen, Z.
Deposit date:2017-12-10
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Architecture of the native major royal jelly protein 1 oligomer.
Nat Commun, 9, 2018