Author results

6KIW
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CRYO-EM STRUCTURE OF HUMAN MLL3-UBNCP COMPLEX (4.0 ANGSTROM)
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Huang, J., Xue, H., Yao, T.
Deposit date:2019-07-20
Release date:2019-09-11
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
6KIX
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CRYO-EM STRUCTURE OF HUMAN MLL1-NCP COMPLEX, BINDING MODE1
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Huang, J., Xue, H., Yao, T.
Deposit date:2019-07-20
Release date:2019-09-11
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
6KIZ
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CRYO-EM STRUCTURE OF HUMAN MLL1-NCP COMPLEX, BINDING MODE2
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Huang, J., Xue, H., Yao, T.
Deposit date:2019-07-20
Release date:2019-09-11
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
6LI0
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CRYSTAL STRUCTURE OF GPR52 IN COMPLEX WITH AGONIST C17
Descriptor:Chimera of G-protein coupled receptor 52 and Flavodoxin, N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide, FLAVIN MONONUCLEOTIDE, ...
Authors:Luo, Z.P., Lin, X., Xu, F., Han, G.W.
Deposit date:2019-12-10
Release date:2020-02-26
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of ligand recognition and self-activation of orphan GPR52.
Nature, 579, 2020
6LI1
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CRYSTAL STRUCTURE OF GPR52 LIGAND FREE FORM WITH FLAVODOXIN FUSION
Descriptor:Chimera of G-protein coupled receptor 52 and Flavodoxin, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FLAVIN MONONUCLEOTIDE, ...
Authors:Luo, Z.P., Lin, X., Xu, F., Han, G.W.
Deposit date:2019-12-10
Release date:2020-02-26
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of ligand recognition and self-activation of orphan GPR52.
Nature, 579, 2020
6LI2
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CRYSTAL STRUCTURE OF GPR52 LIGAND FREE FORM WITH RUBREDOXIN FUSION
Descriptor:Chimera of G-protein coupled receptor 52 and Rubredoxin, ZINC ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Luo, Z.P., Lin, X., Xu, F., Han, G.W.
Deposit date:2019-12-10
Release date:2020-02-26
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of ligand recognition and self-activation of orphan GPR52.
Nature, 579, 2020
2HY8
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PAK1 COMPLEX WITH ST2001
Descriptor:Serine/threonine-protein kinase PAK 1, (5S,6R,7R,9R)-12-HYDROXY-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE
Authors:Schulze-Gahmen, U., Lu, H.
Deposit date:2006-08-04
Release date:2006-11-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Complex Between Human Pak1-kinase and 3-Hydroxystaurosporine
To be Published
4NW3
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CRYSTAL STRUCTURE OF MLL CXXC DOMAIN IN COMPLEX WITH A CPG DNA
Descriptor:Histone-lysine N-methyltransferase 2A, 5'-D(*GP*CP*CP*AP*TP*CP*GP*AP*TP*GP*GP*C)-3', ZINC ION
Authors:Bian, C., Tempel, W., Chao, X., Walker, J.R., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2013-12-05
Release date:2014-04-23
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 2017
4O64
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ZINC FINGERS OF KDM2B
Descriptor:Lysine-specific demethylase 2B, ZINC ION, UNKNOWN ATOM OR ION
Authors:Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2013-12-20
Release date:2014-04-16
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 2017
4PZI
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ZINC FINGER REGION OF MLL2 IN COMPLEX WITH CPG DNA
Descriptor:Histone-lysine N-methyltransferase 2B, DNA (5'-D(*GP*CP*CP*AP*CP*CP*GP*GP*TP*GP*GP*C)-3'), ZINC ION, ...
Authors:Chao, X., Tempel, W., Liu, K., Dong, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2014-03-31
Release date:2014-06-04
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 2017
4QQG
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CRYSTAL STRUCTURE OF AN N-TERMINAL HTATIP FRAGMENT
Descriptor:Histone acetyltransferase KAT5, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Wernimont, A.K., Dobrovetsky, E., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2014-07-09
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and histone binding studies of the chromo barrel domain of TIP60.
FEBS Lett., 592, 2018
4WVS
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CRYSTAL STRUCTURE OF XIAP-BIR2 DOMAIN COMPLEXED WITH (S)-3-(4-METHOXYPHENYL)-2-((S)-2-((S)-1-((S)-2-((S)-2-(METHYLAMINO)PROPANAMIDO)PENT-4-YNOYL)PYRROLIDINE-2-CARBOXAMIDO)-3-PHENYLPROPANAMIDO)PROPANOIC ACID
Descriptor:E3 ubiquitin-protein ligase XIAP, 3,11-DIFLUORO-6,8,13-TRIMETHYL-8H-QUINO[4,3,2-KL]ACRIDIN-13-IUM, ZINC ION, ...
Authors:Pokross, M.E.
Deposit date:2014-11-07
Release date:2015-05-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity.
J.Med.Chem., 58, 2015
4WVT
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CRYSTAL STRUCTURE OF XIAP-BIR2 DOMAIN COMPLEXED WITH LIGAND BOUND
Descriptor:E3 ubiquitin-protein ligase XIAP, 3,11-DIFLUORO-6,8,13-TRIMETHYL-8H-QUINO[4,3,2-KL]ACRIDIN-13-IUM, ZINC ION
Authors:Pokross, M.E.
Deposit date:2014-11-07
Release date:2015-03-04
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity.
J.Med.Chem., 58, 2015
4WVU
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CRYSTAL STRUCTURE OF XIAP-BIR2 DOMAIN COMPLEXED WITH LIGAND BOUND
Descriptor:E3 ubiquitin-protein ligase XIAP, 3,11-DIFLUORO-6,8,13-TRIMETHYL-8H-QUINO[4,3,2-KL]ACRIDIN-13-IUM, ZINC ION, ...
Authors:Pokross, M.E.
Deposit date:2014-11-07
Release date:2015-03-04
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity.
J.Med.Chem., 58, 2015
4Z3C
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ZINC FINGER REGION OF HUMAN TET3 IN COMPLEX WITH CPG DNA
Descriptor:DNA (5'-D(*GP*CP*CP*AP*AP*CP*GP*TP*TP*GP*GP*C)-3'), Methylcytosine dioxygenase, UNKNOWN ATOM OR ION, ...
Authors:Liu, K., Xu, C., Tempel, W., Dong, A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2015-03-31
Release date:2015-04-29
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 2017
5T1I
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CBX3 CHROMO SHADOW DOMAIN IN COMPLEX WITH HISTONE H3 PEPTIDE
Descriptor:Chromobox protein homolog 3, Histone H3.1, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2016-08-19
Release date:2016-09-14
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1.
J. Biol. Chem., 292, 2017
5VC9
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ZINC FINGER OF HUMAN CXXC4 IN COMPLEX WITH CPG DNA
Descriptor:CpG DNA, CXXC-type zinc finger protein 4, UNKNOWN ATOM OR ION, ...
Authors:Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-03-31
Release date:2017-06-28
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
5VFC
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WDR5 BOUND TO INHIBITOR MM-589
Descriptor:WD repeat-containing protein 5, N-{(3R,6S,9S,12R)-6-ethyl-12-methyl-9-[3-(N'-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl}-2-methylpropanamide, SULFATE ION, ...
Authors:Stuckey, J.A.
Deposit date:2017-04-07
Release date:2017-06-28
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J. Med. Chem., 60, 2017
5W9Q
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ZINC FINGER REGION OF MBD1 IN COMPLEX WITH CPG DNA
Descriptor:Methyl-CpG-binding domain protein 1, dna, ZINC ION, ...
Authors:Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-06-23
Release date:2017-10-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
5W9S
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ZINC FINGER OF HUMAN CXXC5 IN COMPLEX WITH CPG DNA
Descriptor:CpG DNA fragment, CXXC-type zinc finger protein 5, ZINC ION, ...
Authors:Liu, K., Xu, C., Tempel, W., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-06-23
Release date:2017-10-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
5XYF
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CRYSTAL STRUCTURE OF THE HUMAN TIN2-TPP1-TRF2 TELOMERIC COMPLEX
Descriptor:TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 2, Adrenocortical dysplasia protein homolog
Authors:Hu, C., Chen, Y.
Deposit date:2017-07-07
Release date:2017-12-13
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex.
Cell Res., 27, 2017
6ASB
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CXXC AND PHD-TYPE ZINC FINGER REGIONS OF FBXL19 IN COMPLEX WITH DNA
Descriptor:DNA (5'-D(*GP*CP*CP*AP*AP*CP*GP*TP*TP*GP*GP*C)-3'), F-box/LRR-repeat protein 19, ZINC ION
Authors:Liu, K., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-08-24
Release date:2017-10-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
6ASD
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ZINC FINGER REGION OF HUMAN TET1 IN COMPLEX WITH CPG DNA
Descriptor:DNA (5'-D(*GP*CP*CP*AP*CP*CP*GP*GP*TP*GP*GP*C)-3'), Methylcytosine dioxygenase TET1, UNKNOWN ATOM OR ION, ...
Authors:Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-08-24
Release date:2017-10-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
6C1A
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MBD2 IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, dna strand 1, complement to dna strand 1, ...
Authors:Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-04
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6CC8
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CRYSTAL STRUCTURE MBD3 MBD DOMAIN IN COMPLEX WITH METHYLATED CPG DNA
Descriptor:Methyl-CpG-binding domain protein 3, methylated CpG DNA, UNKNOWN ATOM OR ION
Authors:Liu, K., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-06
Release date:2018-04-04
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 286, 2019
167132
数据于2020-07-29公开中