Author results

5HXW
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L-AMINO ACID DEAMINASE FROM PROTEUS VULGARIS
分子名称:L-amino acid deaminase, FLAVIN-ADENINE DINUCLEOTIDE, CETYL-TRIMETHYL-AMMONIUM
著者Zhou, H., Ju, Y., Niu, L., Teng, M.
登録日2016-01-31
公開日2016-08-03
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Crystal structure of a membrane-bound l-amino acid deaminase from Proteus vulgaris
J.Struct.Biol., 195, 2016
5I39
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HIGH RESOLUTION STRUCTURE OF L-AMINO ACID DEAMINASE FROM PROTEUS VULGARIS WITH THE DELETION OF THE SPECIFIC INSERTION SEQUENCE
分子名称:L-amino acid deaminase, FLAVIN-ADENINE DINUCLEOTIDE, 1,2-ETHANEDIOL
著者Zhou, H., Ju, Y., Niu, L., Teng, M.
登録日2016-02-10
公開日2016-08-03
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal structure of a membrane-bound l-amino acid deaminase from Proteus vulgaris
J.Struct.Biol., 195, 2016
5XLT
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THE CRYSTAL STRUCTURE OF TUBULIN IN COMPLEX WITH 4'-DEMETHYLEPIPODOPHYLLOTOXIN
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Yu, Y., Chen, Q.
登録日2017-05-11
公開日2017-09-27
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.813 Å)
主引用文献Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design
Biochem. Biophys. Res. Commun., 493, 2017
3B9C
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CRYSTAL STRUCTURE OF HUMAN GRP CRD
分子名称:HSPC159, SULFATE ION, BETA-MERCAPTOETHANOL
著者Zhou, D., Ge, H.H., Niu, L.W., Teng, M.K.
登録日2007-11-05
公開日2008-03-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the C-terminal conserved domain of human GRP, a galectin-related protein, reveals a function mode different from those of galectins.
Proteins, 71, 2008
3DXX
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CRYSTAL STRUCTURE OF ECTRMB
分子名称:tRNA (guanine-N(7)-)-methyltransferase, GLYCEROL
著者Zhou, H.H., Liu, Q., Gao, Y.X., Teng, M.K., Niu, L.W.
登録日2008-07-25
公開日2009-05-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion
Proteins, 76, 2009
3DXY
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CRYSTAL STRUCTURE OF ECTRMB IN COMPLEX WITH SAM
分子名称:tRNA (guanine-N(7)-)-methyltransferase, SULFATE ION, S-ADENOSYLMETHIONINE, ...
著者Zhou, H.H., Liu, Q., Gao, Y.X., Teng, M.K., Niu, L.W.
登録日2008-07-25
公開日2009-05-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion
Proteins, 76, 2009
3DXZ
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CRYSTAL STRUCTURE OF ECTRMB IN COMPLEX WITH SAH
分子名称:tRNA (guanine-N(7)-)-methyltransferase, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Zhou, H.H., Liu, Q., Gao, Y.X., Teng, M.K., Niu, L.W.
登録日2008-07-25
公開日2009-05-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion
Proteins, 76, 2009
3E17
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CRYSTAL STRUCTURE OF THE SECOND PDZ DOMAIN FROM HUMAN ZONA OCCLUDENS-2
分子名称:Tight junction protein ZO-2
著者Chen, H., Tong, S.L., Teng, M.K., Niu, L.W.
登録日2008-08-01
公開日2009-07-21
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of the second PDZ domain from human zonula occludens 2
Acta Crystallogr.,Sect.F, 65, 2009
3HDB
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CRYSTAL STRUCTURE OF AAHIV, A METALLOPROTEINASE FROM VENOM OF AGKISTRODON ACUTUS
分子名称:AAHIV, KNL, ZINC ION, ...
著者Zhu, Z.Q., Niu, L.W., Teng, M.K.
登録日2009-05-07
公開日2009-08-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Structural basis of the autolysis of AaHIV suggests a novel target recognizing model for ADAM/reprolysin family proteins
Biochem.Biophys.Res.Commun., 386, 2009
1XX5
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CRYSTAL STRUCTURE OF NATRIN FROM NAJA ATRA SNAKE VENOM
分子名称:Natrin 1, ETHANOL
著者Wang, J., Shen, B., Lou, X.H., Guo, M., Teng, M.K., Niu, L.W.
登録日2004-11-04
公開日2005-06-14
最終更新日2014-12-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from Naja atra venom that targets the BKCa channel
Biochemistry, 44, 2005
4IZY
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CRYSTAL STRUCTURE OF JNK1 IN COMPLEX WITH JIP1 PEPTIDE AND 4-{4-[4-(4-METHANESULFONYL-PIPERIDIN-1-YL)-INDOL-1-YL]-PYRIMIDIN-2-YLAMINO}-CYCLOHEXAN
分子名称:Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, trans-4-[(4-{4-[4-(methylsulfonyl)piperidin-1-yl]-1H-indol-1-yl}pyrimidin-2-yl)amino]cyclohexanol
著者Kuglstatter, A., Shao, A.
登録日2013-01-30
公開日2013-12-18
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.
Bioorg.Med.Chem.Lett., 23, 2013
1ND1
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AMINO ACID SEQUENCE AND CRYSTAL STRUCTURE OF BAP1, A METALLOPROTEINASE FROM BOTHROPS ASPER SNAKE VENOM THAT EXERTS MULTIPLE TISSUE-DAMAGING ACTIVITIES.
分子名称:BaP1, ZINC ION
著者Watanabe, L., Shannon, J.D., Valente, R.H., Rucavado, A., Alape-Giron, A., Kamiguti, A.S., Theakston, R.D., Fox, J.W., Gutierrez, J.M., Arni, R.K.
登録日2002-12-06
公開日2003-11-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities
Protein Sci., 12, 2003
4FZ7
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CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE COMPLEXED WITH 6-((1R,2S)-2-AMINO-CYCLOHEXYLAMINO)-4-(6-ETHYL-PYRIDIN-2-YLAMINO)-PYRIDAZINE-3-CARBOXYLIC ACID AMIDE
分子名称:Tyrosine-protein kinase SYK, 6-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(6-ethylpyridin-2-yl)amino]pyridazine-3-carboxamide
著者Kuglstatter, A., Slade, M.
登録日2012-07-06
公開日2013-07-10
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors.
J. Med. Chem., 57, 2014
4HYS
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CRYSTAL STRUCTURE OF JNK1 IN COMPLEX WITH JIP1 PEPTIDE AND 4-(4-INDAZOL-1-YL-PYRIMIDIN-2-YLAMINO)-CYCLOHEXAN
分子名称:Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, trans-4-{[4-(1H-indazol-1-yl)pyrimidin-2-yl]amino}cyclohexanol
著者Kuglstatter, A., Janson, C.
登録日2012-11-14
公開日2013-10-30
実験手法X-RAY DIFFRACTION (2.415 Å)
主引用文献Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.
Bioorg.Med.Chem.Lett., 23, 2013
4HYU
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CRYSTAL STRUCTURE OF JNK1 IN COMPLEX WITH JIP1 PEPTIDE AND 4-{4-[4-(3-METHANESULFONYL-PROPOXY)-INDAZOL-1-YL]-PYRIMIDIN-2-YLAMINO}-CYCLOHEXAN
分子名称:Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, trans-4-[(4-{4-[3-(methylsulfonyl)propoxy]-1H-indazol-1-yl}pyrimidin-2-yl)amino]cyclohexanol
著者Kuglstatter, A., Ghate, M.
登録日2012-11-14
公開日2013-10-30
実験手法X-RAY DIFFRACTION (2.152 Å)
主引用文献Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.
Bioorg.Med.Chem.Lett., 23, 2013
4QT1
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JAK3 KINASE DOMAIN IN COMPLEX WITH 1-[(3S)-1-ISOBUTYLSULFONYL-3-PIPERIDYL]-3-(5H-PYRROLO[2,3-B]PYRAZIN-2-YL)UREA
分子名称:Tyrosine-protein kinase JAK3, 1-{(3S)-1-[(2-methylpropyl)sulfonyl]piperidin-3-yl}-3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)urea
著者Kuglstatter, A., Shao, A.
登録日2014-07-07
公開日2015-05-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Scaffold hopping towards potent and selective JAK3 inhibitors: discovery of novel C-5 substituted pyrrolopyrazines
Bioorg.Med.Chem.Lett., 24, 2014
6FWB
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CRYSTAL STRUCTURE OF MAT2A AT 1.79 ANGSTRON RESOLUTION
分子名称:S-adenosylmethionine synthase isoform type-2, SULFATE ION, TETRAETHYLENE GLYCOL, ...
著者Zhou, A., Wei, Z., Bai, J., Wang, H.
登録日2018-03-06
公開日2019-03-27
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.
Ebiomedicine, 39, 2019
1GPH
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STRUCTURE OF THE ALLOSTERIC REGULATORY ENZYME OF PURINE BIOSYNTHESIS
分子名称:GLUTAMINE PHOSPHORIBOSYL-PYROPHOSPHATE AMIDOTRANSFERASE, IRON/SULFUR CLUSTER, ADENOSINE MONOPHOSPHATE
著者Smith, J.L.
登録日1994-04-20
公開日1994-07-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of the allosteric regulatory enzyme of purine biosynthesis.
Science, 264, 1994
2OIB
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CRYSTAL STRUCTURE OF IRAK4 KINASE DOMAIN APO FORM
分子名称:Interleukin-1 receptor-associated kinase 4
著者Kuglstatter, A., Villasenor, A.G., Browner, M.F.
登録日2007-01-10
公開日2007-03-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
J.Immunol., 178, 2007
2OIC
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CRYSTAL STRUCTURE OF IRAK4 KINASE DOMAIN COMPLEXED WITH STAUROSPORINE
分子名称:Interleukin-1 receptor-associated kinase 4, STAUROSPORINE
著者Kuglstatter, A., Villasenor, A.G., Browner, M.F.
登録日2007-01-10
公開日2007-03-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
J.Immunol., 178, 2007
2OID
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CRYSTAL STRUCTURE OF IRAK4 KINASE DOMAIN COMPLEXED WITH AMPPNP
分子名称:Interleukin-1 receptor-associated kinase 4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Kuglstatter, A., Villasenor, A.G., Browner, M.F.
登録日2007-01-10
公開日2007-03-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
J.Immunol., 178, 2007
3GYO
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SE-MET RTT106P
分子名称:Histone chaperone RTT106
著者Liu, Y., Huang, H., Shi, Y., Teng, M.
登録日2009-04-04
公開日2009-12-08
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing
J.Biol.Chem., 285, 2010
3GYP
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RTT106P
分子名称:Histone chaperone RTT106, BETA-MERCAPTOETHANOL, CHLORIDE ION
著者Liu, Y., Huang, H., Shi, Y., Teng, M.
登録日2009-04-04
公開日2009-12-08
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.406 Å)
主引用文献Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing
J.Biol.Chem., 285, 2010
3S5J
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2.0A CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE 1
分子名称:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
著者Chen, P., Teng, M., Li, X.
登録日2011-05-23
公開日2012-05-23
最終更新日2015-04-22
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
3ZC6
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CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH AN INDAZOLE SUBSTITUTED PYRROLOPYRAZINE INHIBITOR
分子名称:TYROSINE-PROTEIN KINASE JAK3, N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, DI(HYDROXYETHYL)ETHER, ...
著者Kuglstatter, A., Jestel, A., Nagel, S., Boettcher, J., Blaesse, M.
登録日2012-11-16
公開日2013-09-25
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Strategic Use of Conformational Bias and Structure Based Design to Identify Potent Jak3 Inhibitors with Improved Selectivity Against the Jak Family and the Kinome.
Bioorg.Med.Chem.Lett., 23, 2013