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4XP1
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BU of 4xp1 by Molmil
X-ray structure of Drosophila dopamine transporter bound to neurotransmitter dopamine
Descriptor: 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gouaux, E, Penmatsa, A, Wang, K.
Deposit date:2015-01-16
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
4XP5
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BU of 4xp5 by Molmil
X-ray structure of Drosophila dopamine transporter bound to cocaine analogue-RTI55
Descriptor: 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, Antibody fragment heavy chain-protein, 9D5-heavy chain, ...
Authors:Gouaux, E, Penmatsa, A, Wang, K.
Deposit date:2015-01-16
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
1FTM
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BU of 1ftm by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION
Descriptor: (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, GLUTAMATE RECEPTOR SUBUNIT 2, ZINC ION
Authors:Gouaux, E, Armstrong, N.
Deposit date:2000-09-12
Release date:2000-11-01
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
1FTK
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BU of 1ftk by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2I) IN COMPLEX WITH KAINATE AT 1.6 A RESOLUTION
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR SUBUNIT 2
Authors:Gouaux, E, Armstrong, N.
Deposit date:2000-09-12
Release date:2000-11-01
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
6NJM
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BU of 6njm by Molmil
Architecture and subunit arrangement of native AMPA receptors
Descriptor: 15F1 Fab heavy chain, 15F1 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gouaux, E, Zhao, Y.
Deposit date:2019-01-03
Release date:2019-04-24
Last modified:2021-05-05
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM.
Science, 364, 2019
6NJL
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BU of 6njl by Molmil
Architecture and subunit arrangement of native AMPA receptors
Descriptor: 11B8 scFv, 15F1 Fab heavy chain, 15F1 Fab light chain, ...
Authors:Gouaux, E, Zhao, Y.
Deposit date:2019-01-03
Release date:2019-04-24
Last modified:2021-05-05
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM.
Science, 364, 2019
6NJN
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BU of 6njn by Molmil
Architecture and subunit arrangement of native AMPA receptors
Descriptor: 11B8 scFv, 15F1 Fab heavy chain, 15F1 Fab light chain, ...
Authors:Gouaux, E, Zhao, Y.
Deposit date:2019-01-03
Release date:2019-04-24
Last modified:2021-05-05
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM.
Science, 364, 2019
2NWX
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BU of 2nwx by Molmil
Crystal structure of GltPh in complex with L-aspartate and sodium ions
Descriptor: 425aa long hypothetical proton glutamate symport protein, ASPARTIC ACID, PALMITIC ACID, ...
Authors:Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K.
Deposit date:2006-11-16
Release date:2007-02-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature, 445, 2007
2NWL
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BU of 2nwl by Molmil
Crystal structure of GltPh in complex with L-Asp
Descriptor: ASPARTIC ACID, PALMITIC ACID, glutamate symport protein
Authors:Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K.
Deposit date:2006-11-15
Release date:2007-02-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature, 445, 2007
2NWW
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BU of 2nww by Molmil
Crystal structure of GltPh in complex with TBOA
Descriptor: (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID, 425aa long hypothetical proton glutamate symport protein
Authors:Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K.
Deposit date:2006-11-16
Release date:2007-02-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature, 445, 2007
6C13
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BU of 6c13 by Molmil
CryoEM structure of mouse PCDH15-4EC-LHFPL5 complex
Descriptor: Protocadherin-15, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Gouaux, E, Ge, J, Elferich, J.
Deposit date:2018-01-03
Release date:2018-08-15
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (11.33 Å)
Cite:Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Elife, 7, 2018
6C10
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BU of 6c10 by Molmil
Crystal structure of mouse PCDH15 EC11-EL
Descriptor: Protocadherin-15, alpha-D-mannopyranose
Authors:Gouaux, E, Elferich, J, Ge, J.
Deposit date:2018-01-03
Release date:2018-08-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Elife, 7, 2018
6C14
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BU of 6c14 by Molmil
CryoEM structure of mouse PCDH15-1EC-LHFPL5 complex
Descriptor: LHFPL tetraspan subfamily member 5 protein, Protocadherin-15
Authors:Gouaux, E, Elferich, J, Ge, J.
Deposit date:2018-01-03
Release date:2018-08-15
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Elife, 7, 2018
4TLM
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BU of 4tlm by Molmil
Crystal structure of GluN1/GluN2B NMDA receptor, structure 2
Descriptor: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ...
Authors:Gouaux, E, Lee, C.-H, Lu, W.
Deposit date:2014-05-30
Release date:2014-07-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.77 Å)
Cite:NMDA receptor structures reveal subunit arrangement and pore architecture.
Nature, 511, 2014
4TLL
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BU of 4tll by Molmil
Crystal structure of GluN1/GluN2B NMDA receptor, structure 1
Descriptor: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ...
Authors:Gouaux, E, Lee, C.-H, Lu, W.
Deposit date:2014-05-30
Release date:2014-07-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.59 Å)
Cite:NMDA receptor structures reveal subunit arrangement and pore architecture.
Nature, 511, 2014
4M48
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BU of 4m48 by Molmil
X-ray structure of dopamine transporter elucidates antidepressant mechanism
Descriptor: 9D5 antibody, heavy chain, light chain, ...
Authors:Gouaux, E, Penmatsa, A, Wang, K.
Deposit date:2013-08-06
Release date:2013-09-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.955 Å)
Cite:X-ray structure of dopamine transporter elucidates antidepressant mechanism.
Nature, 503, 2013
8VBY
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BU of 8vby by Molmil
Structure of the human dopamine transporter in complex with beta-CFT, MRS7292 and divalent zinc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, DECANE, ...
Authors:Srivastava, D.K, Gouaux, E.
Deposit date:2023-12-12
Release date:2024-08-07
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:Structure of the human dopamine transporter and mechanisms of inhibition.
Nature, 632, 2024
2AL5
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BU of 2al5 by Molmil
Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with fluoro-willardiine and aniracetam
Descriptor: 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2
Authors:Jin, R, Clark, S, Weeks, A.M, Dudman, J.T, Gouaux, E, Partin, K.M.
Deposit date:2005-08-04
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Mechanism of positive allosteric modulators acting on AMPA receptors.
J.Neurosci., 25, 2005
3KG2
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BU of 3kg2 by Molmil
AMPA subtype ionotropic glutamate receptor in complex with competitive antagonist ZK 200775
Descriptor: Glutamate receptor 2, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Sobolevsky, A.I, Rosconi, M.P, Gouaux, E.
Deposit date:2009-10-28
Release date:2009-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.
Nature, 462, 2009
3KGC
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BU of 3kgc by Molmil
Isolated ligand binding domain dimer of GluA2 ionotropic glutamate receptor in complex with glutamate, LY 404187 and ZK 200775
Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N-[(2S)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide, ...
Authors:Sobolevsky, A.I, Rosconi, M.P, Gouaux, E.
Deposit date:2009-10-28
Release date:2009-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
Nature, 462, 2009
3RIA
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BU of 3ria by Molmil
C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and iodide.
Descriptor: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, CHLORIDE ION, ...
Authors:Hibbs, R.E, Gouaux, E.
Deposit date:2011-04-13
Release date:2011-05-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Principles of activation and permeation in an anion-selective Cys-loop receptor.
Nature, 474, 2011
3RI5
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BU of 3ri5 by Molmil
C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin
Descriptor: (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Hibbs, R.E, Gouaux, E.
Deposit date:2011-04-12
Release date:2011-05-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Principles of activation and permeation in an anion-selective Cys-loop receptor.
Nature, 474, 2011
6VTL
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BU of 6vtl by Molmil
Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a resting state at high pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1
Authors:Yoder, N, Gouaux, E.
Deposit date:2020-02-12
Release date:2020-03-11
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity.
Elife, 9, 2020
8TKP
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BU of 8tkp by Molmil
Structure of the C. elegans TMC-2 complex
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Clark, S, Jeong, H, Goehring, A, Posert, R, Gouaux, E.
Deposit date:2023-07-25
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
Proc.Natl.Acad.Sci.USA, 121, 2024
8FOI
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BU of 8foi by Molmil
Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA and allopregnanolone
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, DODECANE, ...
Authors:Sun, C, Gouaux, E.
Deposit date:2022-12-30
Release date:2023-09-20
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
Nature, 622, 2023

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