Author results

4TVR
  • Download 4tvr
  • View 4tvr
Molmil generated image of 4tvr
TANDEM TUDOR AND PHD DOMAINS OF UHRF2
Descriptor:E3 ubiquitin-protein ligase UHRF2, ZINC ION, UNKNOWN ATOM OR ION
Authors:Walker, J.R., Dong, A., Zhang, Q., Ong, M., Duan, S., Li, Y., Bountra, C., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2015-06-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure of the Tandem Tudor and PHD domains of UHRF2
To be published
4X3G
  • Download 4x3g
  • View 4x3g
Molmil generated image of 4x3g
CRYSTAL STRUCTURE OF SIAH1 SINA DOMAIN IN COMPLEX WITH A USP19 PEPTIDE
Descriptor:E3 ubiquitin-protein ligase SIAH1, Ubiquitin carboxyl-terminal hydrolase 19, ZINC ION
Authors:Walker, J.R., Dong, A., Zhang, Q., Huang, X., Li, Y., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2014-11-28
Release date:2014-12-31
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystal structure of SIAH1 SINA domain in complex with a USP19 peptide
To be published
4YWQ
  • Download 4ywq
  • View 4ywq
Molmil generated image of 4ywq
CRYSTAL STRUCTURE OF THE ROQ DOMAIN OF HUMAN ROQUIN-1
Descriptor:Roquin-1, ZINC ION, GLYCEROL, ...
Authors:Dong, A., Zhang, Q., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-03-20
Release date:2015-04-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the ROQ domain of human Roquin-1
To be Published
5C7J
  • Download 5c7j
  • View 5c7j
Molmil generated image of 5c7j
CRYSTAL STRUCTURE OF NEDD4 WITH A UB VARIANT
Descriptor:E3 ubiquitin-protein ligase NEDD4, Polyubiquitin-C
Authors:Walker, J.R., Hu, J., Dong, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-06-24
Release date:2016-03-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5C7M
  • Download 5c7m
  • View 5c7m
Molmil generated image of 5c7m
CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT
Descriptor:E3 ubiquitin-protein ligase Itchy homolog, Polyubiquitin-C
Authors:Walker, J.R., Hu, J., Dong, A., Wernimont, A., Zhang, W., Sidhu, S., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-06-24
Release date:2016-03-16
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5TF2
  • Download 5tf2
  • View 5tf2
Molmil generated image of 5tf2
CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN
Descriptor:Prolactin regulatory element-binding protein, UNKNOWN ATOM OR ION
Authors:Walker, J.R., Zhang, Q., Dong, A., Wernimont, A., Li, Y., He, H., Tempel, W., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Chen, Z., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2016-09-23
Release date:2016-11-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN (CASP target)
To be published
5WCH
  • Download 5wch
  • View 5wch
Molmil generated image of 5wch
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN USP9X
Descriptor:Probable ubiquitin carboxyl-terminal hydrolase FAF-X, ZINC ION, UNKNOWN ATOM OR ION
Authors:Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6BY9
  • Download 6by9
  • View 6by9
Molmil generated image of 6by9
CRYSTAL STRUCTURE OF EHMT1
Descriptor:Histone-lysine N-methyltransferase EHMT1, UNKNOWN ATOM OR ION
Authors:Dong, A., Wei, Y., Li, A., Tempel, W., Han, S., Sunnerhagen, M., Penn, L., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-12-20
Release date:2018-01-31
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of EHMT1
to be published
6CVZ
  • Download 6cvz
  • View 6cvz
Molmil generated image of 6cvz
CRYSTAL STRUCTURE OF THE WD40-REPEAT OF RFWD3
Descriptor:E3 ubiquitin-protein ligase RFWD3, MAGNESIUM ION
Authors:DONG, A., LOPPNAU, P., SEITOVA, A., HUTCHINSON, A., TEMPEL, W., WEI, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2018-03-29
Release date:2018-06-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the WD40-repeat of RFWD3
to be published
1Y9X
  • Download 1y9x
  • View 1y9x
Molmil generated image of 1y9x
SOLUTION STRUCTURE OF ARCHAEON DNA-BINDING PROTEIN SSH10B
Descriptor:DNA/RNA-binding protein Alba 1
Authors:Cui, Q., Tong, Y., Wang, J.
Deposit date:2004-12-16
Release date:2005-06-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A stabilizing alpha/beta-hydrophobic core greatly contributes to hyperthermostability of archaeal [P62A]Ssh10b.
Biochemistry, 47, 2008
1K9O
  • Download 1k9o
  • View 1k9o
Molmil generated image of 1k9o
CRYSTAL STRUCTURE OF MICHAELIS SERPIN-TRYPSIN COMPLEX
Descriptor:ALASERPIN, TRYPSIN II ANIONIC
Authors:Ye, S., Cech, A.L., Belmares, R., Bergstrom, R.C., Tong, Y., Corey, D.R., Kanost, M.R., Goldsmith, E.J.
Deposit date:2001-10-29
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of a Michaelis serpin-protease complex.
Nat.Struct.Biol., 8, 2001
2PQE
  • Download 2pqe
  • View 2pqe
Molmil generated image of 2pqe
SOLUTION STRUCTURE OF PROLINE-FREE MUTANT OF STAPHYLOCOCCAL NUCLEASE
Descriptor:Thermonuclease
Authors:Shan, L., Tong, Y., Xie, T., Wang, M., Wang, J.
Deposit date:2007-05-01
Release date:2007-06-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Restricted backbone conformational and motional flexibilities of loops containing peptidyl-proline bonds dominate the enzyme activity of staphylococcal nuclease.
Biochemistry, 46, 2007
3C5C
  • Download 3c5c
  • View 3c5c
Molmil generated image of 3c5c
CRYSTAL STRUCTURE OF HUMAN RAS-LIKE, FAMILY 12 PROTEIN IN COMPLEX WITH GDP
Descriptor:RAS-like protein 12, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Shen, L., Tong, Y., Tempel, W., Loppnau, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-01-31
Release date:2008-02-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of human Ras-like, family 12 protein in complex with GDP.
To be Published
3C5H
  • Download 3c5h
  • View 3c5h
Molmil generated image of 3c5h
CRYSTAL STRUCTURE OF THE RAS HOMOLOG DOMAIN OF HUMAN GRLF1 (P190RHOGAP)
Descriptor:Glucocorticoid receptor DNA-binding factor 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-01-31
Release date:2008-02-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP).
To be Published
3CON
  • Download 3con
  • View 3con
Molmil generated image of 3con
CRYSTAL STRUCTURE OF THE HUMAN NRAS GTPASE BOUND WITH GDP
Descriptor:GTPase NRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Nedyalkova, L., Tong, Y., Tempel, W., Shen, L., Loppnau, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-03-28
Release date:2008-04-08
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.649 Å)
Cite:Crystal structure of the human NRAS GTPase bound with GDP.
To be Published
3CXL
  • Download 3cxl
  • View 3cxl
Molmil generated image of 3cxl
CRYSTAL STRUCTURE OF HUMAN CHIMERIN 1 (CHN1)
Descriptor:N-chimerin, ZINC ION, UNKNOWN ATOM OR ION
Authors:Shen, L., Buck, M., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Wilkstrom, M., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-04-24
Release date:2008-08-05
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of human chimerin 1 (CHN1).
To be Published
3DWD
  • Download 3dwd
  • View 3dwd
Molmil generated image of 3dwd
CRYSTAL STRUCTURE OF THE ARFGAP DOMAIN OF HUMAN ARFGAP1
Descriptor:ADP-ribosylation factor GTPase-activating protein 1, ZINC ION, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L., Tong, Y., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Wilkstrom, M., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-07-22
Release date:2008-08-05
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the ArfGAP domain of human ARFGAP1
To be Published
3EO2
  • Download 3eo2
  • View 3eo2
Molmil generated image of 3eo2
CRYSTAL STRUCTURE OF THE RHOGEF DOMAIN OF HUMAN NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEIN
Descriptor:Neuroepithelial cell-transforming gene 1 protein, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-09-26
Release date:2008-10-07
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein
To be Published
3FK2
  • Download 3fk2
  • View 3fk2
Molmil generated image of 3fk2
CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF HUMAN GLUCOCORTICOID RECEPTOR DNA-BINDING FACTOR 1
Descriptor:Glucocorticoid receptor DNA-binding factor 1, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L., Tong, Y., Tempel, W., Loppnau, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-12-15
Release date:2008-12-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the RhoGAP domain of human glucocorticoid receptor DNA-binding factor 1
To be Published
3GRO
  • Download 3gro
  • View 3gro
Molmil generated image of 3gro
HUMAN PALMITOYL-PROTEIN THIOESTERASE 1
Descriptor:Palmitoyl-protein thioesterase 1, UNKNOWN ATOM OR ION
Authors:Dobrovetsky, E., Seitova, A., Tong, Y., Tempel, W., Dong, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Cossar, D., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-03-26
Release date:2009-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Human palmitoyl-protein thioesterase 1
To be Published
3HM5
  • Download 3hm5
  • View 3hm5
Molmil generated image of 3hm5
SANT DOMAIN OF HUMAN DNA METHYLTRANSFERASE 1 ASSOCIATED PROTEIN 1
Descriptor:DNA methyltransferase 1-associated protein 1, CALCIUM ION, UNKNOWN ATOM OR ION
Authors:Dombrovski, L., Tempel, W., Amaya, M.F., Tong, Y., Ni, S., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Park, H., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2009-05-28
Release date:2009-06-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:SANT domain of human DNA methyltransferase 1 associated protein 1
To be Published
3HM8
  • Download 3hm8
  • View 3hm8
Molmil generated image of 3hm8
CRYSTAL STRUCTURE OF THE C-TERMINAL HEXOKINASE DOMAIN OF HUMAN HK3
Descriptor:Hexokinase-3, ALPHA-D-GLUCOSE, BETA-D-GLUCOSE-6-PHOSPHATE
Authors:Nedyalkova, L., Tong, Y., Rabeh, W., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-05-28
Release date:2009-08-11
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the C-terminal Hexokinase domain of human HK3
To be Published
3HZJ
  • Download 3hzj
  • View 3hzj
Molmil generated image of 3hzj
CRYSTAL STRUCTURE OF THE RABGAP DOMAIN OF THE RABGAP1L PROTEIN
Descriptor:RAB GTPase-activating protein 1-like, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L., Tempel, W., Tong, Y., Zhong, N., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-06-23
Release date:2009-07-14
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the RabGAP domain of the RABGAP1L protein
To be Published
3IEZ
  • Download 3iez
  • View 3iez
Molmil generated image of 3iez
CRYSTAL STRUCTURE OF THE RASGAP C-TERMINAL (RGC) DOMAIN OF IQGAP2
Descriptor:Ras GTPase-activating-like protein IQGAP2, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L., Tempel, W., Tong, Y., Zhong, N., Crombet, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-07-23
Release date:2009-11-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the RasGAP C-terminal (RGC) domain of IQGAP2
To be Published
3ISU
  • Download 3isu
  • View 3isu
Molmil generated image of 3isu
CRYSTAL STRUCTURE OF THE RGC DOMAIN OF IQGAP3
Descriptor:Ras GTPase-activating-like protein IQGAP3
Authors:Nedyalkova, L., Tempel, W., Tong, Y., Crombet, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-08-27
Release date:2009-09-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structure of the RGC domain of IQGAP3
to be published