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8DYP
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BU of 8dyp by Molmil
Crystal structure of human cystine transporter cystinosin
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Cystinosin, Nanobody P10, ...
Authors:Guo, X, Feng, L.
Deposit date:2022-08-04
Release date:2022-11-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure and mechanism of human cystine exporter cystinosin.
Cell, 185, 2022
6FLP
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BU of 6flp by Molmil
CryoEM structure of E.coli RNA polymerase paused elongation complex without RNA hairpin bound to NusA
Descriptor: DNA (30-MER), DNA (39-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Guo, X, Weixlbaumer, A.
Deposit date:2018-01-26
Release date:2018-03-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural Basis for NusA Stabilized Transcriptional Pausing.
Mol. Cell, 69, 2018
6FLQ
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BU of 6flq by Molmil
CryoEM structure of E.coli RNA polymerase paused elongation complex bound to NusA
Descriptor: DNA (31-MER), DNA (39-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Guo, X, Weixlbaumer, A.
Deposit date:2018-01-26
Release date:2018-03-21
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis for NusA Stabilized Transcriptional Pausing.
Mol. Cell, 69, 2018
6ZM9
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BU of 6zm9 by Molmil
PHAGE SAM LYASE IN COMPLEX WITH S-METHYL-5'-THIOADENOSINE
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Chains: A, PHOSPHATE ION, ...
Authors:Guo, X, Kanchugal P, S, Selmer, M.
Deposit date:2020-07-02
Release date:2021-02-24
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family.
Elife, 10, 2021
6ZMG
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BU of 6zmg by Molmil
PHAGE SAM LYASE IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE
Descriptor: Chains: A, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Guo, X, Kanchugal P, S, Selmer, M.
Deposit date:2020-07-02
Release date:2021-02-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family.
Elife, 10, 2021
7YLQ
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BU of 7ylq by Molmil
Crystal structure of Microcystinase C from Sphingomonas sp. ACM-3962 at 2.6 A resolution
Descriptor: CALCIUM ION, Microcystinase C, ZINC ION
Authors:Guo, X, Li, Z, Ding, W, Yin, P, Feng, L.
Deposit date:2022-07-26
Release date:2023-08-09
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal structure of Microcystin C from Sphingomonas sp. ACM-3962 at 2.6 A resolution
To Be Published
4U7T
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BU of 4u7t by Molmil
Crystal structure of DNMT3A-DNMT3L in complex with histone H3
Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Guo, X, Wang, L, Yin, X, Li, J, Xiao, J, He, S, Wang, J, Xu, Y.
Deposit date:2014-07-31
Release date:2014-11-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
Nature, 517, 2015
4ADO
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BU of 4ado by Molmil
Fusidic acid resistance protein FusB
Descriptor: FAR1, ZINC ION
Authors:Guo, X, Peisker, K, Backbro, K, Chen, Y, Kiran, R.K, Sanyal, S, Selmer, M.
Deposit date:2011-12-31
Release date:2012-03-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and Function of Fusb: An Elongation Factor G-Binding Fusidic Acid Resistance Protein Active in Ribosomal Translocation and Recycling
Open Biol., 2, 2012
4ADN
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BU of 4adn by Molmil
Fusidic acid resistance protein FusB
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, FAR1, ...
Authors:Guo, X, Peisker, K, Backbro, K, Chen, Y, Kiran, R.K, Sanyal, S, Selmer, M.
Deposit date:2011-12-31
Release date:2012-03-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and Function of Fusb: An Elongation Factor G-Binding Fusidic Acid Resistance Protein Active in Ribosomal Translocation and Recycling
Open Biol., 2, 2012
8KCP
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BU of 8kcp by Molmil
Cryo-EM structure of human gamma-secretase in complex with Crenigacestat
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2023-08-08
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs
To Be Published
8KCO
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BU of 8kco by Molmil
Cryo-EM structure of human gamma-secretase in complex with RO4929097
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2023-08-08
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560
To Be Published
8KCU
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BU of 8kcu by Molmil
Cryo-EM structure of human gamma-secretase in complex with MK-0752
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2023-08-08
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs
To Be Published
8KCT
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BU of 8kct by Molmil
Cryo-EM structure of human gamma-secretase in complex with Nirogacestat
Descriptor: (2S)-2-[[(2S)-6,8-bis(fluoranyl)-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methyl-propan-2-yl]imidazol-4-yl]pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2023-08-08
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs
To Be Published
8KCS
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BU of 8kcs by Molmil
Cryo-EM structure of human gamma-secretase in complex with BMS906024
Descriptor: (2S,3R)-N'-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2,3-bis[3,3,3-tris(fluoranyl)propyl]butanediamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2023-08-08
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs
To Be Published
8X54
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BU of 8x54 by Molmil
Cryo-EM structure of human gamma-secretase in complex with APP-C99
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2023-11-16
Release date:2024-05-29
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular mechanism of substrate recognition and cleavage by human gamma-secretase.
Science, 384, 2024
8X52
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BU of 8x52 by Molmil
Cryo-EM structure of human gamma-secretase in complex with Abeta49
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2023-11-16
Release date:2024-05-29
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular mechanism of substrate recognition and cleavage by human gamma-secretase.
Science, 384, 2024
8X53
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BU of 8x53 by Molmil
Cryo-EM structure of human gamma-secretase in complex with Abeta46
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2023-11-16
Release date:2024-05-29
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular mechanism of substrate recognition and cleavage by human gamma-secretase.
Science, 384, 2024
7Y5X
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BU of 7y5x by Molmil
CryoEM structure of PS2-containing gamma-secretase treated with MRK-560
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2022-06-17
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Nat Commun, 13, 2022
7Y5T
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BU of 7y5t by Molmil
CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2022-06-17
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Nat Commun, 13, 2022
7Y5Z
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BU of 7y5z by Molmil
CryoEM structure of human PS2-containing gamma-secretase
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2022-06-18
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Nat Commun, 13, 2022
6IQD
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BU of 6iqd by Molmil
Crystal structure of Alcohol dehydrogenase from Geobacillus stearothermophilus
Descriptor: Alcohol dehydrogenase, ZINC ION
Authors:Xue, S, Feng, Y, Guo, X, Zhao, Z.
Deposit date:2018-11-07
Release date:2019-06-05
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Characterization of the substrate scope of an alcohol dehydrogenase commonly used as methanol dehydrogenase.
Bioorg.Med.Chem.Lett., 29, 2019
5L6U
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BU of 5l6u by Molmil
S. ENTERICA HISA MUTANT - D10G, DUP13-15, Q24L, G102A
Descriptor: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, SULFATE ION
Authors:Guo, X, Soderholm, A, Selmer, M.
Deposit date:2016-05-31
Release date:2017-04-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5L9F
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BU of 5l9f by Molmil
S. enterica HisA mutant - D10G, G11D, dup13-15, G44E, G102A
Descriptor: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, SODIUM ION, SULFATE ION
Authors:Guo, X, Soderholm, A, Selmer, M.
Deposit date:2016-06-10
Release date:2017-04-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.594 Å)
Cite:Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4U7P
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BU of 4u7p by Molmil
Crystal structure of DNMT3A-DNMT3L complex
Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Wang, L, Guo, X, Li, J, Xiao, J, Yin, X, He, S, Wang, J, Xu, Y.
Deposit date:2014-07-31
Release date:2014-11-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.821 Å)
Cite:Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
Nature, 517, 2015
5ABT
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BU of 5abt by Molmil
S.enterica HisA mutant D7N, G102A, V106M, D176A
Descriptor: 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO) METHYLIDENE AMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE, [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate
Authors:Guo, X, Soderholm, A, Newton, M, Nasvall, J, Andersson, D, Patrick, W, Selmer, M.
Deposit date:2015-08-08
Release date:2016-09-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Protein Structures, Functions and Dynamics of Adaptive Evolution
To be Published

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