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4CX2
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(5-(((3R,4R)-4-((6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL) PYRROLIDIN-3-YL)OXY)PENTYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-04-03
Release date:2014-08-13
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.
Biochemistry, 53, 2014
4CX3
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE M336V D597N MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL) PENTYL)OXY)PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-04-03
Release date:2014-08-13
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.
Biochemistry, 53, 2014
4CX4
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE M336V D597N MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(((3R,4R)-4-((5-(4- METHYLPYRIDIN-2-YL)PENTYL)OXY)PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-04-03
Release date:2014-08-13
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.
Biochemistry, 53, 2014
4CX5
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE H341L MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL) PENTYL)OXY)PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-04-03
Release date:2014-08-13
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.
Biochemistry, 53, 2014
4CX6
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE H341L MUTANT HEME DOMAIN IN COMPLEX WITH 6-((((3S, 5R)-5-(((6-AMINO-4-METHYLPYRIDIN-2- YL)METHOXY)METHYL)PYRROLIDIN-3-YL)OXY)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-04-03
Release date:2014-08-13
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.
Biochemistry, 53, 2014
4CX7
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STRUCTURE OF HUMAN INOS HEME DOMAIN IN COMPLEX WITH (R)-6-(3-AMINO-2-(5-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)PROPYL)-4- METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, INDUCIBLE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-04-03
Release date:2014-08-13
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.
Biochemistry, 53, 2014
4FLA
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CRYSTAL STRUCTURE OF HUMAN RPRD1B, CARBOXY-TERMINAL DOMAIN
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 1B, UNKNOWN ATOM OR ION
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2012-06-14
Release date:2012-08-22
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
4FLB
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CID OF HUMAN RPRD2
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 2, SULFATE ION, PRASEODYMIUM ION, ...
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2012-06-14
Release date:2012-08-15
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
4JXT
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CID OF HUMAN RPRD1A IN COMPLEX WITH A PHOSPHORYLATED PEPTIDE FROM RPB1-CTD
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 1A, DNA-directed RNA polymerase II subunit RPB1, UNKNOWN ATOM OR ION
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2013-03-28
Release date:2013-11-13
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
4Q94
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HUMAN RPRD1B CID IN COMPLEX WITH A RPB1-CTD DERIVED SER2 PHOSPHORYLATED PEPTIDE
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 1B, rpb1-ctd, SULFATE ION, ...
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2014-04-29
Release date:2014-06-18
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
4Q96
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CID OF HUMAN RPRD1B IN COMPLEX WITH AN UNMODIFIED CTD PEPTIDE
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 1B, RPB1-CTD, UNKNOWN ATOM OR ION, ...
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2014-04-29
Release date:2014-06-04
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
5J39
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CRYSTAL STRUCTURE OF THE EXTENDED TUDOR DOMAIN FROM TDRD2
Descriptor:Tudor and KH domain-containing protein, CACODYLATE ION, UNKNOWN ATOM OR ION
Authors:Zhang, H., Tempel, W., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2016-03-30
Release date:2016-04-13
Last modified:2018-08-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6B57
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TUDOR IN COMPLEX WITH LIGAND
Descriptor:Tudor and KH domain-containing protein, UNKNOWN ATOM OR ION
Authors:Zhang, H., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-09-28
Release date:2017-11-01
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3L8E
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CRYSTAL STRUCTURE OF APO FORM OF D,D-HEPTOSE 1.7-BISPHOSPHATE PHOSPHATASE FROM E. COLI
Descriptor:D,D-heptose 1,7-bisphosphate phosphatase, ZINC ION, ACETIC ACID
Authors:Nguyen, H., Peisach, E., Allen, K.N.
Deposit date:2009-12-31
Release date:2010-02-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structural Determinants of Substrate Recognition in the HAD Superfamily Member d-glycero-d-manno-Heptose-1,7-bisphosphate Phosphatase (GmhB) .
Biochemistry, 49, 2010
3L8F
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CRYSTAL STRUCTURE OF D,D-HEPTOSE 1.7-BISPHOSPHATE PHOSPHATASE FROM E. COLI COMPLEXED WITH MAGNESIUM AND PHOSPHATE
Descriptor:D,D-heptose 1,7-bisphosphate phosphatase, MAGNESIUM ION, ZINC ION, ...
Authors:Nguyen, H., Peisach, E., Allen, K.N.
Deposit date:2009-12-31
Release date:2010-02-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural Determinants of Substrate Recognition in the HAD Superfamily Member d-glycero-d-manno-Heptose-1,7-bisphosphate Phosphatase (GmhB) .
Biochemistry, 49, 2010
3L8G
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CRYSTAL STRUCTURE OF D,D-HEPTOSE 1.7-BISPHOSPHATE PHOSPHATASE FROM E. COLI COMPLEXED WITH D-GLYCERO-D-MANNO-HEPTOSE 1 ,7-BISPHOSPHATE
Descriptor:D,D-heptose 1,7-bisphosphate phosphatase, MAGNESIUM ION, ZINC ION, ...
Authors:Nguyen, H., Peisach, E., Allen, K.N.
Deposit date:2009-12-31
Release date:2010-02-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural Determinants of Substrate Recognition in the HAD Superfamily Member d-glycero-d-manno-Heptose-1,7-bisphosphate Phosphatase (GmhB) .
Biochemistry, 49, 2010
3L8H
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CRYSTAL STRUCTURE OF D,D-HEPTOSE 1.7-BISPHOSPHATE PHOSPHATASE FROM B. BRONCHISEPTICA COMPLEXED WITH MAGNESIUM AND PHOSPHATE
Descriptor:Putative haloacid dehalogenase-like hydrolase, MAGNESIUM ION, ZINC ION, ...
Authors:Nguyen, H., Peisach, E., Allen, K.N.
Deposit date:2009-12-31
Release date:2010-02-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural Determinants of Substrate Recognition in the HAD Superfamily Member d-glycero-d-manno-Heptose-1,7-bisphosphate Phosphatase (GmhB) .
Biochemistry, 49, 2010
4D3I
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6,6'-((5-(AMINOMETHYL)-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4- METHYLPYRIDIN-2-AMINE)
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-{[5-(aminomethyl)benzene-1,3-diyl]diethane-2,1-diyl}bis(4-methylpyridin-2-amine), ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-22
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3J
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4- METHYLPYRIDIN-2-AMINE)
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-22
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3K
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6,6'-((5-(3-AMINOPROPYL)-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4- METHYLPYRIDIN-2-AMINE)
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-22
Release date:2015-01-14
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.017 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3M
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)-5-(2-(4-METHYL-6-(METHYLAMINO)PYRIDIN-2-YL)ETHYL)BENZONITRILE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.741 Å)
Cite:Structure-based design of bacterial nitric oxide synthase inhibitors.
J. Med. Chem., 58, 2015
4D3N
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)-5-((2-(PYRIDIN-2-YL)ETHYL)AMINO)BENZONITRILE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 3-[2-(6-amino-4-methylpyridin-2-yl)ethyl]-5-{[2-(pyridin-2-yl)ethyl]amino}benzonitrile, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structure-based design of bacterial nitric oxide synthase inhibitors.
J. Med. Chem., 58, 2015
4D3O
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6-(3-(2-(1H-PYRROLO(2,3-B)PYRIDIN-6-YL)ETHYL)-5-(AMINOMETHYL) PHENETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3T
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH N-{3-[(1S)-2-(3-{(Z)-[AMINO(THIOPHEN-2-YL)METHYLIDENE]AMINO}PHENOXY)-1-HYDROXYETHYL]PHENYL}THIOPHENE-2-CARBOXIMIDAMIDE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3U
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE H128S IN COMPLEX WITH N-{3-[(1S)-2-(3-{(Z)-[AMINO(THIOPHEN-2-YL)METHYLIDENE]AMINO}PHENOXY)-1-HYDROXYETHYL]PHENYL}THIOPHENE-2-CARBOXIMIDAMIDE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.981 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015