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1BGW
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BU of 1bgw by Molmil
TOPOISOMERASE RESIDUES 410-1202,
Descriptor: TOPOISOMERASE
Authors:Berger, J.M, Gamblin, S.J, Harrison, S.C, Wang, J.C.
Deposit date:1996-02-20
Release date:1996-07-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and mechanism of DNA topoisomerase II.
Nature, 379, 1996
6DUQ
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BU of 6duq by Molmil
Structure of a Rho-NusG KOW domain complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
Authors:Berger, J.M, Lawson, M.R.
Deposit date:2018-06-21
Release date:2018-09-05
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein.
Mol. Cell, 71, 2018
3KDE
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BU of 3kde by Molmil
Crystal structure of the THAP domain from D. melanogaster P-element transposase in complex with its natural DNA binding site
Descriptor: 5'-D(*(BRU)P*CP*CP*AP*CP*TP*TP*AP*AP*C)-3', 5'-D(*GP*TP*TP*AP*AP*GP*(BRU)P*GP*GP*A)-3', Transposable element P transposase, ...
Authors:Sabogal, A, Lyubimov, A.Y, Berger, J.M, Rio, D.C.
Deposit date:2009-10-22
Release date:2009-12-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves.
Nat.Struct.Mol.Biol., 17, 2010
2A8V
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BU of 2a8v by Molmil
RHO TRANSCRIPTION TERMINATION FACTOR/RNA COMPLEX
Descriptor: 5'-R(P*CP*CP*C)-3', 5'-R(P*CP*CP*CP*CP*CP*C)-3', RNA BINDING DOMAIN OF RHO TRANSCRIPTION TERMINATION FACTOR
Authors:Bogden, C.E, Fass, D, Bergman, N, Nichols, M.D, Berger, J.M.
Deposit date:1998-11-08
Release date:1999-04-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structural basis for terminator recognition by the Rho transcription termination factor.
Mol.Cell, 3, 1999
2A11
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BU of 2a11 by Molmil
Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis
Descriptor: CALCIUM ION, Ribonuclease III
Authors:Akey, D.L, Berger, J.M, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2005-06-17
Release date:2005-07-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A
Protein Sci., 14, 2005
1QZR
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BU of 1qzr by Molmil
CRYSTAL STRUCTURE OF THE ATPASE REGION OF SACCHAROMYCES CEREVISIAE TOPOISOMERASE II BOUND TO ICRF-187 (DEXRAZOXANE)
Descriptor: (S)-4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-2,6-PIPERAZINEDIONE, DNA topoisomerase II, MAGNESIUM ION, ...
Authors:Classen, S, Olland, S, Berger, J.M.
Deposit date:2003-09-17
Release date:2003-09-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187
Proc.Natl.Acad.Sci.USA, 100, 2003
3KML
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BU of 3kml by Molmil
Circular Permutant of the Tobacco Mosaic Virus
Descriptor: Coat protein
Authors:Duderstadt, K.E, Dedeo, M.T, Francis, M.B, Berger, J.M.
Deposit date:2009-11-10
Release date:2010-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.011 Å)
Cite:Nanoscale protein assemblies from a circular permutant of the tobacco mosaic virus.
Nano Lett., 10, 2010
3L4J
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BU of 3l4j by Molmil
Topoisomerase II-DNA cleavage complex, apo
Descriptor: 3'-THIO-THYMIDINE-5'-PHOSPHATE, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*CP*GP*TP*CP*AP*TP*CP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), ...
Authors:Schmidt, B.H, Burgin, A.B, Deweese, J.E, Osheroff, N, Berger, J.M.
Deposit date:2009-12-20
Release date:2010-05-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases.
Nature, 465, 2010
3L4K
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BU of 3l4k by Molmil
Topoisomerase II-DNA cleavage complex, metal-bound
Descriptor: 3'-THIO-THYMIDINE-5'-PHOSPHATE, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*CP*GP*TP*CP*AP*TP*CP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), ...
Authors:Schmidt, B.H, Burgin, A.B, Deweese, J.E, Osheroff, N, Berger, J.M.
Deposit date:2009-12-20
Release date:2010-05-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases.
Nature, 465, 2010
7UGW
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BU of 7ugw by Molmil
M. tuberculosis DNA gyrase cleavage core bound to DNA and evybactin
Descriptor: DNA (46-MER), DNA gyrase subunit A, DNA gyrase subunit B, ...
Authors:Hauk, G, Imai, Y, Lewis, K, Berger, J.M.
Deposit date:2022-03-25
Release date:2022-08-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis.
Nat.Chem.Biol., 18, 2022
8TXR
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BU of 8txr by Molmil
E. coli ExoVII(H238A)
Descriptor: Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease 7 small subunit
Authors:Liu, C, Berger, J.M.
Deposit date:2023-08-24
Release date:2024-01-31
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of Escherichia coli exonuclease VII.
Proc.Natl.Acad.Sci.USA, 121, 2024
1BJT
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BU of 1bjt by Molmil
TOPOISOMERASE II RESIDUES 409-1201
Descriptor: TOPOISOMERASE II
Authors:Fass, D, Bogden, C.E, Berger, J.M.
Deposit date:1998-06-29
Release date:1999-05-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands.
Nat.Struct.Biol., 6, 1999
4WMG
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BU of 4wmg by Molmil
Structure of hen egg-white lysozyme from a microfludic harvesting device using synchrotron radiation (2.5A)
Descriptor: Lysozyme C
Authors:Lyubimov, A.Y, Murray, T.D, Koehl, A, Uervirojnangkoorn, M, Zeldin, O.B, Cohen, A.E, Soltis, S.M, Baxter, E.M, Brewster, A.S, Sauter, N.K, Brunger, A.T, Berger, J.M.
Deposit date:2014-10-08
Release date:2015-04-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Capture and X-ray diffraction studies of protein microcrystals in a microfluidic trap array.
Acta Crystallogr.,Sect.D, 71, 2015
4XGC
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BU of 4xgc by Molmil
Crystal structure of the eukaryotic origin recognition complex
Descriptor: CHLORIDE ION, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ...
Authors:Bleichert, F, Botchan, M.R, Berger, J.M.
Deposit date:2014-12-30
Release date:2015-04-01
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of the eukaryotic origin recognition complex.
Nature, 519, 2015
3C4O
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BU of 3c4o by Molmil
Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M/S130K/S146M complex
Descriptor: Beta-lactamase SHV-1, Beta-lactamase inhibitory protein, SULFATE ION
Authors:Reynolds, K.A, Hanes, M.S, Thomson, J.M, Antczak, A.J, Berger, J.M, Bonomo, R.A, Kirsch, J.F, Handel, T.M.
Deposit date:2008-01-30
Release date:2008-05-27
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface.
J.Mol.Biol., 382, 2008
7MU5
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BU of 7mu5 by Molmil
Human DCTPP1 bound to Triptolide
Descriptor: MAGNESIUM ION, dCTP pyrophosphatase 1, triptolide
Authors:Hauk, G, Berger, J.M.
Deposit date:2021-05-14
Release date:2022-08-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance
To Be Published
4NMN
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BU of 4nmn by Molmil
Aquifex aeolicus replicative helicase (DnaB) complexed with ADP, at 3.3 resolution
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Replicative DNA helicase, ...
Authors:Lyubimov, A.Y, Strycharska, M.S, Erzberger, J.P, Berger, J.M.
Deposit date:2013-11-15
Release date:2014-01-29
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Nucleotide and partner-protein control of bacterial replicative helicase structure and function.
Mol.Cell, 52, 2013
1AOL
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BU of 1aol by Molmil
FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GP70, ZINC ION
Authors:Fass, D, Davey, R.A, Hamson, C.A, Kim, P.S, Cunningham, J.M, Berger, J.M.
Deposit date:1997-07-08
Release date:1997-10-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution.
Science, 277, 1997
2AU3
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BU of 2au3 by Molmil
Crystal Structure of the Aquifex aeolicus primase (Zinc Binding and RNA Polymerase Domains)
Descriptor: DNA primase, ZINC ION
Authors:Corn, J.E, Pease, P.J, Hura, G.L, Berger, J.M.
Deposit date:2005-08-26
Release date:2005-11-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crosstalk between primase subunits can act to regulate primer synthesis in trans.
Mol.Cell, 20, 2005
4MN4
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BU of 4mn4 by Molmil
Structural Basis for the MukB-topoisomerase IV Interaction
Descriptor: Chromosome partition protein MukB, DNA topoisomerase 4 subunit A
Authors:Vos, S.M, Stewart, N.K, Oakley, M.G, Berger, J.M.
Deposit date:2013-09-09
Release date:2013-10-23
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the MukB-topoisomerase IV interaction and its functional implications in vivo.
Embo J., 32, 2013
5HE8
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BU of 5he8 by Molmil
Bacterial initiation protein
Descriptor: Helicase loader, SULFATE ION
Authors:Hood, I.V, Berger, J.M.
Deposit date:2016-01-05
Release date:2016-06-08
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Bacterial initiation protein
To Be Published
6OK8
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BU of 6ok8 by Molmil
Crystal structure of Staphylococcal nuclease variant Delta+PHS K127L at cryogenic temperature
Descriptor: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease
Authors:Jeliazkov, J.R, Robinson, A.C, Berger, J.M, Garcia-Moreno E, B, Gray, J.G.
Deposit date:2019-04-12
Release date:2019-05-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Toward the computational design of protein crystals with improved resolution.
Acta Crystallogr D Struct Biol, 75, 2019
5JJI
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BU of 5jji by Molmil
Rho transcription termination factor bound to rU7 and 6 ADP-BeF3 molecules
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Thomsen, N.D, Lawson, M.R, Witkowsky, L.B, Qu, S, Berger, J.M.
Deposit date:2016-04-24
Release date:2016-11-16
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5JJL
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BU of 5jjl by Molmil
Rho transcription termination factor bound to rU8 and 5 ADP-BeF3 molecules
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
Authors:Thomsen, N.D, Lawson, M.R, Witkowsky, L.B, Qu, S, Berger, J.M.
Deposit date:2016-04-24
Release date:2016-11-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5HE9
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BU of 5he9 by Molmil
Bacterial initiation protein in complex with Phage inhibitor protein
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Helicase loader, ...
Authors:Hood, I.V, Berger, J.M.
Deposit date:2016-01-05
Release date:2016-06-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of inhibited replicative helicase loader from Staphylococcus aureus at 1.9 Angstrom resolution
To Be Published

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