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2UVS
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BU of 2uvs by Molmil
High Resolution Solid-state NMR structure of Kaliotoxin
Descriptor: POTASSIUM CHANNEL TOXIN ALPHA-KTX 3.1
Authors:Korukottu, J, Lange, A, Vijayan, V, Schneider, R, Pongs, O, Becker, S, Baldus, M, Zweckstetter, M.
Deposit date:2007-03-14
Release date:2008-05-27
Last modified:2020-01-15
Method:SOLID-STATE NMR
Cite:Conformational Plasticity in Ion Channel Recognition of a Peptide Toxin
To be Published
7ZJP
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BU of 7zjp by Molmil
Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106
Descriptor: 2-methyl-4-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-b]indole-7-carboxylic acid, SULFATE ION, Transcriptional enhancer factor TEF-1
Authors:Freire, F, Heinrich, T, Petersson, C, Schneider, R, Garg, S, Schwarz, D, Gunera, J, Seshire, A, Koetzner, L, Schlesiger, S, Musil, D, Schilke, H, Doerfel, B, Diehl, P, Boepple, P, Lemos, A.R, Sousa, P.M.F, Freire, F, Bandeiras, T.M, Carswell, E, Pearson, N, Sirohi, S, Hooker, M, Trivier, E, Broome, R, Balsiger, A, Crowden, A, Dillon, C, Wienke, D.
Deposit date:2022-04-11
Release date:2022-07-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 .
J.Med.Chem., 65, 2022
3ZFR
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BU of 3zfr by Molmil
Crystal structure of product-like, processed N-terminal protease Npro with iridium
Descriptor: HYDROXIDE ION, IRIDIUM (III) ION, MONOTHIOGLYCEROL, ...
Authors:Zogg, T, Sponring, M, Schindler, S, Koll, M, Schneider, R, Brandstetter, H, Auer, B.
Deposit date:2012-12-12
Release date:2013-05-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis
Structure, 21, 2013
3ZFQ
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BU of 3zfq by Molmil
Crystal structure of product-like, processed N-terminal protease Npro with mercury
Descriptor: MERCURY (II) ION, MONOTHIOGLYCEROL, N-TERMINAL PROTEASE NPRO
Authors:Zogg, T, Sponring, M, Schindler, S, Koll, M, Schneider, R, Brandstetter, H, Auer, B.
Deposit date:2012-12-12
Release date:2013-05-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis
Structure, 21, 2013
3ZFP
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BU of 3zfp by Molmil
Crystal structure of product-like, processed N-terminal protease Npro with internal His-Tag
Descriptor: CHLORIDE ION, MONOTHIOGLYCEROL, N-TERMINAL PROTEASE NPRO
Authors:Zogg, T, Sponring, M, Schindler, S, Koll, M, Schneider, R, Brandstetter, H, Auer, B.
Deposit date:2012-12-12
Release date:2013-05-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis
Structure, 21, 2013
3ZFT
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BU of 3zft by Molmil
Crystal structure of product-like, processed N-terminal protease Npro at pH 3
Descriptor: CHLORIDE ION, MONOTHIOGLYCEROL, N-TERMINAL PROTEASE NPRO
Authors:Zogg, T, Sponring, M, Schindler, S, Koll, M, Schneider, R, Brandstetter, H, Auer, B.
Deposit date:2012-12-12
Release date:2013-05-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis
Structure, 21, 2013
3ZFO
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BU of 3zfo by Molmil
Crystal structure of substrate-like, unprocessed N-terminal protease Npro mutant S169P
Descriptor: CHLORIDE ION, HYDROXIDE ION, MONOTHIOGLYCEROL, ...
Authors:Zogg, T, Sponring, M, Schindler, S, Koll, M, Schneider, R, Brandstetter, H, Auer, B.
Deposit date:2012-12-12
Release date:2013-05-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis
Structure, 21, 2013
3ZFU
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BU of 3zfu by Molmil
Crystal structure of substrate-like, unprocessed N-terminal protease Npro mutant S169P with sulphate
Descriptor: MONOTHIOGLYCEROL, N-TERMINAL PROTEASE NPRO, SULFATE ION
Authors:Zogg, T, Sponring, M, Schindler, S, Koll, M, Schneider, R, Brandstetter, H, Auer, B.
Deposit date:2012-12-12
Release date:2013-05-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis
Structure, 21, 2013
3ZFN
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BU of 3zfn by Molmil
Crystal structure of product-like, processed N-terminal protease Npro
Descriptor: CHLORIDE ION, MONOTHIOGLYCEROL, N-TERMINAL PROTEASE NPRO
Authors:Zogg, T, Sponring, M, Schindler, S, Koll, M, Schneider, R, Brandstetter, H, Auer, B.
Deposit date:2012-12-12
Release date:2013-05-15
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis
Structure, 21, 2013
5FGK
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BU of 5fgk by Molmil
CDK8-CYCC IN COMPLEX WITH 8-[3-(3-Amino-1H-indazol-6-yl)-5-chloro- pyridine-4-yl]-2,8-diaza-spiro[4.5]decan-1-one
Descriptor: 1,2-ETHANEDIOL, 8-[3-(3-azanyl-2~{H}-indazol-6-yl)-5-chloranyl-pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one, Cyclin-C, ...
Authors:Musil, D, Blagg, J, Mallinger, A.
Deposit date:2015-12-20
Release date:2016-02-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
J.Med.Chem., 59, 2016
5BNJ
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BU of 5bnj by Molmil
CDK8/CYCC IN COMPLEX WITH 8-{3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one
Descriptor: 8-{3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyridin-4-yl}-2,8-diazaspiro[4.5]decan-1-one, Cyclin-C, Cyclin-dependent kinase 8, ...
Authors:Musil, D, Blagg, J, Wienke, D.
Deposit date:2015-05-26
Release date:2015-10-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Nat.Chem.Biol., 11, 2015
3L8S
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BU of 3l8s by Molmil
Human p38 MAP Kinase in Complex with CP-547632
Descriptor: 3-[(4-bromo-2,6-difluorobenzyl)oxy]-5-{[(4-pyrrolidin-1-ylbutyl)carbamoyl]amino}isothiazole-4-carboxamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
Authors:Gruetter, C, Simard, J.R, Rauh, D.
Deposit date:2010-01-03
Release date:2010-03-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.
J.Am.Chem.Soc., 132, 2010
7PON
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BU of 7pon by Molmil
C TERMINAL DOMAIN OF NIPAH VIRUS PHOSPHOPROTEIN
Descriptor: Phosphoprotein
Authors:Yabukarski, F, Tarbouriech, N, Jamin, M, Bourhis, J.M.
Deposit date:2021-09-09
Release date:2022-04-20
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Dynamics of the C-terminal X Domain of Nipah and Hendra Viruses Controls the Attachment to the C-terminal Tail of the Nucleocapsid Protein.
J.Mol.Biol., 434, 2022
7PNO
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BU of 7pno by Molmil
C terminal domain of Nipah Virus Phosphoprotein fused to the Ntail alpha more of the Nucleoprotein.
Descriptor: Phosphoprotein, alpha MoRE of Nipah virus Nucleoprotein tail
Authors:Bourhis, J.M, Yabukaski, F, Tarbouriech, N, Jamin, M.
Deposit date:2021-09-07
Release date:2022-04-20
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural Dynamics of the C-terminal X Domain of Nipah and Hendra Viruses Controls the Attachment to the C-terminal Tail of the Nucleocapsid Protein.
J.Mol.Biol., 434, 2022
7OCV
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BU of 7ocv by Molmil
Human TNKS1 in complex with 3-[4-(1-Hydroxy-1-methyl-ethyl)-phenyl]-6-methyl-2H-pyrrolo[1,2-a]pyrazin-1-one
Descriptor: 6-methyl-3-[4-(2-oxidanylpropan-2-yl)phenyl]-4~{H}-pyrrolo[1,2-a]pyrazin-1-one, ACETATE ION, Poly [ADP-ribose] polymerase, ...
Authors:Musil, D, Lehmann, M, Buchstaller, H.-P.
Deposit date:2021-04-28
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.432 Å)
Cite:Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models.
J.Med.Chem., 64, 2021
5HBH
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BU of 5hbh by Molmil
CDK8-CYCC IN COMPLEX WITH 5-{5-Chloro-4-[1-(2-methoxy-ethyl)-1,8-diaza-spiro[4.5]dec-8-yl]-pyridin-3-yl}-1-methyl-1,3-dihydro-benzo[c]isothiazole 2,2-dioxide
Descriptor: 1,2-ETHANEDIOL, 5-[5-chloranyl-4-[1-(2-methoxyethyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3~{H}-2,1-benzothiazole 2,2-dioxide, Cyclin-C, ...
Authors:Musil, D, Blagg, J, Mallinger, A.
Deposit date:2015-12-31
Release date:2016-02-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
J.Med.Chem., 59, 2016
5HBE
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BU of 5hbe by Molmil
CDK8-CYCC IN COMPLEX WITH 8-[3-Chloro-5-(1-methyl-2,2-dioxo-2, 3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-pyridin- 4-yl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one
Descriptor: 1,2-ETHANEDIOL, 8-[3-chloranyl-5-[1-methyl-2,2-bis(oxidanylidene)-3~{H}-2,1-benzothiazol-5-yl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, Cyclin-C, ...
Authors:Musil, D, Blagg, J, Mallinger, A.
Deposit date:2015-12-31
Release date:2016-02-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
J.Med.Chem., 59, 2016
5I5Z
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BU of 5i5z by Molmil
CDK8-CYCC IN COMPLEX WITH 8-(1-Methyl-2,2-dioxo-2,3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-[1,6]naphthyridine-2-carboxylic acid methylamide
Descriptor: Cyclin-C, Cyclin-dependent kinase 8, FORMIC ACID, ...
Authors:Musil, D, Blagg, J, Mallinger, A.
Deposit date:2016-02-15
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.
Acs Med.Chem.Lett., 7, 2016
5HBJ
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BU of 5hbj by Molmil
CDK8-CYCC IN COMPLEX WITH 8-[2-Amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-pyridin-4-yl]-2,8-diaza-spiro[4.5]decan-1-one
Descriptor: 1,2-ETHANEDIOL, 8-[2-azanyl-3-chloranyl-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one, Cyclin-C, ...
Authors:Musil, D, Blagg, J, Mallinger, A.
Deposit date:2015-12-31
Release date:2016-02-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
J.Med.Chem., 59, 2016
3TZ7
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BU of 3tz7 by Molmil
Kinase domain of cSrc in complex with RL103
Descriptor: N-(4-{[4-({[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]amino}quinazolin-6-yl)-4-(dimethylamino)butanamide, Proto-oncogene tyrosine-protein kinase Src
Authors:Gruetter, C, Richters, A, Rauh, D.
Deposit date:2011-09-27
Release date:2012-10-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Overcoming Gatekeeper Mutations in cSrc and Abl by Hybrid Compound Design
To be Published
3TZ8
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BU of 3tz8 by Molmil
Kinase domain of cSrc in complex with RL104
Descriptor: N-(4-{[4-({[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]amino}quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide, Proto-oncogene tyrosine-protein kinase Src
Authors:Gruetter, C, Richters, A, Rauh, D.
Deposit date:2011-09-27
Release date:2012-10-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Overcoming Gatekeeper Mutations in cSrc and Abl by Hybrid Compound Design
To be Published
3TZ9
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BU of 3tz9 by Molmil
Kinase domain of cSrc in complex with RL130
Descriptor: 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-[4-(quinazolin-4-ylamino)phenyl]urea, Proto-oncogene tyrosine-protein kinase Src
Authors:Gruetter, C, Richters, A, Rauh, D.
Deposit date:2011-09-27
Release date:2012-10-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Overcoming Gatekeeper Mutations in cSrc and Abl by Hybrid Compound Design
To be Published
8P7D
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BU of 8p7d by Molmil
CryoEM structure of METTL6 tRNA SerRS complex in a 1:1:2 stoichiometry
Descriptor: MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, Serine tRNA, ...
Authors:Throll, P, Dolce, L.G, Kowalinski, E.
Deposit date:2023-05-30
Release date:2024-06-12
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural basis of tRNA recognition by the m 3 C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase.
Nat.Struct.Mol.Biol., 2024
8P7B
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BU of 8p7b by Molmil
CryoEM structure of METTL6 tRNA SerRS complex in a 1:2:2 stoichiometry
Descriptor: MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, Serine tRNA, ...
Authors:Throll, P, Dolce, L.G, Kowalinski, E.
Deposit date:2023-05-30
Release date:2024-06-12
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (2.42 Å)
Cite:Structural basis of tRNA recognition by the m 3 C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase.
Nat.Struct.Mol.Biol., 2024
8P7C
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BU of 8p7c by Molmil
CryoEM structure of METTL6 tRNA SerRS complex in a 2:2:2 stoichiometry
Descriptor: MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, Serine tRNA, ...
Authors:Throll, P, Dolce, L.G, Kowalinski, E.
Deposit date:2023-05-30
Release date:2024-06-12
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of tRNA recognition by the m 3 C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase.
Nat.Struct.Mol.Biol., 2024

 

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