3ZFU

Crystal structure of substrate-like, unprocessed N-terminal protease Npro mutant S169P with sulphate

Summary for 3ZFU

Related3ZFN 3ZFO 3ZFP 3ZFQ 3ZFR 3ZFT
DescriptorN-TERMINAL PROTEASE NPRO, MONOTHIOGLYCEROL, SULFATE ION, ... (4 entities in total)
Functional Keywordshydrolase, auto-processing cysteine protease, viral protease, in cis- cleavage, hydroxide-dependent catalysis, auto-proteolysis, immune modulation, host-pathogen interaction, convergent evolution
Biological sourcePESTIVIRUS STRAIN D32/00_HOBI
Total number of polymer chains1
Total molecular weight18600.32
Authors
Zogg, T.,Sponring, M.,Schindler, S.,Koll, M.,Schneider, R.,Brandstetter, H.,Auer, B. (deposition date: 2012-12-12, release date: 2013-05-15, Last modification date: 2013-06-19)
Primary citation
Zogg, T.,Sponring, M.,Schindler, S.,Koll, M.,Schneider, R.,Brandstetter, H.,Auer, B.
Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis
Structure, 21:929-, 2013
PubMed: 23643950 (PDB entries with the same primary citation)
DOI: 10.1016/J.STR.2013.04.003
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.76 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.253100.7%3.8%5.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution