5VP2 | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH MADUMYCIN II AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION | | Descriptor: | 23S Ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Osterman, I.A., Khabibullina, N.F., Komarova, E.S., Kasatsky, P., Kartsev, V.G., Bogdanov, A.A., Dontsova, O.A., Konevega, A.L., Sergiev, P.V., Polikanov, Y.S. | | Deposit date: | 2017-05-04 | | Release date: | 2017-06-28 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.
Nucleic Acids Res., 45, 2017
|
|
5W4K | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH KLEBSAZOLICIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.7A RESOLUTION | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Metelev, M., Osterman, I.A., Ghilarov, D., Khabibullina, N.F., Yakimov, A., Shabalin, K., Utkina, I., Travin, D.Y., Komarova, E.S., Serebryakova, M., Artamonova, T., Khodorkovskii, M., Konevega, A.L., Sergiev, P.V., Severinov, K., Polikanov, Y.S. | | Deposit date: | 2017-06-12 | | Release date: | 2017-08-30 | | Last modified: | 2018-06-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel.
Nat. Chem. Biol., 13, 2017
|
|
5WIS | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH METHYMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.7A RESOLUTION | | Descriptor: | 23S ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S. | | Deposit date: | 2017-07-20 | | Release date: | 2018-02-14 | | Last modified: | 2018-03-21 | | Method: | X-RAY DIFFRACTION (2.703 Å) | | Cite: | Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Nucleic Acids Res., 45, 2017
|
|
5WIT | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PIKROMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S. | | Deposit date: | 2017-07-20 | | Release date: | 2018-02-14 | | Last modified: | 2018-03-21 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Nucleic Acids Res., 45, 2017
|
|
6N9E | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH A SHORT SUBSTRATE MIMIC CC-PMN AND BOUND TO MRNA AND P-SITE TRNA AT 3.7A RESOLUTION | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ... | | Authors: | Melnikov, S.V., Khabibullina, N.F., Mairhofer, E., Vargas-Rodriguez, O., Reynolds, N.M., Micura, R., Soll, D., Polikanov, Y.S. | | Deposit date: | 2018-12-03 | | Release date: | 2018-12-12 | | Last modified: | 2018-12-19 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.
Nucleic Acids Res., 2018
|
|
6N9F | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH A SHORT SUBSTRATE MIMIC ACCA-DPHE AND BOUND TO MRNA AND P-SITE TRNA AT 3.7A RESOLUTION | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ... | | Authors: | Melnikov, S.V., Khabibullina, N.F., Mairhofer, E., Vargas-Rodriguez, O., Reynolds, N.M., Micura, R., Soll, D., Polikanov, Y.S. | | Deposit date: | 2018-12-03 | | Release date: | 2018-12-12 | | Last modified: | 2018-12-19 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.
Nucleic Acids Res., 2018
|
|
2L9U | |
