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2X9C
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BU of 2x9c by Molmil
Crystal structure of a soluble PrgI mutant from Salmonella Typhimurium
Descriptor: PROTEIN PRGI
Authors:Poyraz, O, Schmidt, H, Seidel, K, Delissen, F, Ader, C, Tenenboim, H, Goosmann, C, Laube, B, Thuenemann, A.F, Zychlinsky, A, Baldus, M, Lange, A, Griesinger, C, Kolbe, M.
Deposit date:2010-03-15
Release date:2010-06-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Protein Refolding is Required for Assembly of the Type Three Secretion Needle
Nat.Struct.Mol.Biol., 17, 2010
2KV7
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BU of 2kv7 by Molmil
NMR solution structure of a soluble PrgI mutant from Salmonella Typhimurium
Descriptor: Protein prgI
Authors:Schmidt, H, Poyraz, O, Seidel, K, Delissen, F, Ader, C, Tenenboim, H, Goosmann, C, Laube, B, Thuenemann, A.F, Zychlinski, A, Baldus, M, Lange, A, Griesinger, C, Kolbe, M.
Deposit date:2010-03-09
Release date:2010-06-16
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Protein refolding is required for assembly of the type three secretion needle.
Nat.Struct.Mol.Biol., 17, 2010
9C9Q
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BU of 9c9q by Molmil
Crystal structure of Chaetomium thermophilum Gcn2 HisRS-like domain
Descriptor: non-specific serine/threonine protein kinase
Authors:Bou-Nader, C, Bahmanjah, S, Zhang, J.
Deposit date:2024-06-14
Release date:2024-08-21
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Gcn2 structurally mimics and functionally repurposes the HisRS enzyme for the integrated stress response.
Proc.Natl.Acad.Sci.USA, 121, 2024
2X7L
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BU of 2x7l by Molmil
Implications of the HIV-1 Rev dimer structure at 3.2A resolution for multimeric binding to the Rev response element
Descriptor: FAB HEAVY CHAIN, FAB LIGHT CHAIN, PROTEIN REV
Authors:DiMattia, M.A, Watts, N.R, Stahl, S.J, Rader, C, Wingfield, P.T, Stuart, D.I, Steven, A.C, Grimes, J.M.
Deposit date:2010-03-01
Release date:2010-03-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Implications of the HIV-1 Rev Dimer Structure at 3. 2 A Resolution for Multimeric Binding to the Rev Response Element.
Proc.Natl.Acad.Sci.USA, 107, 2010
6EZA
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BU of 6eza by Molmil
Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K mutant
Descriptor: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Bou-Nader, C, Bregeon, D, Pecqueur, L, Vincent, G, Fontecave, M, Hamdane, D.
Deposit date:2017-11-14
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
6EZB
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BU of 6ezb by Molmil
Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain Q305K mutant
Descriptor: FLAVIN MONONUCLEOTIDE, GLYCEROL, SULFATE ION, ...
Authors:Bou-Nader, C, Bregeon, D, Pecqueur, L, Fontecave, M, Hamdane, D.
Deposit date:2017-11-14
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
6EZC
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BU of 6ezc by Molmil
Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K Q305K double mutant
Descriptor: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Bou-Nader, C, Bregeon, D, Vincent, G, Fontecave, M, Hamdane, D.
Deposit date:2017-11-14
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
4WFS
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BU of 4wfs by Molmil
Crystal Structure of tRNA-dihydrouridine(20) synthase catalytic domain
Descriptor: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, SULFATE ION, ...
Authors:Bou-Nader, C, Pecqueur, L, Kamah, A, Bregeon, D, Golinelli-Pimpaneau, B, Guimaraes, B.G, Fontecave, M, Hamdane, D.
Deposit date:2014-09-17
Release date:2015-10-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:An extended dsRBD is required for post-transcriptional modification in human tRNAs.
Nucleic Acids Res., 43, 2015
4WFT
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BU of 4wft by Molmil
Crystal structure of tRNA-dihydrouridine(20) synthase dsRBD domain
Descriptor: tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
Authors:Bou-Nader, C, Pecqueur, L, Kamah, A, Bregeon, D, Golinelli-Pimpaneau, B, Guimaraes, B.G, Fontecave, M, Hamdane, D.
Deposit date:2014-09-17
Release date:2015-10-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:An extended dsRBD is required for post-transcriptional modification in human tRNAs.
Nucleic Acids Res., 43, 2015
6OL3
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BU of 6ol3 by Molmil
Crystal structure of an adenovirus virus-associated RNA
Descriptor: Adenovirus Virus-Associated (VA) RNA I apical and central domains, POTASSIUM ION
Authors:Hood, I.V, Gordon, J.M, Bou-Nader, C, Henderson, F.V, Bahmanjah, S, Zhang, J.
Deposit date:2019-04-15
Release date:2019-07-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Crystal structure of an adenovirus virus-associated RNA.
Nat Commun, 10, 2019
6EI8
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BU of 6ei8 by Molmil
Crystal structure of human tRNA-dihydrouridine (20) synthase dsRBD F359A mutant
Descriptor: SULFATE ION, tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
Authors:Bou-Nader, C, Pecqueur, L, Hamdane, D.
Deposit date:2017-09-18
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Conformational Stability Adaptation of a Double-Stranded RNA-Binding Domain to Transfer RNA Ligand.
Biochemistry, 58, 2019
9C9R
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BU of 9c9r by Molmil
Crystal structure of Chaetomium thermophilum Gcn2 HisRS-like domain, F1090C/G1326S variant
Descriptor: non-specific serine/threonine protein kinase
Authors:Bou-Nader, C, Bahmanjah, S, Zhang, J.
Deposit date:2024-06-14
Release date:2024-08-21
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Gcn2 structurally mimics and functionally repurposes the HisRS enzyme for the integrated stress response.
Proc.Natl.Acad.Sci.USA, 121, 2024
5OC6
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BU of 5oc6 by Molmil
Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD in complex with a 22 nucleotide dsRNA
Descriptor: RNA, tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
Authors:Bou-nader, C, Pecqueur, L, Hamdane, D.
Deposit date:2017-06-29
Release date:2018-12-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.
Nucleic Acids Res., 47, 2019
5OC5
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BU of 5oc5 by Molmil
Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD K419A-K420A mutant
Descriptor: CHLORIDE ION, GLYCEROL, tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
Authors:Bou-nader, C, Pecqueur, L, Hamdane, D.
Deposit date:2017-06-29
Release date:2018-12-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.
Nucleic Acids Res., 47, 2019
5OC4
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BU of 5oc4 by Molmil
Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD R361A-R362A mutant
Descriptor: CACODYLATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Bou-nader, C, Pecqueur, L, Hamdane, D.
Deposit date:2017-06-29
Release date:2018-12-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.
Nucleic Acids Res., 47, 2019
7MRL
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BU of 7mrl by Molmil
Structure of HIV-1 matrix domain bound to human tRNALys3
Descriptor: HIV-1 matrix domain, MAGNESIUM ION, tRNA Lys3
Authors:Bou-Nader, C, Zhang, J.
Deposit date:2021-05-07
Release date:2021-08-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization.
Cell Host Microbe, 29, 2021
7TQA
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BU of 7tqa by Molmil
Crystal Structure of monoclonal S9.6 Fab
Descriptor: Fab S9.6 heavy chain, Fab S9.6 light chain, GLYCEROL, ...
Authors:Bou-Nader, C, Zhang, J.
Deposit date:2022-01-26
Release date:2022-03-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.328 Å)
Cite:Structural basis of R-loop recognition by the S9.6 monoclonal antibody.
Nat Commun, 13, 2022
7TQB
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BU of 7tqb by Molmil
Crystal structure of monoclonal S9.6 Fab bound to DNA-RNA hybrid
Descriptor: DNA, FAB S9.6 Heavy Chain, FAB S9.6 Light Chain, ...
Authors:Bou-Nader, C, Zhang, J.
Deposit date:2022-01-26
Release date:2022-03-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of R-loop recognition by the S9.6 monoclonal antibody.
Nat Commun, 13, 2022
5NL1
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BU of 5nl1 by Molmil
Shigella IpaA-VBS3/TBS in complex with the Talin VBS1 domain 488-512
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Invasin IpaA, ...
Authors:Bou-Nader, C, Pecqueur, L, Valencia-Gallardo, C, Fontecave, M, Tran Van Nhieu, G.
Deposit date:2017-04-03
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Shigella IpaA Binding to Talin Stimulates Filopodial Capture and Cell Adhesion.
Cell Rep, 26, 2019
6OSV
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BU of 6osv by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: Antibody heavy chain variable region, Antibody light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-02
Release date:2020-04-01
Last modified:2020-05-13
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSH
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BU of 6osh by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: Antibody Light chain variable region, Antibody heavy chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-01
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.117 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSN
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BU of 6osn by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: ACETATE ION, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-01
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.083 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6EI9
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BU of 6ei9 by Molmil
Crystal structure of E. coli tRNA-dihydrouridine synthase B (DusB)
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Bou-Nader, C, Hamdane, D.
Deposit date:2017-09-18
Release date:2018-01-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Unveiling structural and functional divergences of bacterial tRNA dihydrouridine synthases: perspectives on the evolution scenario.
Nucleic Acids Res., 46, 2018
6BA5
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BU of 6ba5 by Molmil
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain Heavy chain, antibody R11, ...
Authors:Park, H, Rader, C.
Deposit date:2017-10-12
Release date:2018-06-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BAN
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BU of 6ban by Molmil
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain R11 Heavy chain, Variable domain of R11 Light Chain
Authors:Park, H, Rader, C.
Deposit date:2017-10-14
Release date:2018-06-13
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018

 

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