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6Y2G
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CRYSTAL STRUCTURE (ORTHORHOMBIC FORM) OF THE COMPLEX RESULTING FROM THE REACTION BETWEEN SARS-COV-2 (2019-NCOV) MAIN PROTEASE AND TERT-BUTYL (1-((S)-1-(((S)-4-(BENZYLAMINO)-3,4-DIOXO-1-((S)-2-OXOPYRROLIDIN-3-YL)BUTAN-2-YL)AMINO)-3-CYCLOPROPYL-1-OXOPROPAN-2-YL)-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)CARBAMATE (ALPHA-KETOAMIDE 13B)
Descriptor:Replicase polyprotein 1ab, GLYCINE, ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate
Authors:Zhang, L., Lin, D., Sun, X., Hilgenfeld, R.
Deposit date:2020-02-15
Release date:2020-03-04
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors.
Science, 368, 2020
6Y2F
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CRYSTAL STRUCTURE (MONOCLINIC FORM) OF THE COMPLEX RESULTING FROM THE REACTION BETWEEN SARS-COV-2 (2019-NCOV) MAIN PROTEASE AND TERT-BUTYL (1-((S)-1-(((S)-4-(BENZYLAMINO)-3,4-DIOXO-1-((S)-2-OXOPYRROLIDIN-3-YL)BUTAN-2-YL)AMINO)-3-CYCLOPROPYL-1-OXOPROPAN-2-YL)-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)CARBAMATE (ALPHA-KETOAMIDE 13B)
Descriptor:Replicase polyprotein 1ab, DIMETHYL SULFOXIDE, ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate
Authors:Zhang, L., Lin, D., Sun, X., Hilgenfeld, R.
Deposit date:2020-02-15
Release date:2020-03-04
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors.
Science, 368, 2020
6Y2E
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CRYSTAL STRUCTURE OF THE FREE ENZYME OF THE SARS-COV-2 (2019-NCOV) MAIN PROTEASE
Descriptor:Replicase polyprotein 1ab
Authors:Zhang, L., Sun, X., Hilgenfeld, R.
Deposit date:2020-02-15
Release date:2020-03-04
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors.
Science, 368, 2020
6V5D
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EROS3 RDC AND NOE DERIVED UBIQUITIN ENSEMBLE
Descriptor:Ubiquitin
Authors:Lange, O.F., Lakomek, N.A., Smith, C.A., Griesinger, C., de Groot, B.L.
Deposit date:2019-12-04
Release date:2020-01-01
Last modified:2020-02-26
Method:SOLUTION NMR
Cite:Enhancing NMR derived ensembles with kinetics on multiple timescales.
J.Biomol.Nmr, 74, 2020
6R99
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CRYSTAL STRUCTURE OF HUMAN CLN PROTEIN 5 (CEROID LIPOFUSCINOSIS NEURONAL PROTEIN 5)
Descriptor:Ceroid-lipofuscinosis neuronal protein 5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Luebben, A.V., Sheldrick, G.M.
Deposit date:2019-04-03
Release date:2020-04-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The CLN5 structure reveals a lysosomal protease with important role in neurodegeneration
To Be Published
6QD8
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EM STRUCTURE OF A EBOV-GP BOUND TO 4M0368 NEUTRALIZING ANTIBODY
Descriptor:Light chain, Envelope glycoprotein,Virion spike glycoprotein,EBOV-GP1, Envelope glycoprotein, ...
Authors:Diskin, R., Cohen-Dvashi, H.
Deposit date:2019-01-01
Release date:2019-10-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:rVSV-ZEBOV induces a polyclonal and convergent B cell response with potent Ebola virus-neutralizing antibodies
Nat.Med. (N.Y.), 2019
6QD7
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EM STRUCTURE OF A EBOV-GP BOUND TO 3T0331 NEUTRALIZING ANTIBODY
Descriptor:Light chain, Heavy chain, Envelope glycoprotein,Virion spike glycoprotein,EBOV-GP1, ...
Authors:Diskin, R., Cohen-Dvashi, H.
Deposit date:2019-01-01
Release date:2019-10-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV.
Nat. Med., 25, 2019
6QCU
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CRYSTAL STRUCTURE OF A FAB PORTION OF THE ANTI EBOV 3T0331 ANTIBODY
Descriptor:Light chain, Heavy chain, SULFATE ION
Authors:Diskin, R., Cohen-Dvashi, H.
Deposit date:2018-12-31
Release date:2019-10-02
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:rVSV-ZEBOV induces a polyclonal and convergent B cell response with potent Ebola virus-neutralizing antibodies
Nat.Med. (N.Y.), 2019
6I42
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STRUCTURE OF THE ALPHA-SYNUCLEIN PRENAC/CYCLOPHILIN A-COMPLEX
Descriptor:Peptidyl-prolyl cis-trans isomerase A, Alpha-synuclein
Authors:Favretto, F., Zweckstetter, M., Becker, S.
Deposit date:2018-11-08
Release date:2020-02-19
Last modified:2020-04-01
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:The Molecular Basis of the Interaction of Cyclophilin A with alpha-Synuclein.
Angew.Chem.Int.Ed.Engl., 59, 2020
6GEZ
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THE STRUCTURE OF TWITCH-2B N532F
Descriptor:Green fluorescent protein,Optimized Ratiometric Calcium Sensor,Green fluorescent protein,Green fluorescent protein, CALCIUM ION, FORMIC ACID
Authors:Trigo Mourino, P., Paulat, M., Thestrup, T., Griesbeck, O., Griesinger, C., Becker, S.
Deposit date:2018-04-27
Release date:2019-08-21
Last modified:2019-09-11
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Dynamic tuning of FRET in a green fluorescent protein biosensor.
Sci Adv, 5, 2019
6GEL
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THE STRUCTURE OF TWITCH-2B
Descriptor:Green fluorescent protein,Optimized Ratiometric Calcium Sensor,Green fluorescent protein,Green fluorescent protein, CALCIUM ION, GLYCEROL, ...
Authors:Trigo Mourino, P., Paulat, M., Thestrup, T., Griesbeck, O., Griesinger, C., Becker, S.
Deposit date:2018-04-26
Release date:2019-08-21
Last modified:2019-09-11
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Dynamic tuning of FRET in a green fluorescent protein biosensor.
Sci Adv, 5, 2019
6FCG
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CRYSTAL STRUCTURE OF AN ENDO-LAMINARINASE FROM FORMOSA HEL1_33_131
Descriptor:Glycoside hydrolase, GH17 family, CALCIUM ION
Authors:Becker, S., Robb, C.S., Hehemann, J.H.
Deposit date:2017-12-20
Release date:2018-12-26
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Adaptive mechanisms that provide competitive advantages to marine bacteroidetes during microalgal blooms.
ISME J, 12, 2018
6EHM
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MODEL OF THE EBOLA VIRUS NUCLEOCAPSID SUBUNIT FROM RECOMBINANT VIRUS-LIKE PARTICLES
Descriptor:Nucleoprotein, Membrane-associated protein VP24
Authors:Wan, W., Kolesnikova, L., Clarke, M., Koehler, A., Noda, T., Becker, S., Briggs, J.A.G.
Deposit date:2017-09-13
Release date:2017-11-08
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Structure and assembly of the Ebola virus nucleocapsid.
Nature, 551, 2017
6EHL
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MODEL OF THE EBOLA VIRUS NUCLEOPROTEIN IN RECOMBINANT NUCLEOCAPSID-LIKE ASSEMBLIES
Descriptor:Nucleoprotein
Authors:Wan, W., Kolesnikova, L., Clarke, M., Koehler, A., Noda, T., Becker, S., Briggs, J.A.G.
Deposit date:2017-09-13
Release date:2017-11-08
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Structure and assembly of the Ebola virus nucleocapsid.
Nature, 551, 2017
5NWX
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INSIGHT INTO THE MOLECULAR RECOGNITION MECHANISM OF THE COACTIVATOR NCOA1 BY STAT6
Descriptor:Nuclear receptor coactivator 1, Signal transducer and activator of transcription 6
Authors:Russo, L., Giller, K., Pfitzner, E., Griesinger, C., Becker, S.
Deposit date:2017-05-08
Release date:2017-12-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6.
Sci Rep, 7, 2017
5NWM
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INSIGHT INTO THE MOLECULAR RECOGNITION MECHANISM OF THE COACTIVATOR NCOA1 BY STAT6
Descriptor:Nuclear receptor coactivator 1, Signal transducer and activator of transcription 6
Authors:Russo, L., Becker, S., Griesinger, C.
Deposit date:2017-05-06
Release date:2017-12-06
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6.
Sci Rep, 7, 2017
5JDP
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E73V MUTANT OF THE HUMAN VOLTAGE-DEPENDENT ANION CHANNEL
Descriptor:Voltage-dependent anion-selective channel protein 1
Authors:Jaremko, M., Jaremko, L., Villinger, S., Schmidt, C., Giller, K., Griesinger, C., Becker, S., Zweckstetter, M.
Deposit date:2016-04-17
Release date:2016-08-10
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:High-Resolution NMR Determination of the Dynamic Structure of Membrane Proteins.
Angew.Chem.Int.Ed.Engl., 55, 2016
5FQ1
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STRUCTURE OF THE CYTOPLASMIC PAS DOMAIN OF THE GEOBACILLUS THERMODENITRIFICANS HISTIDINE KINASE CITA
Descriptor:HISTIDINE KINASE, GLYCEROL, PHOSPHATE ION
Authors:Schomburg, B., Giller, K., Becker, S.
Deposit date:2015-12-03
Release date:2017-01-11
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Cryogenic optical localization provides 3D protein structure data with Angstrom resolution.
Nat. Methods, 14, 2017
5C58
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A DOUBLE MUTANT OF SERRATIA MARCESCENS HEMOPHORE RECEPTOR HASR IN COMPLEX WITH ITS HEMOPHORE HASA AND HEME
Descriptor:HasR protein, Hemophore HasA, PROTOPORPHYRIN IX CONTAINING FE
Authors:Becker, S., Diederichs, K., Welte, W.
Deposit date:2015-06-19
Release date:2016-06-29
Last modified:2020-04-08
Method:X-RAY DIFFRACTION (2.795 Å)
Cite:Binding of HasA by its transmembrane receptor HasR follows a conformational funnel mechanism.
Eur.Biophys.J., 49, 2020
5ABS
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CRYSTAL STRUCTURE OF THE C-TERMINAL COILED-COIL DOMAIN OF CIN85 IN SPACE GROUP P321
Descriptor:SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1, ZINC ION
Authors:Wong, L., Habeck, M., Griesinger, C., Becker, S.
Deposit date:2015-08-07
Release date:2016-07-13
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:The Adaptor Protein Cin85 Assembles Intracellular Signaling Clusters for B Cell Activation.
Sci.Signal., 9, 2016
4ZG4
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MYOSIN VC PRE-POWERSTROKE
Descriptor:myosin-Vc, MAGNESIUM ION, VANADATE ION, ...
Authors:Ropars, V., Pylypenko, O., Sweeney, L., Houdusse, A.
Deposit date:2015-04-22
Release date:2016-03-23
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Force-producing ADP state of myosin bound to actin.
Proc.Natl.Acad.Sci.USA, 113, 2016
4YXS
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CAMP-DEPENDENT PROTEIN KINASE PKA CATALYTIC SUBUNIT WITH PKI-5-24
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, N-BENZYL-9H-PURIN-6-AMINE
Authors:Schiffer, A., Wendt, K.U.
Deposit date:2015-03-23
Release date:2015-05-20
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles.
Angew.Chem.Int.Ed.Engl., 54, 2015
4YXR
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CRYSTAL STRUCTURE OF PKA IN COMPLEX WITH INHIBITOR.
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 3-methyl-2H-indazole
Authors:Schiffer, A., Wendt, K.U.
Deposit date:2015-03-23
Release date:2015-05-27
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles.
Angew.Chem.Int.Ed.Engl., 54, 2015
4UN2
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CRYSTAL STRUCTURE OF THE UBA DOMAIN OF DSK2 IN COMPLEX WITH UBIQUITIN
Descriptor:UBIQUITIN, UBIQUITIN DOMAIN-CONTAINING PROTEIN DSK2
Authors:Michielssens, S., Peters, J.H., Ban, D., Pratihar, S., Seeliger, D., Sharma, M., Giller, K., Sabo, T.M., Becker, S., Lee, D., Griesinger, C., de Groot, B.L.
Deposit date:2014-05-23
Release date:2014-08-27
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:A Designed Conformational Shift to Control Protein Binding Specificity.
Angew.Chem.Int.Ed.Engl., 53, 2014
4MIV
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CRYSTAL STRUCTURE OF SULFAMIDASE, CRYSTAL FORM L
Descriptor:N-sulphoglucosamine sulphohydrolase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Sidhu, N.S., Uson, I., Schreiber, K., Proepper, K., Becker, S., Sheldrick, G.M., Gaertner, J., Kraetzner, R., Steinfeld, R.
Deposit date:2013-09-02
Release date:2014-05-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of sulfamidase provides insight into the molecular pathology of mucopolysaccharidosis IIIA.
Acta Crystallogr.,Sect.D, 70, 2014
167327
数据于2020-08-05公开中