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2XI5
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BU of 2xi5 by Molmil
N-terminal endonuclease domain of La Crosse virus L-protein
Descriptor: MANGANESE (II) ION, RNA POLYMERASE L
Authors:Reguera, J, Weber, F, Cusack, S.
Deposit date:2010-06-28
Release date:2010-10-06
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral CAP-Dependent Transcription.
Plos Pathog., 6, 2010
2XI7
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BU of 2xi7 by Molmil
N-terminal endonuclease domain of La Crosse virus L-protein
Descriptor: 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MANGANESE (II) ION, RNA POLYMERASE L
Authors:Reguera, J, Weber, F, Cusack, S.
Deposit date:2010-06-28
Release date:2010-10-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral CAP-Dependent Transcription.
Plos Pathog., 6, 2010
8PK7
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BU of 8pk7 by Molmil
Helical reconstruction of CHIKV nsP3 helical scaffolds
Descriptor: Non-structural protein 3, ZINC ION
Authors:Reguera, J, Hons, M, Zimberger, C, Ptchelkine, D, Jones, R, Desfosses, A.
Deposit date:2023-06-25
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.52 Å)
Cite:The alphavirus nsP3 protein forms helical tubular scaffolds important for viral replication and particle assembly
To Be Published
8PHZ
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BU of 8phz by Molmil
Helical reconstruction of CHIKV nsP3 helical scaffolds
Descriptor: Non-structural protein 3, ZINC ION
Authors:Reguera, J, Hons, M, Zimberger, C, Ptchelkine, D, Jones, R, Desfosses, A.
Deposit date:2023-06-20
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.35 Å)
Cite:The alphavirus nsP3 protein forms helical tubular scaffolds important for viral replication and particle assembly
To be published
5IZE
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BU of 5ize by Molmil
Hantaan virus L protein cap-snatching endonuclease
Descriptor: MANGANESE (III) ION, RNA-directed RNA polymerase L
Authors:Reguera, J, Cusack, S.
Deposit date:2016-03-25
Release date:2016-06-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.
Plos Pathog., 12, 2016
5IZH
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BU of 5izh by Molmil
Lassa virus L protein cap-snatching endonuclease. apo form
Descriptor: RNA-directed RNA polymerase L
Authors:Reguera, J, Cusack, S.
Deposit date:2016-03-25
Release date:2016-06-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.
Plos Pathog., 12, 2016
4BGP
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BU of 4bgp by Molmil
Crystal structure of La Crosse virus nucleoprotein
Descriptor: GLYCEROL, NUCLEOPROTEIN, SULFATE ION
Authors:Reguera, J, Malet, H, Weber, F, Cusack, S.
Deposit date:2013-03-28
Release date:2013-04-24
Last modified:2013-05-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Encapsidation of Genomic RNA by La Crosse Orthobunyavirus Nucleoprotein
Proc.Natl.Acad.Sci.USA, 110, 2013
4BHH
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BU of 4bhh by Molmil
Crystal structure of tetramer of La Crosse virus nucleoprotein in complex with ssRNA
Descriptor: NUCLEOPROTEIN, POLY-URIDINE 45-MER
Authors:Reguera, J, Malet, H, Weber, F, Cusack, S.
Deposit date:2013-04-03
Release date:2013-04-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural Basis for Encapsidation of Genomic RNA by La Crosse Orthobunyavirus Nucleoprotein.
Proc.Natl.Acad.Sci.USA, 110, 2013
4F2M
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BU of 4f2m by Molmil
Crystal structure of a TGEV coronavirus Spike fragment in complex with the TGEV neutralizing monoclonal antibody 1AF10
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, ...
Authors:Reguera, J, Santiago, C, Mudgal, G, Ordono, D, Enjuanes, L, Casasnovas, J.M.
Deposit date:2012-05-08
Release date:2012-08-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.
Plos Pathog., 8, 2012
5J1N
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BU of 5j1n by Molmil
Lassa virus L protein cap-snatching endonuclease. Bound to one manganese ion
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, MANGANESE (III) ION, RNA-directed RNA polymerase L
Authors:Reguera, J, Cusack, S.
Deposit date:2016-03-29
Release date:2016-06-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.
Plos Pathog., 12, 2016
5J1P
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BU of 5j1p by Molmil
Lassa virus L protein cap-snatching endonuclease. Bound to two manganese ions
Descriptor: MANGANESE (III) ION, RNA-directed RNA polymerase L
Authors:Reguera, J, Cusack, S.
Deposit date:2016-03-29
Release date:2016-06-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.
Plos Pathog., 12, 2016
5AMR
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BU of 5amr by Molmil
Structure of the La Crosse Bunyavirus polymerase in complex with the 3' viral RNA
Descriptor: RNA, RNA POLYMERASE L
Authors:Reguera, J, Gerlach, P, Cusack, S.
Deposit date:2015-03-12
Release date:2015-06-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structural Insights Into Bunyavirus Replication and its Regulation by the Vrna Promoter.
Cell(Cambridge,Mass.), 161, 2015
5AMQ
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BU of 5amq by Molmil
Structure of the La Crosse Bunyavirus polymerase in complex with the 3' and 5' viral RNA
Descriptor: RNA, RNA POLYMERASE L
Authors:Reguera, J, Gerlach, P, Cusack, S.
Deposit date:2015-03-12
Release date:2015-06-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights Into Bunyavirus Replication and its Regulation by the Vrna Promoter.
Cell, 161, 2015
4F5C
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BU of 4f5c by Molmil
Crystal structure of the spike receptor binding domain of a porcine respiratory coronavirus in complex with the pig aminopeptidase N ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ...
Authors:Santiago, C, Reguera, J, Gaurav, M, Ordono, D, Enjuanes, L, Casasnovas, J.M.
Deposit date:2012-05-13
Release date:2012-08-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.
Plos Pathog., 8, 2012
6QW5
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BU of 6qw5 by Molmil
Structure and function of the toscana virus cap snatching endonuclease
Descriptor: 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MANGANESE (II) ION, RNA-dependent RNA polymerase, ...
Authors:Reguera, J, Jones, R, Bragagniolo, G, Lessoued, S, Mate, M.
Deposit date:2019-03-05
Release date:2019-09-25
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.988 Å)
Cite:Structure and function of the Toscana virus cap-snatching endonuclease.
Nucleic Acids Res., 47, 2019
6QVV
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BU of 6qvv by Molmil
Structure and function of phenuiviridae cap snatching endonucleases
Descriptor: GLYCEROL, MANGANESE (III) ION, RNA-dependent RNA polymerase, ...
Authors:Reguera, J, Jones, R, Bragagniolo, G, Lessoued, S, Mate, M.
Deposit date:2019-03-05
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and function of the Toscana virus cap-snatching endonuclease.
Nucleic Acids Res., 47, 2019
6QW0
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BU of 6qw0 by Molmil
Structure and function of toscana virus cap snatching endonucleases
Descriptor: GLYCEROL, MANGANESE (III) ION, RNA-dependent RNA polymerase, ...
Authors:Reguera, J, Jones, R, Bragagniolo, G, Lessoued, S, Mate, M.
Deposit date:2019-03-05
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure and function of the Toscana virus cap-snatching endonuclease.
Nucleic Acids Res., 47, 2019
6Z0U
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BU of 6z0u by Molmil
CryoEM structure of the Chikungunya virus nsP1 complex
Descriptor: Polyprotein P1234, ZINC ION
Authors:Reguera, J, Jones, R, Arranz-Avila, R.
Deposit date:2020-05-11
Release date:2020-10-14
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Capping pores of alphavirus nsP1 gate membranous viral replication factories.
Nature, 589, 2021
6Z0V
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BU of 6z0v by Molmil
CryoEM structure of the Chikungunya virus nsP1 complex
Descriptor: Polyprotein P1234, ZINC ION
Authors:Reguera, J, Jones, R, Arranz-Avila, R.
Deposit date:2020-05-11
Release date:2020-10-14
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Capping pores of alphavirus nsP1 gate membranous viral replication factories.
Nature, 589, 2021
8AXV
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BU of 8axv by Molmil
Structure of an open form of CHIKV nsP1 capping pores
Descriptor: 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one, ZINC ION, mRNA-capping enzyme nsP1
Authors:Reguera, J, Jones, R, Hons, M.
Deposit date:2022-09-01
Release date:2023-03-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores.
Proc.Natl.Acad.Sci.USA, 120, 2023
5MUS
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BU of 5mus by Molmil
Structure of the C-terminal domain of a reptarenavirus L protein
Descriptor: CHLORIDE ION, GLYCEROL, L protein
Authors:Rosenthal, M, Gogrefe, N, Reguera, J, Vogel, D, Rauschenberger, B, Cusack, S, Gunther, S, Reindl, S.
Deposit date:2017-01-14
Release date:2017-05-17
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.009 Å)
Cite:Structural insights into reptarenavirus cap-snatching machinery.
PLoS Pathog., 13, 2017
6I2N
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BU of 6i2n by Molmil
Helical RNA-bound Hantaan virus nucleocapsid
Descriptor: Nucleoprotein, RNA (5'-R(P*UP*UP*U)-3')
Authors:Arragain, B, Reguera, J, Desfosses, A, Gutsche, I, Schoehn, G, Malet, H.
Deposit date:2018-11-01
Release date:2019-01-23
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms.
Elife, 8, 2019
7PLR
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BU of 7plr by Molmil
Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound Baloxavir
Descriptor: Baloxavir acid, FORMIC ACID, GLYCEROL, ...
Authors:Feracci, M, Hernandez, S, Vincentelli, R, Ferron, F, Reguera, J, Canard, B, Alvarez, K.
Deposit date:2021-09-01
Release date:2022-09-14
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options.
Iucrj, 11, 2024
7OA4
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BU of 7oa4 by Molmil
Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound L-742,001
Descriptor: (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, FORMIC ACID, MANGANESE (II) ION, ...
Authors:Feracci, M, Hernandez, S, Vincentelli, R, Ferron, F, Reguera, J, Canard, B, Alvarez, K.
Deposit date:2021-04-19
Release date:2022-08-03
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options.
Iucrj, 11, 2024
5MUY
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BU of 5muy by Molmil
Structure of a C-terminal domain of a reptarenavirus L protein with m7GTP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, L protein
Authors:Rosenthal, M, Gogrefe, N, Reguera, J, Vogel, D, Rauschenberger, B, Cusack, S, Gunther, S, Reindl, S.
Deposit date:2017-01-14
Release date:2017-05-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural insights into reptarenavirus cap-snatching machinery.
PLoS Pathog., 13, 2017

 

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