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1CTN
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BU of 1ctn by Molmil
CRYSTAL STRUCTURE OF A BACTERIAL CHITINASE AT 2.3 ANGSTROMS RESOLUTION
Descriptor: CHITINASE A
Authors:Perrakis, A, Tews, I, Dauter, Z, Wilson, K.S, Vorgias, C.E.
Deposit date:1994-10-10
Release date:1995-02-07
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a bacterial chitinase at 2.3 A resolution.
Structure, 2, 1994
6QCG
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BU of 6qcg by Molmil
PCNA complex with Cdt1 N-terminal PIP-box peptide
Descriptor: DNA replication factor Cdt1, Proliferating cell nuclear antigen
Authors:Perrakis, A, von Castelmur, E.
Deposit date:2018-12-28
Release date:2019-01-23
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2E3 ligase activity to Cdt1.
Life Sci Alliance, 1, 2018
8ARF
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BU of 8arf by Molmil
Crystal structure of the N-terminal parallel dimeric coiled-coil region of the human kinetochore associated protein Spindly
Descriptor: Protein Spindly
Authors:Perrakis, A, Ahmad, M.U.
Deposit date:2022-08-16
Release date:2022-09-07
Last modified:2022-09-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin.
J.Cell Biol., 221, 2022
2KLS
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BU of 2kls by Molmil
Apo-form of the second Ca2+ binding domain of NCX1.4
Descriptor: Sodium/calcium exchanger 1
Authors:Hilge, M, Aelen, J, Foarce, A, Perrakis, A, Vuister, G.W.
Deposit date:2009-07-08
Release date:2009-08-18
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism.
Proc.Natl.Acad.Sci.USA, 106, 2009
3KJY
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BU of 3kjy by Molmil
Crystal structure of reduced HOMO SAPIENS CLIC3
Descriptor: Chloride intracellular channel protein 3, SULFATE ION
Authors:Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A.
Deposit date:2009-11-04
Release date:2009-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
7P0K
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BU of 7p0k by Molmil
Crystal structure of Autotaxin (ENPP2) with 18F-labeled positron emission tomography ligand
Descriptor: 2-[[2-ethyl-6-[4-[2-[(3~{R})-3-fluoranylpyrrolidin-1-yl]-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-2,3-dihydro-1,3-thiazole-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Salgado-Polo, F, Shao, T, Xiao, Z, Van, R, Chen, J, Rong, J, Haider, A, Shao, Y, Josephson, L, Perrakis, A, Liang, S.H.
Deposit date:2021-06-29
Release date:2022-07-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Imaging Autotaxin In Vivo with 18 F-Labeled Positron Emission Tomography Ligands
J Med Chem, 64, 2021
6NVQ
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BU of 6nvq by Molmil
Crystal structure of the VASH1-SVBP complex
Descriptor: GLYCEROL, Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1
Authors:Adamopoulos, A, Perrakis, A, Heidebrecht, T.
Deposit date:2019-02-05
Release date:2019-05-22
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.
Nat.Struct.Mol.Biol., 26, 2019
2XR9
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BU of 2xr9 by Molmil
Crystal structure of Autotaxin (ENPP2)
Descriptor: CALCIUM ION, ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, IODIDE ION, ...
Authors:Kamtekar, S, Hausmann, J, Day, J.E, Christodoulou, E, Perrakis, A.
Deposit date:2010-09-13
Release date:2011-01-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis of substrate discrimination and integrin binding by autotaxin.
Nat. Struct. Mol. Biol., 18, 2011
1QBB
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BU of 1qbb by Molmil
BACTERIAL CHITOBIASE COMPLEXED WITH CHITOBIOSE (DINAG)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHITOBIASE, SULFATE ION
Authors:Tews, I, Perrakis, A, Oppenheim, A, Dauter, Z, Wilson, K.S, Vorgias, C.E.
Deposit date:1996-06-07
Release date:1997-02-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease.
Nat.Struct.Biol., 3, 1996
1QBA
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BU of 1qba by Molmil
BACTERIAL CHITOBIASE, GLYCOSYL HYDROLASE FAMILY 20
Descriptor: CHITOBIASE, SULFATE ION
Authors:Tews, I, Perrakis, A, Oppenheim, A, Dauter, Z, Wilson, K.S, Vorgias, C.E.
Deposit date:1996-06-06
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease.
Nat.Struct.Biol., 3, 1996
3G73
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BU of 3g73 by Molmil
Structure of the FOXM1 DNA binding
Descriptor: DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(P*TP*TP*CP*GP*GP*GP*CP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*AP*T)-3'), Forkhead box protein M1, ...
Authors:Littler, D.R, Perrakis, A, Hibbert, R.G, Medema, R.H.
Deposit date:2009-02-09
Release date:2009-03-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
Nucleic Acids Res., 2010
2WVR
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BU of 2wvr by Molmil
Human Cdt1:Geminin complex
Descriptor: DNA REPLICATION FACTOR CDT1, GEMININ
Authors:De Marco, V, Perrakis, A.
Deposit date:2009-10-19
Release date:2009-10-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Quaternary Structure of the Human Cdt1-Geminin Complex Regulates DNA Replication Licensing.
Proc.Natl.Acad.Sci.USA, 106, 2009
7Z5G
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BU of 7z5g by Molmil
human apo MATCAP
Descriptor: Uncharacterized protein KIAA0895-like
Authors:Bak, J, Adamoupolos, A, Heidebrecht, T, Perrakis, A.
Deposit date:2022-03-09
Release date:2022-05-11
Last modified:2022-06-01
Method:X-RAY DIFFRACTION (2.113 Å)
Cite:Posttranslational modification of microtubules by the MATCAP detyrosinase.
Science, 376, 2022
7Z5H
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BU of 7z5h by Molmil
human Zn MATCAP
Descriptor: Uncharacterized protein KIAA0895-like, ZINC ION
Authors:Bak, J, Adamopoulos, A, Heidebrecht, T, Perrakis, A.
Deposit date:2022-03-09
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Posttranslational modification of microtubules by the MATCAP detyrosinase.
Science, 376, 2022
7Z6S
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BU of 7z6s by Molmil
MATCAP bound to a human 14 protofilament microtubule
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bak, J, Perrakis, A.
Deposit date:2022-03-14
Release date:2022-05-11
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Posttranslational modification of microtubules by the MATCAP detyrosinase.
Science, 376, 2022
1VYB
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BU of 1vyb by Molmil
Endonuclease domain of human LINE1 ORF2p
Descriptor: GLYCEROL, ORF2 CONTAINS A REVERSE TRANSCRIPTASE DOMAIN, SULFATE ION, ...
Authors:Weichenrieder, O, Repanas, K, Perrakis, A.
Deposit date:2004-04-25
Release date:2004-06-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon.
Structure, 12, 2004
7Z0N
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BU of 7z0n by Molmil
Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators
Descriptor: CALCIUM ION, GLYCEROL, IODIDE ION, ...
Authors:Salgado-Polo, F, Clark, J.M, Macdonald, S.J.F, Barrett, T.N, Perrakis, A, Jamieson, A.
Deposit date:2022-02-23
Release date:2022-05-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators.
J.Med.Chem., 65, 2022
2CKL
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BU of 2ckl by Molmil
Ring1b-Bmi1 E3 catalytic domain structure
Descriptor: IODIDE ION, POLYCOMB GROUP RING FINGER PROTEIN 4, UBIQUITIN LIGASE PROTEIN RING2, ...
Authors:Buchwald, G, van der Stoop, P, Weichenrieder, O, Perrakis, A, van Lohuizen, M, Sixma, T.K.
Deposit date:2006-04-20
Release date:2006-05-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and E3-Ligase Activity of the Ring-Ring Complex of Polycomb Proteins Bmi1 and Ring1B.
Embo J., 25, 2006
3FY7
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BU of 3fy7 by Molmil
Crystal structure of homo sapiens CLIC3
Descriptor: Chloride intracellular channel protein 3, SULFATE ION
Authors:Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A.
Deposit date:2009-01-22
Release date:2009-02-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
6FPV
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BU of 6fpv by Molmil
A llama-derived JBP1-targeting nanobody
Descriptor: GLYCEROL, Nanobody
Authors:van Beusekom, B, Adamopoulos, A, Heidebrecht, T, Joosten, R.P, Perrakis, A.
Deposit date:2018-02-12
Release date:2018-10-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1.
Acta Crystallogr F Struct Biol Commun, 74, 2018
2X4S
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BU of 2x4s by Molmil
Crystal structure of MHC CLass I HLA-A2.1 bound to a peptide representing the epitope of the H5N1 (Avian Flu) Nucleoprotein
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-2-MICROGLOBULIN, GLYCEROL, ...
Authors:Celie, P.H.N, Toebes, M, Rodenko, B, Ovaa, H, Perrakis, A, Schumacher, T.N.M.
Deposit date:2010-02-02
Release date:2010-03-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Uv-Induced Ligand Exchange in Mhc Class I Protein Crystals
J.Am.Chem.Soc., 131, 2009
2X4O
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BU of 2x4o by Molmil
Crystal structure of MHC CLass I HLA-A2.1 bound to HIV-1 envelope peptide env120-128
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-2-MICROGLOBULIN, ENVELOPE GLYCOPROTEIN GP160, ...
Authors:Celie, P.H.N, Toebes, M, Rodenko, B, Ovaa, H, Perrakis, A, Schumacher, T.N.M.
Deposit date:2010-02-02
Release date:2010-03-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Uv-Induced Ligand Exchange in Mhc Class I Protein Crystals.
J.Am.Chem.Soc., 131, 2009
2XSE
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BU of 2xse by Molmil
The structural basis for recognition of J-base containing DNA by a novel DNA-binding domain in JBP1
Descriptor: GLYCEROL, NITRATE ION, THYMINE DIOXYGENASE JBP1
Authors:Heidebrecht, T, Christodoulou, E, Chalmers, M.J, Jan, S, ter Riete, B, Grover, R.K, Joosten, R.P, Littler, D, vanLuenen, H, Griffin, P.R, Wentworth, P, Borst, P, Perrakis, A.
Deposit date:2010-09-28
Release date:2011-03-30
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Structural Basis for Recognition of Base J Containing DNA by a Novel DNA Binding Domain in Jbp1.
Nucleic Acids Res., 39, 2011
2XRG
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BU of 2xrg by Molmil
Crystal structure of Autotaxin (ENPP2) in complex with the HA155 boronic acid inhibitor
Descriptor: CALCIUM ION, ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, IODIDE ION, ...
Authors:Hausmann, J, Albers, H.M.H.G, Perrakis, A.
Deposit date:2010-09-14
Release date:2011-01-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis of Substrate Discrimination and Integrin Binding by Autotaxin.
Nat.Struct.Mol.Biol., 18, 2011
2Y7Y
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BU of 2y7y by Molmil
APLYSIA CALIFORNICA ACHBP IN APO STATE
Descriptor: SOLUBLE ACETYLCHOLINE RECEPTOR
Authors:Ulens, C, Akdemir, A, Jongejan, A, van Elk, R, Bertrand, S, Perrakis, A, Leurs, R, Smit, A.B, Sixma, T.K, Bertrand, D, De Esch, I.J.
Deposit date:2011-02-02
Release date:2011-03-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X-Ray Analysis.
J.Med.Chem., 52, 2009

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