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3MGX
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BU of 3mgx by Molmil
Crystal Structure of P450 OxyD that is involved in the Biosynthesis of Vancomycin-type Antibiotics
Descriptor: GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, Putative P450 monooxygenase
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2010-04-07
Release date:2010-06-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural characterization of oxyd, a cytochrome p450 involved in {beta}-hydroxytyrosine formation in vancomycin biosynthesis
J.Biol.Chem., 285, 2010
3NC3
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BU of 3nc3 by Molmil
CYP134A1 structure with a closed substrate binding loop
Descriptor: Cytochrome P450 cypX, GLYCEROL, MAGNESIUM ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2010-06-04
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry, 49, 2010
3NC6
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BU of 3nc6 by Molmil
CYP134A1 1-phenylimidazole bound structure
Descriptor: 1-phenyl-1H-imidazole, Cytochrome P450 cypX, MAGNESIUM ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2010-06-04
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry, 49, 2010
3NC7
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BU of 3nc7 by Molmil
CYP134A1 2-phenylimidazole bound structure
Descriptor: 2-phenyl-1H-imidazole, Cytochrome P450 cypX, MAGNESIUM ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2010-06-04
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry, 49, 2010
3NC5
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BU of 3nc5 by Molmil
CYP134A1 structure with an open substrate binding loop
Descriptor: Cytochrome P450 cypX, GLYCEROL, MAGNESIUM ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2010-06-04
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry, 49, 2010
3O1A
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BU of 3o1a by Molmil
Structure of OxyE (CYP165D3), a Cytochrome P450 Involved in Teicoplanin Biosynthesis
Descriptor: Oxy protein, PROTOPORPHYRIN IX CONTAINING FE
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2010-07-21
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural characterization of CYP165D3, a cytochrome P450 involved in phenolic coupling in teicoplanin biosynthesis.
Arch.Biochem.Biophys., 507, 2011
3EJE
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BU of 3eje by Molmil
Crystal Structure of P450BioI in complex with octadec-9Z-enoic acid ligated Acyl Carrier Protein
Descriptor: Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2008-09-18
Release date:2008-10-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EJD
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BU of 3ejd by Molmil
Crystal Structure of P450BioI in complex with hexadec-9Z-enoic acid ligated Acyl Carrier Protein
Descriptor: Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme, CHLORIDE ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2008-09-18
Release date:2008-10-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EJB
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BU of 3ejb by Molmil
Crystal Structure of P450BioI in complex with tetradecanoic acid ligated Acyl Carrier Protein
Descriptor: Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme, CHLORIDE ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2008-09-18
Release date:2008-10-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
4L0F
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BU of 4l0f by Molmil
Structure of P450sky (CYP163B3), a cytochrome P450 from skyllamycin biosynthesis (open active site)
Descriptor: 1,2-ETHANEDIOL, P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Cryle, M.J.
Deposit date:2013-05-31
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cytochrome p450sky interacts directly with the nonribosomal Peptide synthetase to generate three amino Acid precursors in skyllamycin biosynthesis.
Acs Chem.Biol., 8, 2013
4L0E
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BU of 4l0e by Molmil
Structure of P450sky (CYP163B3), a cytochrome P450 from skyllamycin biosynthesis (heme-coordinated expression tag)
Descriptor: P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Cryle, M.J.
Deposit date:2013-05-31
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cytochrome p450sky interacts directly with the nonribosomal Peptide synthetase to generate three amino Acid precursors in skyllamycin biosynthesis.
Acs Chem.Biol., 8, 2013
5EX9
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BU of 5ex9 by Molmil
Structure of P450 StaF from glycopeptide antibiotic A47934 biosynthesis; glycerol cryo
Descriptor: Cytochrome P450, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE
Authors:Cryle, M.J, Ulrich, V.
Deposit date:2015-11-23
Release date:2017-01-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934.
Beilstein J Org Chem, 12, 2016
5EX8
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BU of 5ex8 by Molmil
Structure of P450 StaF from glycopeptide antibiotic A47934 biosynthesis; ethylene glycol cryo
Descriptor: 1,2-ETHANEDIOL, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
Authors:Cryle, M.J, Ulrich, V.
Deposit date:2015-11-23
Release date:2017-01-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934.
Beilstein J Org Chem, 12, 2016
5EX6
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BU of 5ex6 by Molmil
Structure of P450 StaH from glycopeptide antibiotic A47934 biosynthesis
Descriptor: 1,2-ETHANEDIOL, Cytochrome P450, GLYCEROL, ...
Authors:Cryle, M.J, Ulrich, V.
Deposit date:2015-11-23
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH.
Mol Biosyst, 12, 2016
6FSH
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BU of 6fsh by Molmil
Crystal structure of hybrid P450 OxyBtei(BC/FGvan)
Descriptor: ACETATE ION, OxyB protein, POTASSIUM ION, ...
Authors:Brieke, C, Tarnawski, M, Greule, A, Cryle, M.J.
Deposit date:2018-02-19
Release date:2018-05-23
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach.
J. Inorg. Biochem., 185, 2018
8U3N
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BU of 8u3n by Molmil
Structure of P450Blt from Micromonospora sp. MW-13
Descriptor: Cytochrome P450-SU1, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Hansen, M.H, Cryle, M.J, Zhao, Y.
Deposit date:2023-09-08
Release date:2024-01-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis
Acs Catalysis, 2024
8UKZ
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BU of 8ukz by Molmil
Structure of P450Blt from Micromonospora sp. MW-13 with E238A Mutation
Descriptor: ACETATE ION, Cytochrome P450-SU1, DI(HYDROXYETHYL)ETHER, ...
Authors:Hansen, M.H, Cryle, M.J.
Deposit date:2023-10-15
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis
Acs Catalysis, 2024
8U2M
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BU of 8u2m by Molmil
Structure of P450Blt from Micromonospora sp. MW-13 in Complex with Biarylitide
Descriptor: 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, ACETATE ION, Cytochrome P450-SU1, ...
Authors:Hansen, M.H, Cryle, M.J.
Deposit date:2023-09-06
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis
Acs Catalysis, 2024
7TTP
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BU of 7ttp by Molmil
P450 (OxyA) from kistamicin biosynthesis, mixed heme conformation
Descriptor: GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, cytochrome P450 hydroxylase
Authors:Greule, A, Izore, T, Cryle, M.J.
Deposit date:2022-02-01
Release date:2022-05-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage.
Front Chem, 10, 2022
7TTA
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BU of 7tta by Molmil
P450 (OxyA) from kistamicin biosynthesis, mixed heme conformation, attenuated beam
Descriptor: GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450 hydroxylase
Authors:Greule, A, Izore, T, Cryle, M.J.
Deposit date:2022-02-01
Release date:2022-05-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage.
Front Chem, 10, 2022
7TTQ
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BU of 7ttq by Molmil
P450 (OxyA) from kistamicin biosynthesis, imidazole complex
Descriptor: GLYCEROL, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Greule, A, Izore, T, Cryle, M.J.
Deposit date:2022-02-01
Release date:2022-05-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage.
Front Chem, 10, 2022
7TTO
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BU of 7tto by Molmil
P450 (OxyA) from kistamicin biosynthesis, mixed heme conformation
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, cytochrome P450 hydroxylase
Authors:Greule, A, Izore, T, Cryle, M.J.
Deposit date:2022-02-01
Release date:2022-05-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage.
Front Chem, 10, 2022
7TTB
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BU of 7ttb by Molmil
P450 (OxyA) from kistamicin biosynthesis, Y99F mutant
Descriptor: GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450 hydroxylase
Authors:Greule, A, Izore, T, Cryle, M.J.
Deposit date:2022-02-01
Release date:2022-05-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.801592 Å)
Cite:The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage.
Front Chem, 10, 2022
8GJP
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BU of 8gjp by Molmil
A1 Int graft: Adenylation domain 1 core construct from teicoplanin biosynthesis, intermediate selection pocket graft
Descriptor: MbtH-like short polypeptide, Non-ribosomal peptide synthetase
Authors:Hansen, M.H, Cryle, M.J.
Deposit date:2023-03-16
Release date:2023-12-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides.
Nat Commun, 14, 2023
8GJ4
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BU of 8gj4 by Molmil
A1 Tei: Adenylation domain 1 core construct from teicoplanin biosynthesis
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, MbtH-like short polypeptide, ...
Authors:Hansen, M.H, Cryle, M.J.
Deposit date:2023-03-14
Release date:2023-12-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides.
Nat Commun, 14, 2023

 

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