7CYL
 
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7CUN
 | | The structure of human Integrator-PP2A complex | | Descriptor: | Integrator complex subunit 1, Integrator complex subunit 11, Integrator complex subunit 2, ... | | Authors: | Zheng, H, Qi, Y, Liu, W, Li, J, Wang, J, Xu, Y. | | Deposit date: | 2020-08-23 | | Release date: | 2020-11-25 | | Last modified: | 2020-12-09 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Science, 370, 2020
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6XU2
 | | Human karyopherin RanBP5 (isoform-3) | | Descriptor: | Antipain, Importin-5, NICKEL (II) ION | | Authors: | Swale, C, McCarthy, A.A, Berger, I, Bieniossek, C, Delmas, B, Ruigrok, R.W.H, Crepin, T. | | Deposit date: | 2020-01-17 | | Release date: | 2020-04-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.834 Å) | | Cite: | X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
J.Mol.Biol., 432, 2020
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6XTE
 | | Human karyopherin RanBP5 (isoform-1) | | Descriptor: | Antipain, CHLORIDE ION, Importin-5, ... | | Authors: | Swale, C, McCarthy, A.A, Ruigrok, R.W.H, Crepin, T. | | Deposit date: | 2020-01-16 | | Release date: | 2020-04-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
J.Mol.Biol., 432, 2020
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6U62
 | | Raptor-Rag-Ragulator complex | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Rogala, K.B, Sabatini, D.M. | | Deposit date: | 2019-08-29 | | Release date: | 2019-10-30 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Structural basis for the docking of mTORC1 on the lysosomal surface.
Science, 366, 2019
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6SB2
 | | cryo-EM structure of mTORC1 bound to active RagA/C GTPases | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ... | | Authors: | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | | Deposit date: | 2019-07-18 | | Release date: | 2019-10-16 | | Last modified: | 2019-10-23 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
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6SB0
 | | cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... | | Authors: | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | | Deposit date: | 2019-07-18 | | Release date: | 2019-10-16 | | Last modified: | 2019-10-23 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
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6NTS
 | | Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP) | | Descriptor: | MANGANESE (II) ION, N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)benzene-1-sulfonamide, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, ... | | Authors: | Huang, W, Taylor, D. | | Deposit date: | 2019-01-30 | | Release date: | 2020-05-06 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.63 Å) | | Cite: | Selective PP2A Enhancement through Biased Heterotrimer Stabilization.
Cell, 181, 2020
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6MQ5
 | | Structure of human CLASP1 TOG1 | | Descriptor: | CLIP-associating protein 1 | | Authors: | Leano, J.B, Slep, K.C. | | Deposit date: | 2018-10-09 | | Release date: | 2019-07-17 | | Last modified: | 2020-01-01 | | Method: | X-RAY DIFFRACTION (2.146 Å) | | Cite: | Structures of TOG1 and TOG2 from the human microtubule dynamics regulator CLASP1.
Plos One, 14, 2019
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6IUR
 | | A phosphatase complex STRN3-PP2Aa | | Descriptor: | PP2A scaffolding subunit, PROPANE, Striatin-3 | | Authors: | Tang, Y, Zhou, Z.C. | | Deposit date: | 2018-11-30 | | Release date: | 2019-12-04 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.33 Å) | | Cite: | Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer.
Cancer Cell, 38, 2020
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6EF4
 | | Crystal structure of mouse PP2A Aalpha P179R mutant | | Descriptor: | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | | Authors: | Wang, Z, Shen, G, Xu, W. | | Deposit date: | 2018-08-16 | | Release date: | 2019-06-26 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | The Highly Recurrent PP2A A alpha-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis.
Cancer Res., 79, 2019
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6BCX
 | | mTORC1 structure refined to 3.0 angstroms | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, ... | | Authors: | Pavletich, N.P, Yang, H. | | Deposit date: | 2017-10-20 | | Release date: | 2017-12-20 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
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6BCU
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5YVI
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5YVH
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5YVG
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5W0W
 | | Crystal structure of Protein Phosphatase 2A bound to TIPRL | | Descriptor: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... | | Authors: | Wu, C, Zheng, A, Li, J, Satyshur, K, Xing, Y. | | Deposit date: | 2017-06-01 | | Release date: | 2018-01-17 | | Last modified: | 2020-01-01 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Methylation-regulated decommissioning of multimeric PP2A complexes.
Nat Commun, 8, 2017
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5W0V
 | | Crystal structure of full-length Kluyveromyces lactis Kap123 with histone H4 1-34 | | Descriptor: | Histone H4 1-34, Kap123 | | Authors: | An, S, Yoon, J, Song, J.-J, Cho, U.-S. | | Deposit date: | 2017-05-31 | | Release date: | 2017-11-01 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.821 Å) | | Cite: | Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123.
Elife, 6, 2017
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5VE8
 | | Crystal structure of full-length Kluyveromyces lactis Kap123 with histone H3 1-28 | | Descriptor: | Histone H3, Kap123 | | Authors: | An, S, Yoon, J, Song, J.-J, Cho, U.-S. | | Deposit date: | 2017-04-04 | | Release date: | 2017-11-01 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123.
Elife, 6, 2017
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5VCH
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5TQC
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5OWU
 | | Kap95:Nup1 complex | | Descriptor: | Importin subunit beta-1, Nucleoporin NUP1 | | Authors: | Stewart, M. | | Deposit date: | 2017-09-04 | | Release date: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for the high-affinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95p.
J. Mol. Biol., 349, 2005
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5J3V
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5H64
 | | Cryo-EM structure of mTORC1 | | Descriptor: | Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 | | Authors: | Yang, H, Wang, J, Liu, M, Chen, X, Huang, M, Tan, D, Dong, M, Wong, C.C.L, Wang, J, Xu, Y, Wang, H. | | Deposit date: | 2016-11-10 | | Release date: | 2017-01-25 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | 4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1
Protein Cell, 7, 2016
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4OO6
 | | Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1) | | Descriptor: | RNA-binding protein 39, Transportin-1 | | Authors: | Sampathkumar, P, Brower, A, Soniat, M, Bonanno, J, Hillerich, B, Seidel, R.D, Rout, M.P, Chook, Y.M, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals) | | Deposit date: | 2014-01-30 | | Release date: | 2014-02-12 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1)
to be published
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