7Q4A
| Toxoplasma gondii PRP4K kinase domain (L715F) bound to altiratinib | Descriptor: | Altiratinib, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Swale, C, Bellini, V, Bowler, M. | Deposit date: | 2021-10-29 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase. Sci Transl Med, 14, 2022
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6XU2
| Human karyopherin RanBP5 (isoform-3) | Descriptor: | Antipain, Importin-5, NICKEL (II) ION | Authors: | Swale, C, McCarthy, A.A, Berger, I, Bieniossek, C, Delmas, B, Ruigrok, R.W.H, Crepin, T. | Deposit date: | 2020-01-17 | Release date: | 2020-04-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.834 Å) | Cite: | X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking. J.Mol.Biol., 432, 2020
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6XTE
| Human karyopherin RanBP5 (isoform-1) | Descriptor: | Antipain, CHLORIDE ION, Importin-5, ... | Authors: | Swale, C, McCarthy, A.A, Ruigrok, R.W.H, Crepin, T. | Deposit date: | 2020-01-16 | Release date: | 2020-04-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking. J.Mol.Biol., 432, 2020
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7NG2
| Crystal structure of Toxoplasma CPSF4-YTH domain in apo form | Descriptor: | ISOPROPYL ALCOHOL, Zinc finger (CCCH type) motif-containing protein | Authors: | Swale, C, Bowler, M.W. | Deposit date: | 2021-02-08 | Release date: | 2021-07-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma . Elife, 10, 2021
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7NJC
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7NH2
| Crystal structure of Toxoplasma CPSF4-YTH domain bound to m6A | Descriptor: | TETRAETHYLENE GLYCOL, Zinc finger (CCCH type) motif-containing protein, ~{N},9-dimethylpurin-6-amine | Authors: | Swale, C, Bowler, M.W. | Deposit date: | 2021-02-09 | Release date: | 2021-07-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma . Elife, 10, 2021
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6Q5A
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6Q55
| Crystal structure of Cryptosporidium hominis CPSF3 in complex with Compound 61 | Descriptor: | 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-5-yl]propanoic acid, Cleavage and Polyadenylation Specificity Factor 3 (CPSF3), GLYCEROL, ... | Authors: | Palencia, A, Swale, C. | Deposit date: | 2018-12-07 | Release date: | 2019-11-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection. Sci Transl Med, 11, 2019
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