7CYL

Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)

Summary for 7CYL

• Entry DOI: 10.2210/pdb7cyl/pdb
• Descriptor: Transportin-1, RNA-binding protein FUS (2 entities in total)
• Functional Keywords: nuclear import, karyopherin, transport protein, transport protein-rna binding protein complex, transport protein/rna binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 104113.59

Authors

Yoshizawa, T.,Chook, Y.M. (deposition date: 2020-09-03, release date: 2021-02-24, Last modification date: 2023-11-29)

• Primary citation: Gonzalez, A.,Mannen, T.,Cagatay, T.,Fujiwara, A.,Matsumura, H.,Niesman, A.B.,Brautigam, C.A.,Chook, Y.M.,Yoshizawa, T.; Mechanism of karyopherin-beta 2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X).; Sci Rep, 11:3754-3754, 2021; PubMed: 33580145; DOI: 10.1038/s41598-021-83196-y

Experimental method

X-RAY DIFFRACTION (2.7 Å)