6EF4
Crystal structure of mouse PP2A Aalpha P179R mutant
Summary for 6EF4
Entry DOI | 10.2210/pdb6ef4/pdb |
Descriptor | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (1 entity in total) |
Functional Keywords | pp2a, aalpha, protein binding |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 65509.50 |
Authors | |
Primary citation | Taylor, S.E.,O'Connor, C.M.,Wang, Z.,Shen, G.,Song, H.,Leonard, D.,Sangodkar, J.,LaVasseur, C.,Avril, S.,Waggoner, S.,Zanotti, K.,Armstrong, A.J.,Nagel, C.,Resnick, K.,Singh, S.,Jackson, M.W.,Xu, W.,Haider, S.,DiFeo, A.,Narla, G. The Highly Recurrent PP2A A alpha-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis. Cancer Res., 79:4242-4257, 2019 Cited by PubMed: 31142515DOI: 10.1158/0008-5472.CAN-19-0218 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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