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3LPG	Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 3-(2-fluorophenyl)-1-(2-hydroxyethyl)-1-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea Descriptor: 3-(2-fluorophenyl)-1-(2-hydroxyethyl)-1-[(6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]urea, Beta-glucuronidase Authors: Wallace, B.D, Redinbo, M.R. Deposit date: 2010-02-05 Release date: 2010-11-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.425 Å) Cite: Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science, 330, 2010
3MV1	E.Coli (lacZ) beta-galactosidase (R599A) in complex with Guanidinium Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, GUANIDINE, ... Authors: Dugdale, M.L, Vance, M, Driedger, M.L, Nibber, A, Tran, A, Huber, R.E. Deposit date: 2010-05-03 Release date: 2011-03-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Importance of Arg-599 of b-galactosidase (Escherichia coli) as an anchor for the open conformations of Phe-601 and the active-site loop Biochem.Cell Biol., 88, 2010
3MUZ	E.Coli (lacZ) beta-galactosidase (R599A) in complex with IPTG Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ... Authors: Dugdale, M.L, Vance, M.L, Driedger, M.R, Nibber, A, Tran, A, Huber, R.E. Deposit date: 2010-05-03 Release date: 2011-03-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Importance of Arg-599 of b-galactosidase (Escherichia coli) as an anchor for the open conformations of Phe-601 and the active-site loop Biochem.Cell Biol., 88, 2010
3MUY	E. coli (lacZ) beta-galactosidase (R599A) Descriptor: Beta-D-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: Dugdale, M.L, Vance, M, Driedger, M.L, Nibber, A, Tran, A, Huber, R.E. Deposit date: 2010-05-03 Release date: 2011-03-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Importance of Arg-599 of beta-galactosidase (Escherichia coli) as an anchor for the open conformations of Phe-601 and the active-site loop Biochem.Cell Biol., 88, 2010
3MV0	E. COLI (lacZ) BETA-GALACTOSIDASE (R599A) IN COMPLEX WITH D-GALCTOPYRANOSYL-1-ONE Descriptor: Beta-galactosidase, D-galactonolactone, DIMETHYL SULFOXIDE, ... Authors: Dugdale, M.L, Vance, M, Driedger, M.L, Nibber, A, Tran, A, Huber, R.E. Deposit date: 2010-05-03 Release date: 2011-03-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Importance of Arg-599 of b-galactosidase (Escherichia coli) as an anchor for the open conformations of Phe-601 and the active-site loop Biochem.Cell Biol., 88, 2010
3OB8	Structure of the beta-galactosidase from Kluyveromyces lactis in complex with galactose Descriptor: Beta-galactosidase, MAGNESIUM ION, MANGANESE (II) ION, ... Authors: Fernandez-Leiro, R, Pereira-Rodriguez, A, Becerra, M, Gonzalez-Siso, I, Cerdan, M.E, Sanz-Aparicio, J. Deposit date: 2010-08-06 Release date: 2011-08-17 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis of specificity in tetrameric Kluyveromyces lactis beta-galactosidase. J.Struct.Biol., 177, 2012
3OBA	Structure of the beta-galactosidase from Kluyveromyces lactis Descriptor: Beta-galactosidase, GLYCEROL, MANGANESE (III) ION Authors: Fernandez-Leiro, R, Pereira-Rodriguez, A, Becerra, M, Gonzalez-Siso, I, Cerdan, M.E, Sanz-Aparicio, J. Deposit date: 2010-08-06 Release date: 2011-08-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structural basis of specificity in tetrameric Kluyveromyces lactis beta-galactosidase. J.Struct.Biol., 177, 2012
3SEP	E. coli (lacZ) beta-galactosidase (S796A) Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E. Deposit date: 2011-06-10 Release date: 2012-01-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517, 2012
3T0B	E. coli (LacZ) beta-galactosidase (S796T) IPTG complex Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ... Authors: Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E. Deposit date: 2011-07-19 Release date: 2012-01-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: er-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517, 2012
3T0A	E. coli (LacZ) beta-galactosidase (S796T) Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E. Deposit date: 2011-07-19 Release date: 2012-01-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517, 2012
3T09	E. coli (LacZ) beta-galactosidase (S796A) galactonolactone complex Descriptor: Beta-galactosidase, D-galactonolactone, DIMETHYL SULFOXIDE, ... Authors: Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E. Deposit date: 2011-07-19 Release date: 2012-01-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517, 2012
3T08	E. coli (LacZ) beta-galactosidase (S796A) IPTG complex Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ... Authors: Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E. Deposit date: 2011-07-19 Release date: 2012-01-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517, 2012
3T0D	E.coli (lacZ) beta-galactosidase (S796T) in complex with galactonolactone Descriptor: Beta-galactosidase, D-galactonolactone, DIMETHYL SULFOXIDE, ... Authors: Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E. Deposit date: 2011-07-20 Release date: 2012-01-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Ser-796 of Beta-galactosidase (E. coli) plays a Key role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517, 2012
3T2O	E. coli (lacZ) beta-galactosidase (S796D) Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E. Deposit date: 2011-07-22 Release date: 2012-01-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517, 2012
3T2Q	E. coli (lacZ) beta-galactosidase (S796D) in complex with galactonolactone Descriptor: Beta-galactosidase, D-galactonolactone, DIMETHYL SULFOXIDE, ... Authors: Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E. Deposit date: 2011-07-22 Release date: 2012-01-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517, 2012
3T2P	E. coli (lacZ) beta-galactosidase (S796D) in complex with IPTG Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ... Authors: Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E. Deposit date: 2011-07-22 Release date: 2012-01-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517, 2012
3VD9	E. coli (lacZ) beta-galactosidase (N460S) in complex with IPTG Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ... Authors: Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E. Deposit date: 2012-01-04 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability. Arch.Biochem.Biophys., 521, 2012
3VDC	E. coli (lacZ) beta-galactosidase (N460T) in complex with IPTG Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ... Authors: Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E. Deposit date: 2012-01-04 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability. Arch.Biochem.Biophys., 521, 2012
3VD3	E. coli (lacZ) beta-galactosidase (N460D) Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E. Deposit date: 2012-01-04 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability. Arch.Biochem.Biophys., 521, 2012
3VD7	E. coli (lacZ) beta-galactosidase (N460S) in complex with galactotetrazole Descriptor: (5R, 6S, 7S, ... Authors: Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E. Deposit date: 2012-01-04 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.87 Å) Cite: Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability. Arch.Biochem.Biophys., 521, 2012
3VDB	E. coli (lacZ) beta-galactosidase (N460T) in complex with galactonolactone Descriptor: Beta-galactosidase, D-galactonolactone, DIMETHYL SULFOXIDE, ... Authors: Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E. Deposit date: 2012-01-04 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability. Arch.Biochem.Biophys., 521, 2012
3VDA	E. coli (lacZ) beta-galactosidase (N460T) Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E. Deposit date: 2012-01-04 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability. Arch.Biochem.Biophys., 521, 2012
3VD5	E. coli (lacZ) beta-galactosidase (N460S) Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E. Deposit date: 2012-01-04 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability. Arch.Biochem.Biophys., 521, 2012
3VD4	E. coli (lacZ) beta-galactosidase (N460D) in complex with IPTG Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ... Authors: Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E. Deposit date: 2012-01-04 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability. Arch.Biochem.Biophys., 521, 2012
4DUW	E. coli (lacZ) beta-galactosidase (G974A) in complex with allolactose Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: Wheatley, R.W, Lo, S, Janzcewicz, L.J, Dugdale, M.L, Huber, R.E. Deposit date: 2012-02-22 Release date: 2013-03-20 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Explanation for Allolactose (lac operon inducer) Synthesis by lacZ beta-Galactosidase and the Evolutionary Relationship between Allolactose synthesis and the lac Repressor J.Biol.Chem., 288, 2013

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