3T2P

E. coli (lacZ) beta-galactosidase (S796D) in complex with IPTG

Summary for 3T2P

Entry DOI	10.2210/pdb3t2p/pdb
Related	1DP0 3SEP 3T08 3T09 3T0A 3T0B 3T0D 3T2O 3T2Q
Descriptor	Beta-galactosidase, 1-methylethyl 1-thio-beta-D-galactopyranoside, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	dynamic loop conformation, ser-796, tim barrel (alpha/beta barrel), jelly-roll barrel, immunoglobulin, beta supersandwich, glycosidase, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	4
Total formula weight	485386.96
Authors	Jancewicz, L.J.,Wheatley, R.W.,Sutendra, G.,Lee, M.,Fraser, M.,Huber, R.E. (deposition date: 2011-07-22, release date: 2012-01-18, Last modification date: 2024-02-28)
Primary citation	Jancewicz, L.J.,Wheatley, R.W.,Sutendra, G.,Lee, M.,Fraser, M.E.,Huber, R.E. Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517:111-122, 2012 Cited by PubMed: 22155115 DOI: 10.1016/j.abb.2011.11.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation