PDB: 155 件ウェブページステータス検索Chemie searchBIRD

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8F10	Structure of the MDM2 P53 binding domain in complex with H102, an all-D Helicon Polypeptide 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... 著者 Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. 登録日 2022-11-04 公開日 2023-02-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
8F13	Structure of the MDM2 P53 binding domain in complex with H103, an all-D Helicon Polypeptide, alternative C-terminus 分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, E3 ubiquitin-protein ligase Mdm2, ... 著者 Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. 登録日 2022-11-04 公開日 2023-02-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
8F12	Structure of the MDM2 P53 binding domain in complex with H103, an all-D Helicon Polypeptide 分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, H103, ... 著者 Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. 登録日 2022-11-04 公開日 2023-02-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
8F0Z	Structure of the MDM2 P53 binding domain in complex with H101, an all-D Helicon Polypeptide 分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, H101, ... 著者 Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. 登録日 2022-11-04 公開日 2023-02-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
8GJS	Stapled Peptide ALRN-6924 Bound to MDMX 分子名称: ACE-LEU-THR-PHE-ALA-GLU-TYR-TRP-ALA-GLN-LEU-DAL-ALA-ALA-ALA-ALA-ALA-DAL, Protein Mdm4 著者 Graves, B.J, Janson, C, Lukacs, C. 登録日 2023-03-16 公開日 2023-07-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized alpha-Helical Peptide in Clinical Development. J.Med.Chem., 66, 2023
4MDN	Structure of a novel submicromolar MDM2 inhibitor 分子名称: 3-{(1S)-2-(tert-butylamino)-1-[{4-[(4-chlorobenzyl)oxy]benzyl}(formyl)amino]-2-oxoethyl}-6-chloro-1H-indole-2-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Bista, M, Popowicz, G, Holak, T.A. 登録日 2013-08-23 公開日 2013-11-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.905 Å) 主引用文献 Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction. Structure, 21, 2013
4LWV	The 2.3A Crystal Structure of Humanized Xenopus MDM2 with RO5545353 分子名称: (2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Graves, B.J, Lukacs, C, Janson, C.A. 登録日 2013-07-28 公開日 2014-07-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development. ACS MED.CHEM.LETT., 5, 2014
4LWT	The 1.6A Crystal Structure of Humanized Xenopus MDM2 with RO5027344 分子名称: (3S)-3-[(3R)-1-acetylpiperidin-3-yl]-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-2H-indol-2-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Graves, B.J, Lukacs, C, Kammlott, U. 登録日 2013-07-28 公開日 2014-07-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg.Med.Chem., 22, 2014
4MDQ	Structure of a novel submicromolar MDM2 inhibitor 分子名称: 3-[(1R)-2-(benzylamino)-1-{[(2S)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl]amino}-2-oxoethyl]-6-chloro-N-hydroxy-1H-indole-2-carboxamide, E3 ubiquitin-protein ligase Mdm2 著者 Bista, M, Popowicz, G, Holak, T.A. 登録日 2013-08-23 公開日 2013-11-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.119 Å) 主引用文献 Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction. Structure, 21, 2013
4LWU	The 1.14A Crystal Structure of Humanized Xenopus MDM2 with RO5499252 分子名称: (2'S,3R,4'S,5'R)-N-(4-carbamoylphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Graves, B.J, Lukacs, C, Janson, C.A. 登録日 2013-07-28 公開日 2014-07-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.14 Å) 主引用文献 Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg.Med.Chem., 22, 2014
4N5T	The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041 分子名称: ATSP-7041 stapled-peptide, Protein Mdm4 著者 Graves, B.J, Lukacs, C, Janson, C.A. 登録日 2013-10-10 公開日 2013-11-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy. Proc.Natl.Acad.Sci.USA, 110, 2013
4OAS	co-crystal structure of MDM2 (17-111) in complex with compound 25 分子名称: E3 ubiquitin-protein ligase Mdm2, SULFATE ION, [(3R,5R,6S)-1-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acid 著者 Huang, X. 登録日 2014-01-06 公開日 2014-02-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2-p53 Inhibitor in Clinical Development. J.Med.Chem., 57, 2014
4ODE	Co-Crystal Structure of MDM2 with Inhibitor Compound 4 分子名称: (2-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}-1,3-thiazol-5-yl)acetic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. 登録日 2014-01-10 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
4OGV	Co-Crystal Structure of MDM2 with Inhibitor Compound 49 分子名称: E3 ubiquitin-protein ligase Mdm2, [(2S,5R,6R)-4-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid 著者 Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. 登録日 2014-01-16 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.197 Å) 主引用文献 Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
4OGN	Co-Crystal Structure of MDM2 with Inhbitor Compound 3 分子名称: 6-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. 登録日 2014-01-16 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.377 Å) 主引用文献 Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
4OGT	Co-Crystal Structure of MDM2 with Inhbitor Compound 46 分子名称: 6-{[(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. 登録日 2014-01-16 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5361 Å) 主引用文献 Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
4OBA	Co-crystal structure of MDM2 with Inhibitor Compound 4 分子名称: E3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid 著者 Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. 登録日 2014-01-07 公開日 2014-03-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.602 Å) 主引用文献 Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 57, 2014
4OCC	co-crystal structure of MDM2(17-111) in complex with compound 48 分子名称: E3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid 著者 Huang, X. 登録日 2014-01-08 公開日 2014-04-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
4OQ3	Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction 分子名称: 1-(5-chloro-2-methylphenyl)-5-(3-chlorophenyl)-2-(3-methylphenyl)-1H-imidazole-4-carboxylic acid, E3 ubiquitin-protein ligase Mdm2 著者 Kallen, J. 登録日 2014-02-07 公開日 2014-04-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction. Bioorg.Med.Chem.Lett., 24, 2014
4ODF	Co-Crystal Structure of MDM2 with Inhibitor Compound 47 分子名称: 6-{[(2S,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2 著者 Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. 登録日 2014-01-10 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2006 Å) 主引用文献 Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
4ERE	crystal structure of MDM2 (17-111) in complex with compound 23 分子名称: E3 ubiquitin-protein ligase Mdm2, SULFATE ION, [(3R,5R,6S)-1-[(2S)-1-tert-butoxy-1-oxobutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl]acetic acid 著者 Huang, X. 登録日 2012-04-20 公開日 2012-05-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based design of novel inhibitors of the MDM2-p53 interaction. J.Med.Chem., 55, 2012
4HG7	Crystal Structure of an MDM2/Nutlin-3a complex 分子名称: 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Noble, M.E.M, Anil, B, Riedinger, C, Endicott, J.A. 登録日 2012-10-07 公開日 2013-07-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant. Acta Crystallogr.,Sect.D, 69, 2013
4HBM	Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors 分子名称: E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-2-oxopiperidin-3-yl}acetic acid 著者 Huang, X. 登録日 2012-09-28 公開日 2012-10-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Ordering of the N-terminus of human MDM2 by small molecule inhibitors. J.Am.Chem.Soc., 134, 2012
4IPF	The 1.7A crystal structure of humanized Xenopus MDM2 with RO5045337 分子名称: E3 ubiquitin-protein ligase Mdm2, SULFATE ION, [(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone 著者 Graves, B.J, Lukacs, C, Kammlott, R.U, Crowther, R. 登録日 2013-01-09 公開日 2013-02-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models. Cancer Res., 73, 2013
4J3E	The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a 分子名称: 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Graves, B.J, Lukacs, C.M, Kammlott, R.U, Crowther, R. 登録日 2013-02-05 公開日 2013-04-24 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development. ACS Med Chem Lett, 4, 2013

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