4N5T

The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041

Summary for 4N5T

Entry DOI	10.2210/pdb4n5t/pdb
Related PRD ID	PRD_001189
Descriptor	Protein Mdm4, ATSP-7041 stapled-peptide (3 entities in total)
Functional Keywords	mdm4, p53, apoptosis, cell cycle, p53 antagonist, nucleus, cell cycle-cell cycle inhibitor complex, cell cycle/cell cycle inhibitor
Biological source	Danio rerio (leopard danio, zebra danio, zebra fish) More
Cellular location	Nucleus : Q7ZUW7
Total number of polymer chains	2
Total formula weight	12056.12
Authors	Graves, B.J.,Lukacs, C.,Janson, C.A. (deposition date: 2013-10-10, release date: 2013-11-20, Last modification date: 2023-11-15)
Primary citation	Chang, Y.S.,Graves, B.,Guerlavais, V.,Tovar, C.,Packman, K.,To, K.H.,Olson, K.A.,Kesavan, K.,Gangurde, P.,Mukherjee, A.,Baker, T.,Darlak, K.,Elkin, C.,Filipovic, Z.,Qureshi, F.Z.,Cai, H.,Berry, P.,Feyfant, E.,Shi, X.E.,Horstick, J.,Annis, D.A.,Manning, A.M.,Fotouhi, N.,Nash, H.,Vassilev, L.T.,Sawyer, T.K. Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy. Proc.Natl.Acad.Sci.USA, 110:E3445-E3454, 2013 Cited by PubMed: 23946421 DOI: 10.1073/pnas.1303002110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation