4IPF

The 1.7A crystal structure of humanized Xenopus MDM2 with RO5045337

Summary for 4IPF

• Entry DOI: 10.2210/pdb4ipf/pdb
• Related: 1RV1
• Descriptor: E3 ubiquitin-protein ligase Mdm2, [(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone, SULFATE ION, ... (4 entities in total)
• Functional Keywords: mdm2, p53, protein-protein interaction, imidazoline, e3 ubiquitin ligase, nucleus, ligase-antagonist complex, ligase/antagonist
• Biological source: Xenopus laevis (clawed frog,common platanna,platanna)
• Cellular location: Nucleus, nucleoplasm (By similarity): P56273
• Total number of polymer chains: 1
• Total formula weight: 10751.33

Authors

Graves, B.J.,Lukacs, C.,Kammlott, R.U.,Crowther, R. (deposition date: 2013-01-09, release date: 2013-02-20, Last modification date: 2024-02-28)

• Primary citation: Tovar, C.,Graves, B.,Packman, K.,Filipovic, Z.,Xia, B.H.,Tardell, C.,Garrido, R.,Lee, E.,Kolinsky, K.,To, K.H.,Linn, M.,Podlaski, F.,Wovkulich, P.,Vu, B.,Vassilev, L.T.; MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models.; Cancer Res., 73:2587-2597, 2013; PubMed: 23400593; DOI: 10.1158/0008-5472.CAN-12-2807

Experimental method

X-RAY DIFFRACTION (1.7 Å)