1OHU
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7Y99
| Crystal Structure Analysis of cp2 bound BCLxl | 分子名称: | Bcl-2-like protein 1, CP2 peptide, N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide | 著者 | Li, F.W, Liu, C, Wu, C.L, Wu, D.L. | 登録日 | 2022-06-24 | 公開日 | 2023-09-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
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7YAA
| Crystal structure analysis of cp3 bound BCLxl | 分子名称: | Bcl-2-like protein 1, GLYCEROL, N-(2-acetamidoethyl)-4-(4-methanoyl-1,3-thiazol-2-yl)benzamide, ... | 著者 | Li, F.W, Liu, C, Wu, C.L, Wu, D.L. | 登録日 | 2022-06-27 | 公開日 | 2023-11-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
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7Y90
| Crystal Structure Analysis of cp1 bound BCL2 | 分子名称: | (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Apoptosis regulator Bcl-2, cp1 peptide | 著者 | Li, F.W. | 登録日 | 2022-06-24 | 公開日 | 2023-11-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
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7Y8D
| Crystal structure of cp1 bound BCLxl | 分子名称: | (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Bcl-2-like protein 1, cp1 peptide | 著者 | Li, F.W, Liu, C, Wu, C.L, Wu, D.L. | 登録日 | 2022-06-23 | 公開日 | 2023-11-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
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7YA5
| Crystal structure analysis of cp1 bound BCL2/G101V | 分子名称: | (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Apoptosis regulator Bcl-2, cp1 peptide | 著者 | Li, F.W, Liu, C, Wu, C.L, Wu, D.L. | 登録日 | 2022-06-27 | 公開日 | 2023-11-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
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7YB7
| anti-apoptotic protein BCL-2-M12 | 分子名称: | Apoptosis regulator Bcl-2,Bcl-2-like protein 1, N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide, cp2 peptide | 著者 | Li, F.W, Liu, C, Wu, D.L. | 登録日 | 2022-06-29 | 公開日 | 2023-11-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
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1TY4
| Crystal structure of a CED-9/EGL-1 complex | 分子名称: | Apoptosis regulator ced-9, EGg Laying defective EGL-1, programmed cell death activator | 著者 | Yan, N, Gu, L, Kokel, D, Xue, D, Shi, Y. | 登録日 | 2004-07-07 | 公開日 | 2004-09-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4 Mol.Cell, 15, 2004
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1PQ1
| Crystal structure of Bcl-xl/Bim | 分子名称: | Apoptosis regulator Bcl-X, BCL2-like protein 11 | 著者 | Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W. | 登録日 | 2003-06-17 | 公開日 | 2003-09-23 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function Immunity, 19, 2003
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1O0L
| THE STRUCTURE OF BCL-W REVEALS A ROLE FOR THE C-TERMINAL RESIDUES IN MODULATING BIOLOGICAL ACTIVITY | 分子名称: | Apoptosis regulator Bcl-W | 著者 | Hinds, M.G, Lackmann, M, Skea, G.L, Harrison, P.J, Huang, D.C.S, Day, C.L. | 登録日 | 2003-02-22 | 公開日 | 2003-04-01 | 最終更新日 | 2021-10-27 | 実験手法 | SOLUTION NMR | 主引用文献 | The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity Embo J., 22, 2003
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1MK3
| SOLUTION STRUCTURE OF HUMAN BCL-W PROTEIN | 分子名称: | Apoptosis regulator Bcl-W | 著者 | Denisov, A.Y, Madiraju, M.S, Chen, G, Khadir, A, Beauparlant, P, Attardo, G, Shore, G.C, Gehring, K. | 登録日 | 2002-08-28 | 公開日 | 2003-06-03 | 最終更新日 | 2021-10-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix J.BIOL.CHEM., 278, 2003
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1PQ0
| Crystal structure of mouse Bcl-xl | 分子名称: | Apoptosis regulator Bcl-X | 著者 | Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W. | 登録日 | 2003-06-17 | 公開日 | 2003-09-23 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function Immunity, 19, 2003
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6UVC
| Crystal structure of BCL-XL bound to compound 8: (R)-3-(Benzylthio)-2-(3-(2-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)propanoic acid | 分子名称: | (R)-3-(Benzylthio)-2-(3-(2-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1, ... | 著者 | Roy, M.J, Birkinshaw, R, Lessene, G, Czabotar, P.E. | 登録日 | 2019-11-02 | 公開日 | 2021-05-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2. J.Med.Chem., 64, 2021
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6UVE
| Crystal structure of BCL-XL bound to compound 7: (R)-3-(Benzylthio)-2-(3-(4-chloro-[1,1':2',1'':3'',1'''-quaterphenyl]-4'''-carbonyl)-3-(4-methylbenzyl)ureido)propanoic acid | 分子名称: | (R)-3-(Benzylthio)-2-(3-(4-chloro-[1,1':2',1'':3'',1'''-quaterphenyl]-4'''-carbonyl)-3-(4-methylbenzyl)ureido)propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1 | 著者 | Roy, M.J, Lessene, G, Czabotar, P.E. | 登録日 | 2019-11-02 | 公開日 | 2021-05-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2. J.Med.Chem., 64, 2021
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6UVD
| Crystal structure of BCL-XL bound to compound 2: (2R)-3-(Benzylsulfanyl)-2-({[(4-methylphenyl)methyl] [(4 phenylphenyl)carbonyl] carbamoyl}amino) propanoic acid | 分子名称: | (2R)-3-(Benzylsulfanyl)-2-({[(4-methylphenyl)methyl] [(4 phenylphenyl)carbonyl] carbamoyl}amino) propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1, ... | 著者 | Roy, M.J, Birkinshaw, R, Lessene, G, Czabotar, P.E. | 登録日 | 2019-11-02 | 公開日 | 2021-05-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2. J.Med.Chem., 64, 2021
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6UVH
| Crystal structure of BCL-XL bound to compound 15: (R)-2-(3-(2-((4'-Chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid | 分子名称: | (R)-2-(3-(2-((4'-Chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1, ... | 著者 | Roy, M.J, Lessene, G, Czabotar, P.E. | 登録日 | 2019-11-02 | 公開日 | 2021-05-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2. J.Med.Chem., 64, 2021
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6UVF
| Crystal structure of BCL-XL bound to compound 12: (R)-2-(3-([1,1'-Biphenyl]-4-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid | 分子名称: | (R)-2-(3-([1,1'-Biphenyl]-4-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1, ... | 著者 | Roy, M.J, Lessene, G, Czabotar, P.E. | 登録日 | 2019-11-02 | 公開日 | 2021-05-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2. J.Med.Chem., 64, 2021
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6UVG
| Crystal structure of BCL-XL bound to compound 13: (R)-2-(3-([1,1'-Biphenyl]-4-carbonyl)-3-(4-methylbenzyl)ureido)-3-(((3R,5R,7R)-adamantan-1-ylmethyl)sulfonyl)propanoic acid | 分子名称: | (R)-2-(3-([1,1'-Biphenyl]-4-carbonyl)-3-(4-methylbenzyl)ureido)-3-(((3R,5R,7R)-adamantan-1-ylmethyl)sulfonyl)propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1, ... | 著者 | Roy, M.J, Lessene, G, Czabotar, P.E. | 登録日 | 2019-11-02 | 公開日 | 2021-05-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2. J.Med.Chem., 64, 2021
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6VWC
| Crystal structure of Bcl-xL in complex with tetrahydroisoquinoline-pyridine based inhibitors | 分子名称: | 6-{8-[(1,3-benzothiazol-2-yl)carbamoyl]-3,4-dihydroisoquinolin-2(1H)-yl}-3-{1-[(pyridin-4-yl)methyl]-1H-pyrazol-4-yl}pyridine-2-carboxylic acid, Bcl-2-like protein 1 | 著者 | Judge, R.A, Judd, A.S. | 登録日 | 2020-02-19 | 公開日 | 2020-10-21 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.604 Å) | 主引用文献 | Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X L Inhibitor. Acs Med.Chem.Lett., 11, 2020
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4BPK
| Bcl-xL bound to alpha beta Puma BH3 peptide 5 | 分子名称: | 1,2-ETHANEDIOL, ALPHA BETA BH3-PEPTIDE, BCL-2-LIKE PROTEIN 1, ... | 著者 | Smith, B.J, Lee, E.F, Checco, J.W, Gellman, S.H, Fairlie, W.D. | 登録日 | 2013-05-27 | 公開日 | 2014-04-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.756 Å) | 主引用文献 | Structure-Guided Rational Design of Alpha/Beta-Peptide Foldamers with High Affinity for Bcl-2 Family Prosurvival Proteins. Chembiochem, 14, 2013
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4C5D
| Crystal structure of Bcl-xL in complex with benzoylurea compound (42) | 分子名称: | (R)-3-(4-BROMOBENZYLTHIO)-2-(3-(3-((2,4-DIFLUOROPHENYL)ETHYNYL)BENZOYL)-3-PROPYLUREIDO)PROPANOIC ACID, 1,2-ETHANEDIOL, BCL-2-LIKE PROTEIN 1, ... | 著者 | Roy, M.J, Brady, R.M, Lessene, G, Colman, P.M, Czabotar, P.E. | 登録日 | 2013-09-11 | 公開日 | 2014-02-05 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | De-Novo Designed Library of Benzoylureas as Inhibitors of Bcl-Xl: Synthesis, Structural and Biochemical Characterization. J.Med.Chem., 57, 2014
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4C52
| Crystal structure of Bcl-xL in complex with benzoylurea compound (39b) | 分子名称: | (R)-2-(3-(3-((2,4-DIFLUOROPENYL)ETHYNYL)BENZOYL)-3-PROPYLUREIDO)-3-(ISOBUTYLTHIO) PROPANOIC ACID, 1,2-ETHANEDIOL, BCL-2-LIKE PROTEIN 1, ... | 著者 | Roy, M.J, Brady, R.M, Lessene, G, Colman, P.M, Czabotar, P.E. | 登録日 | 2013-09-10 | 公開日 | 2014-02-05 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | 主引用文献 | De-Novo Designed Library of Benzoylureas as Inhibitors of Bcl-Xl: Synthesis, Structural and Biochemical Characterization. J.Med.Chem., 57, 2014
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4CIM
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4CIN
| Complex of Bcl-xL with its BH3 domain | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BCL-2-LIKE PROTEIN 1, ... | 著者 | Colman, P.M, Lee, E.F, Fairlie, W.D. | 登録日 | 2013-12-12 | 公開日 | 2014-11-12 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.693 Å) | 主引用文献 | The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains J.Biol.Chem., 289, 2014
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4AQ3
| HUMAN BCL-2 WITH PHENYLACYLSULFONAMIDE INHIBITOR | 分子名称: | APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, N,N-dibutyl-4-chloranyl-1-[2-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)-4-[(7-iodanylnaphthalen-2-yl)sulfonylcarbamoyl]phenyl]-5-methyl-pyrazole-3-carboxamide | 著者 | Bertrand, J.A, Fasolini, M, Modugno, M. | 登録日 | 2012-04-12 | 公開日 | 2012-06-06 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Identification of a Phenylacylsulfonamide Series of Dual Bcl-2/Bcl-Xl Antagonists. Bioorg.Med.Chem.Lett., 22, 2012
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