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4AQ3

HUMAN BCL-2 WITH PHENYLACYLSULFONAMIDE INHIBITOR

Summary for 4AQ3
Entry DOI10.2210/pdb4aq3/pdb
Related1BXL 1G5J 1G5M 1GJH 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 1YSW 2B48 2W3L 2XA0 2YJ1 4A1U 4A1W
DescriptorAPOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, N,N-dibutyl-4-chloranyl-1-[2-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)-4-[(7-iodanylnaphthalen-2-yl)sulfonylcarbamoyl]phenyl]-5-methyl-pyrazole-3-carboxamide (2 entities in total)
Functional Keywordsapoptosis, chimera
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationMitochondrion outer membrane; Single-pass membrane protein: P10415
Total number of polymer chains6
Total formula weight122255.24
Authors
Bertrand, J.A.,Fasolini, M.,Modugno, M. (deposition date: 2012-04-12, release date: 2012-06-06, Last modification date: 2012-11-21)
Primary citationPerez, H.L.,Banfi, P.,Bertrand, J.A.,Cai, Z.W.,Grebinski, J.W.,Kim, K.,Lippy, J.,Modugno, M.,Naglich, J.,Schmidt, R.J.,Tebben, A.,Vianello, P.,Wei, D.D.,Zhang, L.,Galvani, A.,Lombardo, L.J.,Borzilleri, R.M.
Identification of a Phenylacylsulfonamide Series of Dual Bcl-2/Bcl-Xl Antagonists.
Bioorg.Med.Chem.Lett., 22:3946-, 2012
Cited by
PubMed: 22608961
DOI: 10.1016/J.BMCL.2012.04.103
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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