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PDB: 339 results Info pages Status search Chemie search BIRD

c-FLIPL protease-like domain
Descriptor:	CASP8 and FADD-like apoptosis regulator
Authors:	Jeffrey, P.D, Yu, J.W, Shi, Y.
Deposit date:	2009-04-10
Release date:	2009-04-28
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Mechanism of procaspase-8 activation by c-FLIPL. Proc.Natl.Acad.Sci.USA, 106, 2009

3H11

Zymogen caspase-8:c-FLIPL protease domain complex
Descriptor:	CASP8 and FADD-like apoptosis regulator, Caspase-8, IETD aldehyde inhibitor
Authors:	Jeffrey, P.D, Yu, J.W, Shi, Y.
Deposit date:	2009-04-10
Release date:	2009-04-28
Last modified:	2021-10-13
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Mechanism of procaspase-8 activation by c-FLIPL. Proc.Natl.Acad.Sci.USA, 106, 2009

3H0E

3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as Potent Non-Peptidic Inhibitors of Caspase-3
Descriptor:	(10S)-3,3-dimethyl-8-{[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl}-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol, Caspase-3
Authors:	Xu, W.
Deposit date:	2009-04-09
Release date:	2009-11-17
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (1.997 Å)
Cite:	3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3 Bioorg.Med.Chem., 17, 2009

3GJT

Caspase-3 Binds Diverse P4 Residues in Peptides
Descriptor:	Caspase-3 subunit p12, Caspase-3 subunit p17, peptide inhibitor
Authors:	Fang, B, Fu, G, Agniswamy, J, Harrison, R.W, Weber, I.T.
Deposit date:	2009-03-09
Release date:	2009-03-24
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling. Apoptosis, 14, 2009

3GJS

Caspase-3 Binds Diverse P4 Residues in Peptides
Descriptor:	Ac-YVAD-Cho inhibitor, Caspase-3 subunit p12, Caspase-3 subunit p17
Authors:	Fang, B, Fu, G, Agniswamy, J, Harrison, R.W, Weber, I.T.
Deposit date:	2009-03-09
Release date:	2009-03-24
Last modified:	2011-08-17
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling. Apoptosis, 14, 2009

3GJR

Caspase-3 Binds Diverse P4 Residues in Peptides
Descriptor:	Caspase-3 subunit p12, Caspase-3 subunit p17, GLYCEROL, ...
Authors:	Fang, B, Fu, G, Agniswamy, J, Harrison, R.W, Weber, I.T.
Deposit date:	2009-03-09
Release date:	2009-03-24
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling. Apoptosis, 14, 2009

3GJQ

Caspase-3 Binds Diverse P4 Residues in Peptides
Descriptor:	Caspase-3 subunit p12, Caspase-3 subunit p17, peptide inhibitor
Authors:	Fang, B, Fu, G, Agniswamy, J, Harrison, R.W, Weber, I.T.
Deposit date:	2009-03-09
Release date:	2009-03-24
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling. Apoptosis, 14, 2009

3EDR

The crystal structure of caspase-7 in complex with Acetyl-LDESD-CHO
Descriptor:	Caspase-7, Inhibitor Ac-ldesd-cho peptide
Authors:	Agniswamy, J.
Deposit date:	2008-09-03
Release date:	2008-10-28
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Structural basis for executioner caspase recognition of P5 position in substrates. Apoptosis, 13, 2008

3EDQ

Crystal structure of Caspase-3 with inhibitor AC-LDESD-CHO
Descriptor:	AC-LDESD-CHO peptide, Caspase-3
Authors:	Fu, G.
Deposit date:	2008-09-03
Release date:	2008-10-28
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.61 Å)
Cite:	Structural basis for executioner caspase recognition of P5 position in substrates. Apoptosis, 13, 2008

3E4C

Procaspase-1 zymogen domain crystal structure
Descriptor:	Caspase-1, MAGNESIUM ION
Authors:	Elliott, J.M, Rouge, L, Wiesmann, C, Scheer, J.M.
Deposit date:	2008-08-11
Release date:	2008-12-30
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation J.Biol.Chem., 284, 2009

3DEK

Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors
Descriptor:	Caspase-3, N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
Authors:	Wu, J, Du, J, Li, J, Ding, J.
Deposit date:	2008-06-10
Release date:	2008-09-02
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008

3DEJ

Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors
Descriptor:	(1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3
Authors:	Wu, J, Du, J, Li, J, Ding, J.
Deposit date:	2008-06-10
Release date:	2008-09-02
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008

3DEI

Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors
Descriptor:	(1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3
Authors:	Wu, J, Du, J, Li, J, Ding, J.
Deposit date:	2008-06-10
Release date:	2008-09-02
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008

3DEH

Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors
Descriptor:	Caspase-3, isoquinoline-1,3,4(2H)-trione
Authors:	Wu, J, Du, J, Li, J, Ding, J.
Deposit date:	2008-06-10
Release date:	2008-09-02
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008

3D6M

Crystal structure of human caspase-1 with a naturally-occurring Lys319->Arg substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Rosen-Wolff, A, Roesler, J, Romanowski, M.J.
Deposit date:	2008-05-19
Release date:	2010-03-02
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008

3D6H

Crystal structure of human caspase-1 with a naturally-occurring Asn263->Ser substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, Caspase-1 precursor, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Rosen-Wolff, A, Roesler, J, Romanowski, M.J.
Deposit date:	2008-05-19
Release date:	2010-03-02
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008

3D6F

Crystal structure of human caspase-1 with a naturally-occurring Arg240->Gln substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Rosen-Wolff, A, Roesler, J, Romanowski, M.J.
Deposit date:	2008-05-19
Release date:	2010-03-02
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published

3BIJ

Crystal structure of protein GSU0716 from Geobacter sulfurreducens. Northeast Structural Genomics target GsR13
Descriptor:	Uncharacterized protein GSU0716
Authors:	Forouhar, F, Neely, H, Su, M, Seetharaman, J, Benach, J, Conover, K, Fang, Y, Xiao, R, Owen, L.A, Maglaqui, M, Cunningham, K, Baran, M.C, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:	2007-11-30
Release date:	2007-12-11
Last modified:	2017-10-25
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Crystal structure of protein GSU0716 from Geobacter sulfurreducens. To be Published

2Y1L

Caspase-8 in Complex with DARPin-8.4
Descriptor:	1,2-ETHANEDIOL, AC-IETD-CHO, CASPASE-8, ...
Authors:	Barandun, J, Schroeder, T, Mittl, P.R.E, Grutter, M.G.
Deposit date:	2010-12-08
Release date:	2011-12-28
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Caspase-8 in Complex with Darpin-8.4 To be Published

2Y0B

Caspase-3 in Complex with an Inhibitory DARPin-3.4_S76R
Descriptor:	(4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CASPASE-3, ...
Authors:	Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G.
Deposit date:	2010-12-01
Release date:	2011-12-21
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors. Structure, 21, 2013

2XZT

Caspase-3 in Complex with DARPin-3.4_I78S
Descriptor:	(4R)-2-METHYLPENTANE-2,4-DIOL, CASPASE-3, DARPIN-3.4_I78S
Authors:	Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G.
Deposit date:	2010-11-29
Release date:	2011-12-14
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Caspase-3 in Complex with Darpin-3.4_I78S To be Published

2XZD

Caspase-3 in Complex with an Inhibitory DARPin-3.4
Descriptor:	(4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CASPASE-3, ...
Authors:	Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G.
Deposit date:	2010-11-24
Release date:	2011-12-14
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors. Structure, 21, 2013

2XYP

Caspase-3:CAS26049945
Descriptor:	CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17, PHENYLMETHYL N-[(2S)-4-CHLORO-3-OXO-1-PHENYL-BUTAN-2-YL]CARBAMATE
Authors:	Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R.
Deposit date:	2010-11-18
Release date:	2011-08-17
Last modified:	2017-06-28
Method:	X-RAY DIFFRACTION (1.86 Å)
Cite:	In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety. Acta Crystallogr.,Sect.F, 67, 2011

2XYH

Caspase-3:CAS60254719
Descriptor:	5-CHLORO-4-OXOPENTANOIC ACID, CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17
Authors:	Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R.
Deposit date:	2010-11-17
Release date:	2011-08-17
Method:	X-RAY DIFFRACTION (1.89 Å)
Cite:	In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety. Acta Crystallogr.,Sect.F, 67, 2011

2XYG

Caspase-3:CAS329306
Descriptor:	CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17, N-[(2S)-4-chloro-3-oxo-1-phenyl-butan-2-yl]-4-methyl-benzenesulfonamide
Authors:	Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R.
Deposit date:	2010-11-17
Release date:	2011-08-17
Method:	X-RAY DIFFRACTION (1.54 Å)
Cite:	In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety. Acta Crystallogr.,Sect.F, 67, 2011

<3 4 5 6 7 8 91011 12 13 14 >

Total results:	339
Displayed results:	25
Sorted by:	PDBID descending
Query:	PF00656