3H0E
3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as Potent Non-Peptidic Inhibitors of Caspase-3
Summary for 3H0E
Entry DOI | 10.2210/pdb3h0e/pdb |
Related | 1CP3 |
Descriptor | Caspase-3, (10S)-3,3-dimethyl-8-{[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl}-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol (3 entities in total) |
Functional Keywords | caspase-3, protein-inhibitor complex, apoptosis, cytoplasm, hydrolase, phosphoprotein, polymorphism, protease, s-nitrosylation, thiol protease, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P42574 |
Total number of polymer chains | 2 |
Total formula weight | 59633.93 |
Authors | |
Primary citation | Havran, L.M.,Chong, D.C.,Childers, W.E.,Dollings, P.J.,Dietrich, A.,Harrison, B.L.,Marathias, V.,Tawa, G.,Aulabaugh, A.,Cowling, R.,Kapoor, B.,Xu, W.,Mosyak, L.,Moy, F.,Hum, W.T.,Wood, A.,Robichaud, A.J. 3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3 Bioorg.Med.Chem., 17:7755-7768, 2009 Cited by PubMed: 19836248DOI: 10.1016/j.bmc.2009.09.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.997 Å) |
Structure validation
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