3H11

Zymogen caspase-8:c-FLIPL protease domain complex

Summary for 3H11

• Entry DOI: 10.2210/pdb3h11/pdb
• Related: 3H13
• Descriptor: CASP8 and FADD-like apoptosis regulator, Caspase-8, IETD aldehyde inhibitor, ... (4 entities in total)
• Functional Keywords: cell death, apoptosis, caspase, alternative splicing, host-virus interaction, polymorphism, cytoplasm, disease mutation, hydrolase, phosphoprotein, protease, thiol protease, zymogen
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q14790
• Total number of polymer chains: 3
• Total formula weight: 62982.91

Authors

Jeffrey, P.D.,Yu, J.W.,Shi, Y. (deposition date: 2009-04-10, release date: 2009-04-28, Last modification date: 2021-10-13)

• Primary citation: Yu, J.W.,Jeffrey, P.D.,Shi, Y.; Mechanism of procaspase-8 activation by c-FLIPL.; Proc.Natl.Acad.Sci.USA, 106:8169-8174, 2009; PubMed: 19416807; DOI: 10.1073/pnas.0812453106

Experimental method

X-RAY DIFFRACTION (1.9 Å)