7MBU
| Cryo-EM structure of zebrafish TRPM5 E337A mutant in the presence of 5 mM calcium (high calcium occupancy in the transmembrane domain) | 分子名称: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ruan, Z, Lu, W, Du, J, Haley, E. | 登録日 | 2021-04-01 | 公開日 | 2021-07-07 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY | 主引用文献 | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nat.Struct.Mol.Biol., 28, 2021
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7MBV
| Cryo-EM structure of zebrafish TRPM5 in the presence of 5 mM calcium and 0.5 mM NDNA | 分子名称: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ruan, Z, Lu, W, Du, J, Haley, E. | 登録日 | 2021-04-01 | 公開日 | 2021-07-07 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nat.Struct.Mol.Biol., 28, 2021
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5ZX5
| 3.3 angstrom structure of mouse TRPM7 with EDTA | 分子名称: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 7 | 著者 | Zhang, J, Li, Z, Duan, J, Li, J, Hulse, R.E, Santa-Cruz, A, Abiria, S.A, Krapivinsky, G, Clapham, D.E. | 登録日 | 2018-05-18 | 公開日 | 2018-10-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6A90
| Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana and Dc1a | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mu-diguetoxin-Dc1a, ... | 著者 | Shen, H.Z, li, Z.Q, Jiang, Y, Pan, X.J, Wu, J.P, Cristofori-Armstrong, B, Smith, J.J, Chin, Y.K.Y, Lei, J.L, Zhou, Q, King, G.F, Yan, N. | 登録日 | 2018-07-11 | 公開日 | 2018-08-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science, 362, 2018
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6U84
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6U86
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6A91
| Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with saxitoxin and Dc1a | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Shen, H.Z, li, Z.Q, Jiang, Y, Pan, X.J, Wu, J.P, Cristofori-Armstrong, B, Smith, J.J, Chin, Y.K.Y, Lei, J.L, Zhou, Q, King, G.F, Yan, N. | 登録日 | 2018-07-11 | 公開日 | 2018-08-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science, 362, 2018
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6A95
| Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with tetrodotoxin and Dc1a | 分子名称: | (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Shen, H.Z, li, Z.Q, Jiang, Y, Pan, X.J, Wu, J.P, Cristofori-Armstrong, B, Smith, J.J, Chin, Y.K.Y, Lei, J.L, Zhou, Q, King, G.F, Yan, N. | 登録日 | 2018-07-11 | 公開日 | 2018-08-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science, 362, 2018
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6U8A
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6U88
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6AGF
| Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Pan, X.J, li, Z.Q, Zhou, Q, Shen, H.Z, Wu, K, Huang, X.S, Chen, J.F, Zhang, J.R, Zhu, X.C, Lei, J.L, Xiong, W, Gong, H.P, Xiao, B.L, Yan, N. | 登録日 | 2018-08-11 | 公開日 | 2018-10-10 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta 1. Science, 362, 2018
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6V00
| structure of human KCNQ1-KCNE3-CaM complex | 分子名称: | CALCIUM ION, Calmodulin-1, MCherry fluorescent protein,Potassium voltage-gated channel subfamily E member 3, ... | 著者 | Mackinnon, R, Sun, J. | 登録日 | 2019-11-16 | 公開日 | 2019-12-04 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural Basis of Human KCNQ1 Modulation and Gating. Cell, 180, 2020
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6UZZ
| structure of human KCNQ1-CaM complex | 分子名称: | CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 | 著者 | Mackinnon, R, Sun, J. | 登録日 | 2019-11-16 | 公開日 | 2019-12-04 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural Basis of Human KCNQ1 Modulation and Gating. Cell, 180, 2020
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6BCL
| cryo-EM structure of TRPM4 in apo state with long coiled coil at 3.5 angstrom resolution | 分子名称: | SODIUM ION, Transient receptor potential cation channel subfamily M member 4 | 著者 | Guo, J, She, J, Chen, Q, Bai, X, Jiang, Y. | 登録日 | 2017-10-20 | 公開日 | 2017-12-13 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Structures of the calcium-activated, non-selective cation channel TRPM4. Nature, 552, 2017
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6UZ3
| Cardiac sodium channel | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jiang, D, Shi, H, Tonggu, L, Lenaeus, M.J, Zheng, N, Catterall, W.A. | 登録日 | 2019-11-14 | 公開日 | 2020-01-01 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the Cardiac Sodium Channel. Cell, 180, 2020
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6BCJ
| cryo-EM structure of TRPM4 in apo state with short coiled coil at 3.1 angstrom resolution | 分子名称: | SODIUM ION, Transient receptor potential cation channel subfamily M member 4 | 著者 | Guo, J, She, J, Chen, Q, Bai, X, Jiang, Y. | 登録日 | 2017-10-20 | 公開日 | 2017-12-13 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Structures of the calcium-activated, non-selective cation channel TRPM4. Nature, 552, 2017
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5TJ6
| Ca2+ bound aplysia Slo1 | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, High conductance calcium-activated potassium channel, ... | 著者 | MacKinnon, R, Tao, X, Hite, R.K. | 登録日 | 2016-10-03 | 公開日 | 2016-12-14 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel. Nature, 541, 2017
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5TJI
| Ca2+ bound aplysia Slo1 | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, High conductance calcium-activated potassium channel | 著者 | MacKinnon, R, Tao, X, Hite, R.K. | 登録日 | 2016-10-04 | 公開日 | 2016-12-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis for gating the high-conductance Ca(2+)-activated K(+) channel. Nature, 541, 2017
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6BCQ
| cryo-EM structure of TRPM4 in ATP bound state with long coiled coil at 3.3 angstrom resolution | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Transient receptor potential cation channel subfamily M member 4 | 著者 | Guo, J, She, J, Chen, Q, Bai, X, Jiang, Y. | 登録日 | 2017-10-20 | 公開日 | 2017-12-13 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structures of the calcium-activated, non-selective cation channel TRPM4. Nature, 552, 2017
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6UZA
| Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473 | 分子名称: | 2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Bai, Y, Yu, X, Huang, X, Chen, H. | 登録日 | 2019-11-14 | 公開日 | 2020-03-18 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural basis for pharmacological modulation of the TRPC6 channel. Elife, 9, 2020
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6V22
| Cryo-EM structure of Ca2+-bound hsSlo1-beta4 channel complex | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Tao, X, MacKinnon, R. | 登録日 | 2019-11-22 | 公開日 | 2019-12-25 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular structures of the human Slo1 K + channel in complex with beta 4. Elife, 8, 2019
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6BCO
| cryo-EM structure of TRPM4 in ATP bound state with short coiled coil at 2.9 angstrom resolution | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Transient receptor potential cation channel subfamily M member 4 | 著者 | Guo, J, She, J, Chen, Q, Bai, X, Jiang, Y. | 登録日 | 2017-10-20 | 公開日 | 2017-12-13 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structures of the calcium-activated, non-selective cation channel TRPM4. Nature, 552, 2017
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6BQV
| Human TRPM4 ion channel in lipid nanodiscs in a calcium-bound state | 分子名称: | CALCIUM ION, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 4 | 著者 | Autzen, H.E, Myasnikov, A.G, Campbell, M.G, Asarnow, D, Julius, D, Cheng, Y. | 登録日 | 2017-11-28 | 公開日 | 2017-12-20 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the human TRPM4 ion channel in a lipid nanodisc. Science, 359, 2018
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6BQR
| Human TRPM4 ion channel in lipid nanodiscs in a calcium-free state | 分子名称: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 4 | 著者 | Autzen, H.E, Myasnikov, A.G, Campbell, M.G, Asarnow, D, Julius, D, Cheng, Y. | 登録日 | 2017-11-28 | 公開日 | 2017-12-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of the human TRPM4 ion channel in a lipid nanodisc. Science, 359, 2018
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6BO4
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