6UZA

Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473

Summary for 6UZA

• Entry DOI: 10.2210/pdb6uza/pdb
• Related: 6UZ8
• EMDB information: 20953 20954
• Descriptor: Short transient receptor potential channel 6, 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile, 2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, ... (5 entities in total)
• Functional Keywords: trp channel, antagonist, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 398056.10

Authors

Bai, Y.,Yu, X.,Huang, X.,Chen, H. (deposition date: 2019-11-14, release date: 2020-03-18)

• Primary citation: Bai, Y.,Yu, X.,Chen, H.,Horne, D.,White, R.,Wu, X.,Lee, P.,Gu, Y.,Ghimire-Rijal, S.,Lin, D.C.,Huang, X.; Structural basis for pharmacological modulation of the TRPC6 channel.; Elife, 9:-, 2020; PubMed: 32149605; DOI: 10.7554/eLife.53311

Experimental method

ELECTRON MICROSCOPY (3.08 Å)