6UZA
Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| A | 0007338 | biological_process | single fertilization |
| A | 0015279 | molecular_function | store-operated calcium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0032414 | biological_process | positive regulation of ion transmembrane transporter activity |
| A | 0034703 | cellular_component | cation channel complex |
| A | 0036057 | cellular_component | slit diaphragm |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0051480 | biological_process | regulation of cytosolic calcium ion concentration |
| A | 0051928 | biological_process | positive regulation of calcium ion transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| B | 0007338 | biological_process | single fertilization |
| B | 0015279 | molecular_function | store-operated calcium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0032414 | biological_process | positive regulation of ion transmembrane transporter activity |
| B | 0034703 | cellular_component | cation channel complex |
| B | 0036057 | cellular_component | slit diaphragm |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0051480 | biological_process | regulation of cytosolic calcium ion concentration |
| B | 0051928 | biological_process | positive regulation of calcium ion transport |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005261 | molecular_function | monoatomic cation channel activity |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006812 | biological_process | monoatomic cation transport |
| C | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| C | 0007338 | biological_process | single fertilization |
| C | 0015279 | molecular_function | store-operated calcium channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0032414 | biological_process | positive regulation of ion transmembrane transporter activity |
| C | 0034703 | cellular_component | cation channel complex |
| C | 0036057 | cellular_component | slit diaphragm |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0051480 | biological_process | regulation of cytosolic calcium ion concentration |
| C | 0051928 | biological_process | positive regulation of calcium ion transport |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005262 | molecular_function | calcium channel activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006812 | biological_process | monoatomic cation transport |
| D | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| D | 0007338 | biological_process | single fertilization |
| D | 0015279 | molecular_function | store-operated calcium channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0032414 | biological_process | positive regulation of ion transmembrane transporter activity |
| D | 0034703 | cellular_component | cation channel complex |
| D | 0036057 | cellular_component | slit diaphragm |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0051480 | biological_process | regulation of cytosolic calcium ion concentration |
| D | 0051928 | biological_process | positive regulation of calcium ion transport |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue R0G A 1001 |
| Chain | Residue |
| A | LYS442 |
| A | HIS446 |
| A | GLU509 |
| A | ARG609 |
| A | TYR612 |
| A | ILE613 |
| A | SER752 |
| A | TYR753 |
| A | ARG758 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue S9Y A 1002 |
| Chain | Residue |
| A | TRP526 |
| A | PHE607 |
| A | ALA611 |
| A | GLN624 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SBJ A 1003 |
| Chain | Residue |
| A | GLU672 |
| A | PHE675 |
| A | TRP680 |
| B | ASN702 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue Y01 A 1004 |
| Chain | Residue |
| A | TRP391 |
| A | TYR392 |
| A | PHE407 |
| A | PHE440 |
| A | THR451 |
| A | ALA616 |
| A | ASN617 |
| A | TRP750 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SBJ A 1005 |
| Chain | Residue |
| A | ASN702 |
| D | GLU672 |
| D | PHE675 |
| D | TRP680 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue Y01 A 1006 |
| Chain | Residue |
| A | PHE699 |
| A | ASN702 |
| A | ILE703 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue Y01 B 1001 |
| Chain | Residue |
| B | PHE699 |
| B | ASN702 |
| B | ILE703 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue R0G B 1002 |
| Chain | Residue |
| B | LYS442 |
| B | HIS446 |
| B | GLU509 |
| B | ARG609 |
| B | TYR612 |
| B | ILE613 |
| B | SER752 |
| B | TYR753 |
| B | ARG758 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue S9Y B 1003 |
| Chain | Residue |
| B | TRP526 |
| B | PHE607 |
| B | ALA611 |
| B | GLN624 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue SBJ B 1004 |
| Chain | Residue |
| B | GLU672 |
| B | PHE675 |
| B | TRP680 |
| C | ASN702 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue Y01 B 1005 |
| Chain | Residue |
| B | TRP391 |
| B | TYR392 |
| B | PHE407 |
| B | PHE440 |
| B | THR451 |
| B | ALA616 |
| B | ASN617 |
| B | TRP750 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue Y01 C 1001 |
| Chain | Residue |
| C | PHE699 |
| C | ASN702 |
| C | ILE703 |
| site_id | AD4 |
| Number of Residues | 9 |
| Details | binding site for residue R0G C 1002 |
| Chain | Residue |
| C | LYS442 |
| C | HIS446 |
| C | GLU509 |
| C | ARG609 |
| C | TYR612 |
| C | ILE613 |
| C | SER752 |
| C | TYR753 |
| C | ARG758 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue S9Y C 1003 |
| Chain | Residue |
| C | TRP526 |
| C | PHE607 |
| C | ALA611 |
| C | GLN624 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue SBJ C 1004 |
| Chain | Residue |
| C | GLU672 |
| C | PHE675 |
| C | TRP680 |
| D | ASN702 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue Y01 C 1005 |
| Chain | Residue |
| C | TRP391 |
| C | TYR392 |
| C | PHE407 |
| C | PHE440 |
| C | THR451 |
| C | ALA616 |
| C | ASN617 |
| C | TRP750 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue Y01 D 1001 |
| Chain | Residue |
| D | PHE699 |
| D | ASN702 |
| D | ILE703 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue R0G D 1002 |
| Chain | Residue |
| D | ARG758 |
| D | LYS442 |
| D | HIS446 |
| D | GLU509 |
| D | ARG609 |
| D | TYR612 |
| D | ILE613 |
| D | SER752 |
| D | TYR753 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue S9Y D 1003 |
| Chain | Residue |
| D | TRP526 |
| D | PHE607 |
| D | ALA611 |
| D | GLN624 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue Y01 D 1004 |
| Chain | Residue |
| D | TRP391 |
| D | TYR392 |
| D | PHE407 |
| D | PHE440 |
| D | THR451 |
| D | ALA616 |
| D | ASN617 |
| D | TRP750 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 480 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| C | PRO439-MET459 | |
| A | PRO439-MET459 | |
| A | THR488-ALA508 | |
| A | LEU522-ILE542 | |
| A | ILE593-ILE613 | |
| A | PHE637-SER657 | |
| A | LEU707-ILE727 | |
| B | PRO439-MET459 | |
| B | THR488-ALA508 | |
| B | LEU522-ILE542 | |
| B | ILE593-ILE613 | |
| B | PHE637-SER657 | |
| B | LEU707-ILE727 | |
| C | THR488-ALA508 | |
| C | LEU522-ILE542 | |
| C | ILE593-ILE613 | |
| C | PHE637-SER657 | |
| C | LEU707-ILE727 | |
| D | PRO439-MET459 | |
| D | THR488-ALA508 | |
| D | LEU522-ILE542 | |
| D | ILE593-ILE613 | |
| D | PHE637-SER657 | |
| D | LEU707-ILE727 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 496 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN460-LYS487 | |
| A | ASN460-LYS487 | |
| A | ALA543-GLN592 | |
| A | TYR658-VAL706 | |
| B | ASN460-LYS487 | |
| B | ALA543-GLN592 | |
| B | TYR658-VAL706 | |
| C | ALA543-GLN592 | |
| C | TYR658-VAL706 | |
| D | ASN460-LYS487 | |
| D | ALA543-GLN592 | |
| D | TYR658-VAL706 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 948 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU509-TYR521 | |
| A | LEU614-LYS636 | |
| A | ASN728-ARG931 | |
| B | GLU509-TYR521 | |
| B | LEU614-LYS636 | |
| B | ASN728-ARG931 | |
| C | GLU509-TYR521 | |
| C | LEU614-LYS636 | |
| C | ASN728-ARG931 | |
| D | GLU509-TYR521 | |
| D | LEU614-LYS636 | |
| D | ASN728-ARG931 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18088087 |
| Chain | Residue | Details |
| B | SER815 | |
| C | SER815 | |
| D | SER815 | |
| A | SER815 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12970363 |
| Chain | Residue | Details |
| B | ASN473 | |
| B | ASN561 | |
| C | ASN473 | |
| C | ASN561 | |
| D | ASN473 | |
| D | ASN561 | |
| A | ASN473 | |
| A | ASN561 |
