7ZJG
 
 | | Probenecid | | 分子名称: | Transient receptor potential cation channel subfamily V member 2 | | 著者 | Zhang, L, Gourdon, P, Zygmunt, P.M. | | 登録日 | 2022-04-11 | | 公開日 | 2023-01-18 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.
Nat Commun, 13, 2022
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6NT3
 | | Cryo-EM structure of a human-cockroach hybrid Nav channel. | | 分子名称: | (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Clairfeuille, T, Rohou, A, Payandeh, J. | | 登録日 | 2019-01-28 | | 公開日 | 2019-02-20 | | 最終更新日 | 2021-08-25 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structures of a human-cockroach hybrid Nav channel in the presence and absence of the alpha-scorpion toxin AaH2.
Science, 2019
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6ND0
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6NT4
 | | Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2. | | 分子名称: | (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Clairfeuille, T, Rohou, A, Payandeh, J. | | 登録日 | 2019-01-28 | | 公開日 | 2019-02-20 | | 最終更新日 | 2021-08-25 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural basis of alpha-scorpion toxin action on Na v channels.
Science, 363, 2019
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6OO7
 | | Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in nanodiscs | | 分子名称: | TRPV2, resiniferatoxin | | 著者 | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | 登録日 | 2019-04-22 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
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6OO5
 | | Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in amphipol resolved to 4.2 A | | 分子名称: | TRPV2, resiniferatoxin | | 著者 | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | 登録日 | 2019-04-22 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
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6OO3
 | | Cryo-EM structure of the C4-symmetric TRPV2/RTx complex in amphipol resolved to 2.9 A | | 分子名称: | TRPV2, resiniferatoxin | | 著者 | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | 登録日 | 2019-04-22 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
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6OO4
 | | Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in amphipol resolved to 3.3 A | | 分子名称: | TRPV2, resiniferatoxin | | 著者 | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | 登録日 | 2019-04-22 | | 公開日 | 2019-05-29 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
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6P6W
 | | Cryo-EM structure of voltage-gated sodium channel NavAb N49K/L109A/M116V/G94C/Q150C disulfide crosslinked mutant in the resting state | | 分子名称: | Fusion of Maltose-binding protein and voltage-gated sodium channel NavAb | | 著者 | Wisedchaisri, G, Tonggu, L, McCord, E, Gamal El-Din, T.M, Wang, L, Zheng, N, Catterall, W.A. | | 登録日 | 2019-06-04 | | 公開日 | 2019-08-14 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel.
Cell, 178, 2019
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6LQA
 | | voltage-gated sodium channel Nav1.5 with quinidine | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Quinidine, Sodium channel protein type 5 subunit alpha | | 著者 | Yan, N, Li, Z, Pan, X, Huang, G. | | 登録日 | 2020-01-13 | | 公開日 | 2021-03-24 | | 最終更新日 | 2021-05-19 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na v 1.5 by the Antiarrhythmic Drug Quinidine*.
Angew.Chem.Int.Ed.Engl., 60, 2021
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6PKW
 | | Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry) | | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | | 著者 | Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y. | | 登録日 | 2019-06-30 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
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6PKV
 | | Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry | | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | | 著者 | Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y. | | 登録日 | 2019-06-30 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
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6MJ2
 | | Human TRPM2 ion channel in a calcium- and ADPR-bound state | | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | | 著者 | Wang, L, Fu, T.M, Xia, S, Wu, H. | | 登録日 | 2018-09-20 | | 公開日 | 2018-12-12 | | 最終更新日 | 2019-01-02 | | 実験手法 | ELECTRON MICROSCOPY (6.36 Å) | | 主引用文献 | Structures and gating mechanism of human TRPM2.
Science, 362, 2018
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6MU2
 | | Structure of full-length IP3R1 channel in the Apo-state | | 分子名称: | Inositol 1,4,5-trisphosphate receptor type 1 | | 著者 | Serysheva, I.I, Fan, G, Baker, M.R, Wang, Z, Seryshev, A, Ludtke, S.J, Baker, M.L. | | 登録日 | 2018-10-22 | | 公開日 | 2018-12-05 | | 最終更新日 | 2019-11-27 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating.
Cell Res., 28, 2018
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6MIX
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6PKX
 | | Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+ | | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 2, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | 著者 | Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y. | | 登録日 | 2019-06-30 | | 公開日 | 2019-08-28 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
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6MIZ
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6MU1
 | | Structure of full-length IP3R1 channel bound with Adenophostin A | | 分子名称: | Adenophostin A, Inositol 1,4,5-trisphosphate receptor type 1 | | 著者 | Serysheva, I.I, Fan, G, Baker, M.R, Wang, Z, Seryshev, A, Ludtke, S.J, Baker, M.L. | | 登録日 | 2018-10-22 | | 公開日 | 2018-12-05 | | 最終更新日 | 2019-11-27 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating.
Cell Res., 28, 2018
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7MBP
 | | Cryo-EM structure of zebrafish TRPM5 in the presence of 1 mM EDTA | | 分子名称: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ruan, Z, Lu, W, Du, J, Haley, E. | | 登録日 | 2021-04-01 | | 公開日 | 2021-09-22 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition.
Nat.Struct.Mol.Biol., 28, 2021
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7N0M
 | | Inactivated state of 2-APB-bound wildtype rat TRPV2 in nanodiscs | | 分子名称: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2 | | 著者 | Pumroy, R.A, Protopopova, A.D, Gallo, P.N, Moiseenkova-Bell, V.Y. | | 登録日 | 2021-05-25 | | 公開日 | 2022-05-04 | | 最終更新日 | 2023-04-05 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural insights into TRPV2 activation by small molecules.
Nat Commun, 13, 2022
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7N0N
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7MBS
 | | Cryo-EM structure of zebrafish TRPM5 in the presence of 6 uM calcium (open state) | | 分子名称: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ruan, Z, Lu, W, Du, J, Haley, E. | | 登録日 | 2021-04-01 | | 公開日 | 2021-07-07 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY | | 主引用文献 | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition.
Nat.Struct.Mol.Biol., 28, 2021
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7MBR
 | | Cryo-EM structure of zebrafish TRPM5 in the presence of 6 uM calcium (apo state) | | 分子名称: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ruan, Z, Lu, W, Du, J, Haley, E. | | 登録日 | 2021-04-01 | | 公開日 | 2021-07-07 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY | | 主引用文献 | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition.
Nat.Struct.Mol.Biol., 28, 2021
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7MBT
 | | Cryo-EM structure of zebrafish TRPM5 E337A mutant in the presence of 5 mM calcium (low calcium occupancy in the transmembrane domain) | | 分子名称: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ruan, Z, Lu, W, Du, J, Haley, E. | | 登録日 | 2021-04-01 | | 公開日 | 2021-07-07 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY | | 主引用文献 | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition.
Nat.Struct.Mol.Biol., 28, 2021
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7MBQ
 | | Cryo-EM structure of zebrafish TRPM5 in the presence of 5 mM calcium | | 分子名称: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ruan, Z, Lu, W, Du, J, Haley, E. | | 登録日 | 2021-04-01 | | 公開日 | 2021-07-07 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition.
Nat.Struct.Mol.Biol., 28, 2021
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