1L0F
 
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1L0E
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8OE5
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1VM1
 | | STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM | | 分子名称: | ACRYLIC ACID, BETA-LACTAMASE SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... | | 著者 | Kuzin, A.P, Nukaga, M, Nukaga, Y, Hujer, A, Bonomo, R.A, Knox, J.R. | | 登録日 | 2004-08-27 | | 公開日 | 2004-09-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam.
Biochemistry, 40, 2001
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7LR9
 | | Crystal structure of KPC-2 S70G/T215P mutant with hydrolyzed imipenem | | 分子名称: | (2R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-(2-methanimidamidoethylsulfanyl)-2,3-dihydro-1H-pyrrole -5-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC | | 著者 | Furey, I, Palzkill, T, Hu, L, Prasad, B.V.V. | | 登録日 | 2021-02-16 | | 公開日 | 2022-08-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | Crystal structure of KPC-2 T215P mutant
To Be Published
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1LI9
 | | Crystal structure of TEM-34 beta-Lactamase at 1.5 Angstrom | | 分子名称: | Class A beta-Lactamase- TEM-34, PHOSPHATE ION, POTASSIUM ION | | 著者 | Wang, X, Minasov, G, Shoichet, B.K. | | 登録日 | 2002-04-17 | | 公開日 | 2002-09-11 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | The structural bases of antibiotic resistance in the clinically derived mutant beta-lactamases TEM-30, TEM-32, and TEM-34.
J.Biol.Chem., 277, 2002
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5VLE
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3TSG
 | | Crystal structure of GES-14 | | 分子名称: | Extended-spectrum beta-lactamase GES-14, GLYCEROL, IODIDE ION | | 著者 | Delbruck, H, Hoffmann, K.M.V, Bebrone, C. | | 登録日 | 2011-09-13 | | 公開日 | 2012-09-26 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 beta-lactamases.
Antimicrob.Agents Chemother., 56, 2012
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5KKF
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1M40
 | | ULTRA HIGH RESOLUTION CRYSTAL STRUCTURE OF TEM-1 | | 分子名称: | BETA-LACTAMASE TEM, PHOSPHATE ION, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, ... | | 著者 | Minasov, G, Wang, X, Shoichet, B.K. | | 登録日 | 2002-07-01 | | 公開日 | 2002-07-17 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (0.85 Å) | | 主引用文献 | An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation.
J.Am.Chem.Soc., 124, 2002
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5KMU
 | | CTX-M-9 beta lactamase mutant - T165W | | 分子名称: | Beta-lactamase, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Latallo, M, Faham, S, Kasson, P.M. | | 登録日 | 2016-06-27 | | 公開日 | 2017-08-02 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme.
Chem Sci, 8, 2017
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4OQI
 | | Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S/G238S mutations | | 分子名称: | CALCIUM ION, SULFATE ION, TEM-94 ES-beta-lactamase | | 著者 | Dellus-Gur, E, Elias, M, Fraser, J.S, Tawfik, D.S. | | 登録日 | 2014-02-09 | | 公開日 | 2015-05-20 | | 最終更新日 | 2018-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Negative Epistasis and Evolvability in TEM-1 beta-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.
J. Mol. Biol., 427, 2015
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6Q35
 | | Crystal structure of GES-5 beta-lactamase in complex with boronic inhibitor cpd 3 | | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase, DIMETHYL SULFOXIDE, ... | | 著者 | Maso, L, Quotadamo, A, Bellio, P, Montanari, M, Venturelli, A, Celenza, G, Costi, M.P, Tondi, D, Cendron, L. | | 登録日 | 2018-12-03 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | X-ray Crystallography Deciphers the Activity of Broad-Spectrum Boronic Acid beta-Lactamase Inhibitors.
Acs Med.Chem.Lett., 10, 2019
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4EBP
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4EQI
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4EUZ
 | | Crystal structure of serratia fonticola carbapenemase SFC-1 S70A-Meropenem complex | | 分子名称: | (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 1,2-ETHANEDIOL, Carbapenem-hydrolizing beta-lactamase SFC-1, ... | | 著者 | Fonseca, F, Spencer, J. | | 登録日 | 2012-04-25 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | | 主引用文献 | The basis for carbapenem hydrolysis by class A beta-lactamases: a combined investigation using crystallography and simulations.
J.Am.Chem.Soc., 134, 2012
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3BYD
 | | Crystal structure of beta-lactamase OXY-1-1 from Klebsiella oxytoca | | 分子名称: | ACETATE ION, Beta-lactamase OXY-1, SULFATE ION | | 著者 | Liang, Y.-H, Wu, S.W, Su, X.-D. | | 登録日 | 2008-01-15 | | 公開日 | 2009-01-20 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Structural insights into the broadened substrate profile of the extended-spectrum beta-lactamase OXY-1-1 from Klebsiella oxytoca
Acta Crystallogr.,Sect.D, 68, 2012
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3C7U
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2QPN
 | | GES-1 beta-lactamase | | 分子名称: | Beta-lactamase GES-1, SULFATE ION | | 著者 | Smith, C.A, Caccamo, M, Kantardjieff, K.A, Vakulenko, S. | | 登録日 | 2007-07-24 | | 公開日 | 2008-08-12 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Structure of GES-1 at atomic resolution: insights into the evolution of carbapenamase activity in the class A extended-spectrum beta-lactamases.
Acta Crystallogr.,Sect.D, 63, 2007
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3BLM
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3CG5
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2QMI
 | | Structure of the octameric penicillin-binding protein homologue from Pyrococcus abyssi | | 分子名称: | 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID, LUTETIUM (III) ION, Pbp related beta-lactamase | | 著者 | Delfosse, V, Girard, E, Moulinier, L, Schultz, P, Mayer, C. | | 登録日 | 2007-07-16 | | 公開日 | 2008-07-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of the archaeal pab87 peptidase reveals a novel self-compartmentalizing protease family
Plos One, 4, 2009
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8TJM
 | | Crystal structure of KPC-44 carbapenemase | | 分子名称: | 1,2-ETHANEDIOL, SULFATE ION, beta-lactamase | | 著者 | Sun, Z, Palzkill, T, Hu, L, Lin, H, Sankaran, B, Wang, J, Prasad, B. | | 登録日 | 2023-07-23 | | 公開日 | 2023-12-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops.
J.Biol.Chem., 300, 2023
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8TN0
 | | Crystal structure of KPC-44 carbapenemase w/o cryoprotectant | | 分子名称: | SULFATE ION, beta-lactamase | | 著者 | Sun, Z, Palzkill, T, Hu, L, Lin, H, Sankaran, B, Wang, J, Prasad, B. | | 登録日 | 2023-07-31 | | 公開日 | 2023-12-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops.
J.Biol.Chem., 300, 2023
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8TMR
 | | Crystal structure of KPC-44 carbapenemase complexed with avibactam | | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1,2-ETHANEDIOL, PHOSPHATE ION, ... | | 著者 | Sun, Z, Palzkill, T, Hu, L, Lin, H, Sankaran, B, Wang, J, Prasad, B. | | 登録日 | 2023-07-30 | | 公開日 | 2023-12-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | | 主引用文献 | Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops.
J.Biol.Chem., 300, 2023
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