PDB: 367 件ウェブページステータス検索Chemie searchBIRD

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8J2E	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R in complex with NADP+ and malonate 分子名称: MALONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR 著者 Ma, Q, Liu, C. 登録日 2023-04-14 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2B	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, in complex with NADP+ and malonate 分子名称: MALONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR 著者 Ma, Q, Liu, C. 登録日 2023-04-14 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
4C7J	11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor 分子名称: 4-cyclopropyl-2-(2-hydroxyethyloxy)-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-1,3-thiazole-5-carboxamide, CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Goldberg, F.W, Dossetter, A.G, Scott, J.S, Robb, G.R, Boyd, S, Groombridge, S.D, Kemmitt, P.D, Sjogren, T, Morentin Gutierrez, P, de Schoolmeester, J, Swales, J.G, Turnbull, A.V, Wild, M.J. 登録日 2013-09-23 公開日 2014-09-03 最終更新日 2018-04-04 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Optimization of Brain Penetrant 11Beta-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet- Induced Obese Mice. J.Med.Chem., 57, 2014
4DC1	Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH 分子名称: Ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Javidpour, P, Tsai, S.-C. 登録日 2012-01-16 公開日 2013-01-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase. Chem.Biol., 20, 2013
4DC0	Crystal Structure of F189W Actinorhodin Polyketide Ketoreductase with NADPH 分子名称: Ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Javidpour, P, Tsai, S.-C. 登録日 2012-01-16 公開日 2013-01-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.813 Å) 主引用文献 The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase. Chem.Biol., 20, 2013
4DBZ	Crystal Structure of V151L Actinorhodin Polyketide Ketoreductase with NADPH 分子名称: Ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Javidpour, P, Tsai, S.-C. 登録日 2012-01-16 公開日 2013-01-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.643 Å) 主引用文献 The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase. Chem.Biol., 20, 2013
4IS2	Crystal structure of the apo form of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 at 1.90 A resolution 分子名称: Bile acid 3-alpha hydroxysteroid dehydrogenase, CHLORIDE ION 著者 Joint Center for Structural Genomics (JCSG) 登録日 2013-01-16 公開日 2013-04-03 最終更新日 2023-02-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the apo form of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 at 1.90 A resolution To be published
8B5U	Crystal structure of Quinonoid dihydropteridine reductase from Leishmania donovani 分子名称: Quinonoid dihydropteridine reductase 著者 Robinson, D.A, Fairlamb, A.H. 登録日 2022-09-24 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of Quinonoid dihydropteridine reductase from Leishmania donovani To Be Published
8B5T	Crystal structure of Quinonoid dihydropteridine reductase from Leishmania major 分子名称: Quinonoid dihydropteridine reductase 著者 Robinson, D.A, Fairlamb, A.H. 登録日 2022-09-24 公開日 2022-10-05 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of Quinonoid dihydropteridine reductase from Leishmania major To Be Published
4DYV	Crystal structure of a short-chain dehydrogenase/reductase SDR from Xanthobacter autotrophicus Py2 分子名称: CHLORIDE ION, Short-chain dehydrogenase/reductase SDR 著者 Agarwal, R, Chamala, S, Evans, B, Foti, R, Hillerich, B, Kar, A, Lafleur, J, Siedel, R, Villigas, G, Zencheck, W, Gizzi, A, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) 登録日 2012-02-29 公開日 2012-03-14 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of a short-chain dehydrogenase/reductase SDR from Xanthobacter autotrophicus Py2 To be Published
4IS3	Crystal structure of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 in complex with a putative NAD(+)-OH- adduct at 2.0 A resolution 分子名称: ACETATE ION, Bile acid 3-alpha hydroxysteroid dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Joint Center for Structural Genomics (JCSG) 登録日 2013-01-16 公開日 2013-04-24 最終更新日 2023-02-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 in complex with a putative NAD(+)-OH- adduct at 2.0 A resolution To be published
4C7K	11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor 分子名称: 2-ethyl-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-4-[(2R)-oxolan-2-yl]-1,3-thiazole-5-carboxamide, CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Goldberg, F.W, Dossetter, A.G, Scott, J.S, Robb, G.R, Boyd, S, Groombridge, S.D, Kemmitt, P.D, Sjogren, T, Morentin Gutierrez, P, de Schoolmeester, J, Swales, J.G, Turnbull, A.V, Wild, M.J. 登録日 2013-09-23 公開日 2014-03-05 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Optimization of Brain Penetrant 11Beta-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet- Induced Obese Mice. J.Med.Chem., 57, 2014
4HWK	Crystal structure of human sepiapterin reductase in complex with sulfapyridine 分子名称: 4-amino-N-(pyridin-2-yl)benzenesulfonamide, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Groenlund Pedersen, M, Pojer, F, Johnsson, K. 登録日 2012-11-08 公開日 2013-06-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs. Science, 340, 2013
4J7X	Crystal structure of human sepiapterin reductase in complex with sulfasalazine 分子名称: 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Groenlund Pedersen, M, Pojer, F, Johnsson, K. 登録日 2013-02-14 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of human sepiapterin reductase in complex with sulfasalazine To be Published
4IJV	Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with 3-[1-(4-chlorophenyl)cyclopropyl]-8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridine 分子名称: 3-[1-(4-chlorophenyl)cyclopropyl]-8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridine, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Sheriff, S. 登録日 2012-12-23 公開日 2014-06-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1). ACS Med Chem Lett, 5, 2014
1WMA	Crystal structure of human CBR1 in complex with Hydroxy-PP 分子名称: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 3-(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)PHENOL, ... 著者 Rauh, D, Bateman, R, Shokat, K.M. 登録日 2004-07-06 公開日 2005-04-26 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 An unbiased cell morphology-based screen for new, biologically active small molecules Plos Biol., 3, 2005
1X7H	Actinorhodin Polyketide Ketoreductase, with NADPH bound 分子名称: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative ketoacyl reductase 著者 Korman, T.P, Hill, J.A, Vu, T.N. 登録日 2004-08-13 公開日 2004-12-14 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity Biochemistry, 43, 2004
1X7G	Actinorhodin Polyketide Ketoreductase, act KR, with NADP bound 分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative ketoacyl reductase 著者 Korman, T.P, Hill, J.A, Vu, T.N. 登録日 2004-08-13 公開日 2004-12-14 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity Biochemistry, 43, 2004
1W4Z	Structure of actinorhodin polyketide (actIII) Reductase 分子名称: FORMIC ACID, KETOACYL REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Hadfield, A.T, Limpkin, C, Teartasin, W, Simpson, T.J, Crosby, J, Crump, M.P. 登録日 2004-08-03 公開日 2004-12-10 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Crystal Structure of the Actiii Actinorhodin Polyketide Reductase; Proposed Mechanism for Acp and Polyketide Binding Structure, 12, 2004
1XG5	Structure of human putative dehydrogenase MGC4172 in complex with NADP 分子名称: ACETIC ACID, ARPG836, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Kavanagh, K, Ng, S, Sharma, S, Vedadi, M, von Delft, F, Walker, J.R, dhe Paganon, S, Bray, J, Oppermann, U, Edwards, A, Arrowsmith, C, Sundstrom, M, Structural Genomics Consortium (SGC) 登録日 2004-09-16 公開日 2004-10-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Structural Genomics Consortium: Structure of the putative human dehydrogenase MGC4172 To be Published
1YO6	Crystal Structure of the putative Carbonyl Reductase Sniffer of Caenorhabditis elegans 分子名称: Putative Carbonyl Reductase Sniffer 著者 Southeast Collaboratory for Structural Genomics (SECSG) 登録日 2005-01-26 公開日 2005-02-15 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure of the putative Carbonyl Reductase Sniffer of Caenorhabditis elegans To be Published
1ZEM	Crystal Structure of NAD+-Bound Xylitol Dehydrogenase 分子名称: MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, xylitol dehydrogenase 著者 Ehrensberger, A.H, Elling, R.A, Wilson, D.K. 登録日 2005-04-19 公開日 2006-03-28 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-guided engineering of xylitol dehydrogenase cosubstrate specificity. Structure, 14, 2006
1ZBQ	Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD 分子名称: 17-beta-hydroxysteroid dehydrogenase 4, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Lukacik, P, Shafqat, N, Kavanagh, K, Bray, J, von Delft, F, Edwards, A, Arrowsmith, C, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2005-04-08 公開日 2005-04-26 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD To be Published
1XR3	Actinorhodin Polyketide Ketoreductase with NADP and the Inhibitor Isoniazid bound 分子名称: 4-(DIAZENYLCARBONYL)PYRIDINE, ACTINORHODIN POLYKETIDE KETOREDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Korman, T.P, Hill, J.A, Vu, T.N, Tsai, S.C. 登録日 2004-10-13 公開日 2005-09-27 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity. Biochemistry, 43, 2004
1XSE	Crystal Structure of Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1 分子名称: 11beta-hydroxysteroid dehydrogenase type 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Ogg, D, Elleby, B, Norstrom, C, Stefansson, K, Abrahmsen, L, Oppermann, U, Svensson, S. 登録日 2004-10-19 公開日 2004-11-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions J.Biol.Chem., 280, 2005

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