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1LCJ	SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL Descriptor: P56==LCK== TYROSINE KINASE, PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL Authors: Eck, M, Harrison, S. Deposit date: 1994-12-12 Release date: 1995-10-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature, 362, 1993
1JYU	Xray Structure of Grb2 SH2 Domain Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1JWO	Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK Descriptor: Csk Homologous Kinase Authors: Murthy, T.V.S, Webster, G.D. Deposit date: 2001-09-04 Release date: 2001-09-12 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase To be Published
1LKL	HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY (PYEEG PEPTIDE) Descriptor: HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY Authors: Tong, L. Deposit date: 1995-11-10 Release date: 1996-03-08 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. J.Mol.Biol., 256, 1996
1LUI	NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.M. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUK	NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUN	NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
2AUG	Crystal structure of the Grb14 SH2 domain Descriptor: Growth factor receptor-bound protein 14 Authors: Depetris, R.S, Hu, J, Gimpelevich, I, Holt, L.J, Daly, R.J, Hubbard, S.R. Deposit date: 2005-08-27 Release date: 2005-11-01 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for inhibition of the insulin receptor by the adaptor protein grb14. Mol.Cell, 20, 2005
2CI8	sh2 domain of human nck1 adaptor protein - uncomplexed Descriptor: CYTOPLASMIC PROTEIN NCK1, PENTAETHYLENE GLYCOL, SULFATE ION Authors: Frese, S, Schubert, W.-D, Findeis, A.C, Marquardt, T, Roske, Y.S, Stradal, T.E.B, Heinz, D.W. Deposit date: 2006-03-17 Release date: 2006-04-24 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains. J.Biol.Chem., 281, 2006
2BBU	solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor Descriptor: GP130 PHOSPHOPEPTIDE, Suppressor of cytokine signaling 3 Authors: Babon, J.J, Yao, S, Norton, R.S. Deposit date: 2005-10-17 Release date: 2006-05-02 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: The Structure of SOCS3 Reveals the Basis of the Extended SH2 Domain Function and Identifies an Unstructured Insertion That Regulates Stability Mol.Cell, 22, 2006
2CR4	Solution structure of the SH2 domain of human SH3BP2 protein Descriptor: SH3 domain-binding protein 2 Authors: Hatta, R, Tomizawa, T, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-20 Release date: 2005-11-20 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the SH2 domain of human SH3BP2 protein To be Published
1ZFP	GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PENTAPEPTIDE Descriptor: EPIDERMAL GROWTH FACTOR RECEPTOR-DERIVED PEPTIDE, GROWTH FACTOR RECEPTOR BINDING PROTEIN, ZINC ION Authors: Rahuel, J. Deposit date: 1998-03-26 Release date: 1999-03-30 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands. J.Mol.Biol., 279, 1998
2AOA	Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain Descriptor: 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Growth factor receptor-bound protein 2 Authors: Phan, J, Shi, Z.D, Burke, T.R, Waugh, D.S. Deposit date: 2005-08-12 Release date: 2005-10-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain. J.Mol.Biol., 353, 2005
2CIA	human nck2 sh2-domain in complex with a decaphosphopeptide from translocated intimin receptor (tir) of epec Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CYTOPLASMIC PROTEIN NCK2, ISOPROPYL ALCOHOL, ... Authors: Frese, S, Schubert, W.-D, Findeis, A.C, Marquardt, T, Roske, Y.S, Stradal, T.E.B, Heinz, D.W. Deposit date: 2006-03-17 Release date: 2006-04-24 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.45 Å) Cite: The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains. J.Biol.Chem., 281, 2006
2CI9	Nck1 SH2-domain in complex with a dodecaphosphopeptide from EPEC protein Tir Descriptor: CYTOPLASMIC PROTEIN NCK1, TRANSLOCATED INTIMIN RECEPTOR Authors: Frese, S, Schubert, W.-D, Findeis, A.C, Marquardt, T, Roske, Y.S, Stradal, T.E.B, Heinz, D.W. Deposit date: 2006-03-17 Release date: 2006-04-24 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains. J.Biol.Chem., 281, 2006
1Z3K	Structural Insight into the Binding Diversity between the Tyr-Phosphorylated Human EphrinBs and Nck2 SH2 Domain Descriptor: Cytoplasmic protein NCK2 Authors: Ran, X, Song, J. Deposit date: 2005-03-14 Release date: 2005-03-29 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain. J.Biol.Chem., 280, 2005
2DX0	Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2 Descriptor: Phospholipase C, gamma 2, SULFATE ION Authors: Handa, N, Takagi, T, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-08-22 Release date: 2007-09-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2 To be Published
2DM0	Solution structure of the SH2 domain of human Tyrosine-protein kinase TXK Descriptor: Tyrosine-protein kinase TXK Authors: Endo, H, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-04-20 Release date: 2006-10-20 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the SH2 domain of human Tyrosine-protein kinase TXK To be Published
2DLZ	Solution structure of the SH2 domain of human protein vav-2 Descriptor: Protein vav-2 Authors: Endo, H, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-04-20 Release date: 2007-04-03 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the SH2 domain of human protein vav-2 To be Published
2AOB	Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain Descriptor: 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID, Growth factor receptor-bound protein 2 Authors: Phan, J, Shi, Z.D, Burke, T.R, Waugh, D.S. Deposit date: 2005-08-12 Release date: 2005-10-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain. J.Mol.Biol., 353, 2005
2CS0	Solution structure of the SH2 domain of human HSH2D protein Descriptor: Hematopoietic SH2 domain containing Authors: Kurosaki, C, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-20 Release date: 2005-11-20 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the SH2 domain of human HSH2D protein To be published
2CRH	Solution structure of the SH2 domain of human proto-oncogene protein VAV1 Descriptor: Vav proto-oncogene Authors: Endo, H, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-20 Release date: 2005-11-20 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the SH2 domain of human proto-oncogene protein VAV1 to be published
2DLY	Solution structure of the SH2 domain of murine Fyn-related kinase Descriptor: Fyn-related kinase Authors: Endo, H, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-04-20 Release date: 2006-10-20 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the SH2 domain of murine Fyn-related kinase To be Published
2DCR	Fully automated solution structure determination of the Fes SH2 domain Descriptor: Proto-oncogene tyrosine-protein kinase Fes/Fps Authors: Lopez-Mendez, B, Guntert, P. Deposit date: 2006-01-12 Release date: 2006-10-17 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Automated protein structure determination from NMR spectra J.AM.CHEM.SOC., 128, 2006
1A1A	C-SRC (SH2 DOMAIN WITH C188A MUTATION) COMPLEXED WITH ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE) Descriptor: ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE Authors: Shewchuk, L, Jordan, S. Deposit date: 1997-12-10 Release date: 1998-04-08 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2 Å) Cite: Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997

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