2BBU

solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor

Summary for 2BBU

• Entry DOI: 10.2210/pdb2bbu/pdb
• NMR Information: BMRB: 6580
• Descriptor: Suppressor of cytokine signaling 3, GP130 PHOSPHOPEPTIDE (2 entities in total)
• Functional Keywords: sh2 domain, extended sh2 subdomain, pest motif, protein complex, phosphopeptide, cytokine regulator
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 19566.81

Authors

Babon, J.J.,Yao, S.,Norton, R.S. (deposition date: 2005-10-17, release date: 2006-05-02, Last modification date: 2022-03-09)

• Primary citation: Babon, J.J.,McManus, E.J.,Yao, S.,DeSouza, D.P.,Mielke, L.A.,Sprigg, N.S.,Willson, T.A.,Hilton, D.J.,Nicola, N.A.,Baca, M.,Nicholson, S.E.,Norton, R.S.; The Structure of SOCS3 Reveals the Basis of the Extended SH2 Domain Function and Identifies an Unstructured Insertion That Regulates Stability; Mol.Cell, 22:205-216, 2006; PubMed: 16630890; DOI: 10.1016/j.molcel.2006.03.024

Experimental method

SOLUTION NMR