7FIN
| Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GIPR-Gs complex | 分子名称: | CHOLESTEROL, GAMMA-L-GLUTAMIC ACID, Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor, ... | 著者 | Zhao, F.h, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | 登録日 | 2021-07-31 | 公開日 | 2022-02-23 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022
|
|
7FIY
| Cryo-EM structure of the tirzepatide-bound human GIPR-Gs complex | 分子名称: | CHOLESTEROL, Gastric inhibitory polypeptide receptor,Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | 登録日 | 2021-08-01 | 公開日 | 2022-03-02 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022
|
|
7FIM
| Cryo-EM structure of the tirzepatide (LY3298176)-bound human GLP-1R-Gs complex | 分子名称: | Glucagon-like peptide 1 receptor,Glucagon-like peptide 1 receptor,Glucagon-like peptide 1 receptor,Glucagon-like peptide 1 receptor,human glucagon like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | 登録日 | 2021-07-31 | 公開日 | 2022-03-02 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022
|
|
7EQ1
| GPR114-Gs-scFv16 complex | 分子名称: | Adhesion G-protein coupled receptor G5, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ping, Y. | 登録日 | 2021-04-28 | 公開日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for the tethered peptide activation of adhesion GPCRs. Nature, 604, 2022
|
|
7EPT
| Structural basis for the tethered peptide activation of adhesion GPCRs | 分子名称: | Adhesion G-protein coupled receptor D1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Ping, Y.-Q, Xiao, P, Yang, F, Zhao, R.-J, Guo, S.-C, Yan, X, Wu, X, Liebscher, I, Xu, H.E, Sun, J.-P. | 登録日 | 2021-04-27 | 公開日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for the tethered peptide activation of adhesion GPCRs. Nature, 604, 2022
|
|
7EUO
| The structure of formyl peptide receptor 1 in complex with Gi and peptide agonist fMLF | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, X.K, Chen, G, Liao, Q.W, Du, Y, Hu, H.L, Ye, D.Q. | 登録日 | 2021-05-18 | 公開日 | 2022-05-25 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns. Nat Commun, 13, 2022
|
|
7F0T
| |
7F1Z
| |
7F1O
| |
7F23
| |
7F24
| |
7F6G
| Cryo-EM structure of human angiotensin receptor AT1R in complex Gq proteins and Sar1-AngII | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin receptor AT1R, CHOLESTEROL, ... | 著者 | Zhang, D, Xu, L, Zhan, Y, Guo, J, Zhang, H. | 登録日 | 2021-06-25 | 公開日 | 2023-03-29 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists. Embo J., 42, 2023
|
|
7JJO
| Structural Basis of the Activation of Heterotrimeric Gs-protein by Isoproterenol-bound Beta1-Adrenergic Receptor | 分子名称: | Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Su, M, Zhu, L, Zhang, Y, Paknejad, N, Dey, R, Huang, J, Lee, M.Y, Williams, D, Jordan, K.D, Eng, E.T, Ernst, O.P, Meyerson, J.R, Hite, R.K, Walz, T, Liu, W, Huang, X.Y. | 登録日 | 2020-07-27 | 公開日 | 2020-09-02 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound beta 1 -Adrenergic Receptor. Mol.Cell, 80, 2020
|
|
7JOZ
| Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist | 分子名称: | 6-{4-[(furo[3,2-c]pyridin-4-yl)oxy]-2-methylphenyl}-1,5-dimethylpyrimidine-2,4(1H,3H)-dione, Endolysin,D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Sun, B, Feng, D, Chu, M.L, Fish, I, Kelm, S, Lebon, F, Lovera, S, Valade, A, Wood, M, Ceska, T, Kobilka, T.S, Sands, Z, Kobilka, B.K. | 登録日 | 2020-08-07 | 公開日 | 2021-04-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist. Nat Commun, 12, 2021
|
|
7JHJ
| Structure of the Epstein-Barr virus GPCR BILF1 in complex with human Gi | 分子名称: | Antibody fragment scFv16, BILF1, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Tsutsumi, N, Qu, Q.H, Skiniotis, G, Garcia, K.C. | 登録日 | 2020-07-20 | 公開日 | 2021-07-07 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1. Immunity, 54, 2021
|
|
8G59
| Cryo-EM structure of the TUG891 bound GPR120-Giq complex | 分子名称: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-08 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
|
|
8FN1
| CryoEM structure of Go-coupled NTSR1 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | 著者 | Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. | 登録日 | 2022-12-26 | 公開日 | 2023-03-29 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
|
|
8FMZ
| Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, MiniGq, ... | 著者 | Krumm, B.E, Diberto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. | 登録日 | 2022-12-26 | 公開日 | 2023-03-29 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | 主引用文献 | Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
|
|
8FN0
| CryoEM structure of Go-coupled NTSR1 with a biased allosteric modulator | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. | 登録日 | 2022-12-26 | 公開日 | 2023-03-29 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
|
|
8FU6
| GCGR-Gs complex in the presence of RAMP2 | 分子名称: | Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Krishna Kumar, K, O'Brien, E.S, Wang, H, Montabana, E, Kobilka, B.K. | 登録日 | 2023-01-16 | 公開日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Negative allosteric modulation of the glucagon receptor by RAMP2. Cell, 186, 2023
|
|
8G94
| Structure of CD69-bound S1PR1 coupled to heterotrimeric Gi | 分子名称: | Early activation antigen CD69, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Chen, H, Li, X. | 登録日 | 2023-02-21 | 公開日 | 2023-04-19 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Transmembrane protein CD69 acts as an S1PR1 agonist. Elife, 12, 2023
|
|
8FLR
| Human PTH1R in complex with PTHrP and Gs | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. | 登録日 | 2022-12-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
|
|
8FLQ
| Human PTH1R in complex with PTH(1-34) and Gs | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. | 登録日 | 2022-12-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | 主引用文献 | Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
|
|
8FLS
| Human PTH1R in complex with Abaloparatide and Gs | 分子名称: | Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. | 登録日 | 2022-12-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
|
|
8FLU
| Human PTH1R in complex with LA-PTH and Gs | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. | 登録日 | 2022-12-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
|
|