7W6N
| CryoEM structure of human KChIP1-Kv4.3 complex | 分子名称: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | 著者 | Ma, D.M, Guo, J.T. | 登録日 | 2021-12-02 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
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7XMG
| Cryo-EM structure of human NaV1.7/beta1/beta2-TCN-1752 | 分子名称: | (1~{Z})-~{N}-[2-methyl-3-[(~{E})-[6-[4-[[4-(trifluoromethyloxy)phenyl]methoxy]piperidin-1-yl]-1~{H}-1,3,5-triazin-2-ylidene]amino]phenyl]ethanimidic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jiang, D.H, Zhang, J.T. | 登録日 | 2022-04-25 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural basis for Na V 1.7 inhibition by pore blockers. Nat.Struct.Mol.Biol., 29, 2022
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7XM9
| Cryo-EM structure of human NaV1.7/beta1/beta2-XEN907 | 分子名称: | (7~{R})-1'-pentylspiro[6~{H}-furo[3,2-f][1,3]benzodioxole-7,3'-indole]-2'-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | zhang, J.T, Jiang, D.H. | 登録日 | 2022-04-25 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structural basis for Na V 1.7 inhibition by pore blockers. Nat.Struct.Mol.Biol., 29, 2022
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7YKS
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7YKR
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7XSU
| Cardiac sodium channel in complex with LqhIII | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-like toxin Lqh3, ... | 著者 | Jiang, D, Catterall, W.A. | 登録日 | 2022-05-15 | 公開日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural Basis for Nav1.5 Opening Modulated by a Gating Modifier Toxin To Be Published
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8S9C
| Cryo-EM structure of Nav1.7 with CBZ | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2023-03-27 | 公開日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8S9B
| Cryo-EM structure of Nav1.7 with LCM | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2023-03-27 | 公開日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8SDA
| CryoEM structure of rat Kv2.1(1-598) L403A mutant in nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1 | 著者 | Tan, X, Swartz, K.J. | 登録日 | 2023-04-06 | 公開日 | 2023-09-27 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Inactivation of the Kv2.1 channel through electromechanical coupling. Nature, 622, 2023
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8SD3
| CryoEM structure of rat Kv2.1(1-598) wild type in nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1 | 著者 | Tan, X, Swartz, K.J. | 登録日 | 2023-04-06 | 公開日 | 2023-09-27 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Inactivation of the Kv2.1 channel through electromechanical coupling. Nature, 622, 2023
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8T6L
| Cryo-EM structure of rat cardiac sodium channel NaV1.5 with batrachotoxin analog BTX-B | 分子名称: | (1R)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-9,12-dihydroxy-2,11a-dimethyl-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-7H-9,11b-epoxy-13a,5a-prop[1]enophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl benzoate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, ... | 著者 | Tonggu, L, Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | 登録日 | 2023-06-16 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin. Nat Commun, 15, 2024
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8SR8
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8SRB
| Cryo-EM structure of TRPM2 chanzyme in the presence of EDTA and ADP-ribose | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, TRPM2 chanzyme | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024
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8SRC
| Cryo-EM structure of TRPM2 chanzyme in the presence of Calcium and ADP-ribose | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, CHOLESTEROL, ... | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024
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8SR7
| Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate | 分子名称: | 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, CHOLESTEROL, ... | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (1.97 Å) | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024
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8SR9
| Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium | 分子名称: | CHOLESTEROL, MAGNESIUM ION, TRPM2 chanzyme | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024
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8SRA
| Cryo-EM structure of TRPM2 chanzyme in the presence of Calcium | 分子名称: | CALCIUM ION, CHOLESTEROL, TRPM2 chanzyme | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024
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8SRD
| Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, open state | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRI
| Cryo-EM structure of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, closed state | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRG
| Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate | 分子名称: | 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, CHOLESTEROL, ... | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRK
| Cryo-EM structure of TRPM2 chanzyme (without NUDT9-H domain) in the presence of Ca and ADP-ribose | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, CHOLESTEROL, ... | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRH
| Cryo-EM structure of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, open state | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.79 Å) | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRF
| Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, ADP-ribose, Adenosine monophosphate, and Ribose-5-phosphate, closed state | 分子名称: | 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, ... | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRJ
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8SRE
| Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, closed state | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | 登録日 | 2023-05-05 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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