8SR9

Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium

Summary for 8SR9

• Entry DOI: 10.2210/pdb8sr9/pdb
• EMDB information: 40723 40876
• Descriptor: TRPM2 chanzyme, MAGNESIUM ION, CHOLESTEROL (3 entities in total)
• Functional Keywords: trpm2 chanzyme, channel-enzyme, transport protein
• Biological source: Salpingoeca rosetta
• Total number of polymer chains: 4
• Total formula weight: 677844.22

Authors

Huang, Y.,Kumar, S.,Lu, W.,Du, J. (deposition date: 2023-05-05, release date: 2024-05-08, Last modification date: 2024-06-05)

• Primary citation: Huang, Y.,Kumar, S.,Lee, J.,Lu, W.,Du, J.; Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.; Nat.Struct.Mol.Biol., 2024; PubMed: 38773335; DOI: 10.1038/s41594-024-01316-4

Experimental method

ELECTRON MICROSCOPY (3.05 Å)