5HXH
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![BU of 5hxh by Molmil](/molmil-images/mine/5hxh) | Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with zero Na+ and Ca2+ | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, PENTADECANE, ... | Authors: | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | Deposit date: | 2016-01-30 | Release date: | 2016-05-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.804 Å) | Cite: | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger Nat.Struct.Mol.Biol., 23, 2016
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5JDF
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![BU of 5jdf by Molmil](/molmil-images/mine/5jdf) | Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 2.5 mM Na+ and 1mM Ca2+ | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, PENTADECANE, ... | Authors: | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | Deposit date: | 2016-04-16 | Release date: | 2016-05-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger. Nat.Struct.Mol.Biol., 23, 2016
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5A6E
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![BU of 5a6e by Molmil](/molmil-images/mine/5a6e) | Cryo-EM structure of the Slo2.2 Na-activated K channel | Descriptor: | GATING RING OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, PORE DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, RCK2 ELABORATION OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, ... | Authors: | Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R. | Deposit date: | 2015-06-25 | Release date: | 2015-10-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel Nature, 527, 2015
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5A6G
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![BU of 5a6g by Molmil](/molmil-images/mine/5a6g) | Cryo-EM structure of the Slo2.2 Na-activated K channel | Descriptor: | PORE DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, S1-S4 DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1 | Authors: | Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R. | Deposit date: | 2015-06-25 | Release date: | 2015-10-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel Nature, 527, 2015
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5A6F
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![BU of 5a6f by Molmil](/molmil-images/mine/5a6f) | Cryo-EM structure of the Slo2.2 Na-activated K channel | Descriptor: | GATING RING OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, RCK2 ELABORATION OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1 | Authors: | Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R. | Deposit date: | 2015-06-25 | Release date: | 2015-10-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel Nature, 527, 2015
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3QDZ
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![BU of 3qdz by Molmil](/molmil-images/mine/3qdz) | Crystal structure of the human thrombin mutant D102N in complex with the extracellular fragment of human PAR4. | Descriptor: | Proteinase-activated receptor 4, Thrombin heavy chain, Thrombin light chain | Authors: | Gandhi, P, Chen, Z, Appelbaum, E, Zapata, F, Di Cera, E. | Deposit date: | 2011-01-19 | Release date: | 2011-06-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis of thrombin-protease-receptor interactions IUBMB LIFE, 63, 2011
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4XPA
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![BU of 4xpa by Molmil](/molmil-images/mine/4xpa) | X-ray structure of Drosophila dopamine transporter bound to 3,4dichlorophenethylamine | Descriptor: | 2-(3,4-dichlorophenyl)ethanamine, Antibody fragment heavy chain-protein, 9D5-heavy chain, ... | Authors: | Aravind, P, Wang, K, Gouaux, E. | Deposit date: | 2015-01-16 | Release date: | 2015-05-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4BWZ
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![BU of 4bwz by Molmil](/molmil-images/mine/4bwz) | |
7DIX
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![BU of 7dix by Molmil](/molmil-images/mine/7dix) | Crystal structure of LeuT in lipidic cubic phase at pH 5 | Descriptor: | Na(+):neurotransmitter symporter (Snf family), SELENOMETHIONINE, SODIUM ION | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | Deposit date: | 2020-11-19 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.49 Å) | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
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5BZ2
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![BU of 5bz2 by Molmil](/molmil-images/mine/5bz2) | |
1JTW
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![BU of 1jtw by Molmil](/molmil-images/mine/1jtw) | |
7DJ1
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![BU of 7dj1 by Molmil](/molmil-images/mine/7dj1) | Crystal structure of the G26C mutant of LeuT | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | Deposit date: | 2020-11-19 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.528 Å) | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
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2M7X
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![BU of 2m7x by Molmil](/molmil-images/mine/2m7x) | Structural and Functional Analysis of Transmembrane Segment IV of the Salt Tolerance Protein Sod2 | Descriptor: | Na(+)/H(+) antiporter | Authors: | Ullah, A, Kemp, G, Lee, B, Alves, C, Young, H, Sykes, B.D, Fliegel, L. | Deposit date: | 2013-05-02 | Release date: | 2013-06-05 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and Functional Analysis of Transmembrane Segment IV of the Salt Tolerance Protein Sod2. J.Biol.Chem., 288, 2013
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7QHA
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![BU of 7qha by Molmil](/molmil-images/mine/7qha) | Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Photobacterium profundum in amphipol | Descriptor: | Megabody c7HopQ, Putative TRAP-type C4-dicarboxylate transport system, large permease component, ... | Authors: | North, R.A, Davies, J.S, Morado, D, Dobson, R.C.J. | Deposit date: | 2021-12-11 | Release date: | 2022-12-21 | Last modified: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter. Nat Commun, 14, 2023
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4D0A
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![BU of 4d0a by Molmil](/molmil-images/mine/4d0a) | |
4CZB
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![BU of 4czb by Molmil](/molmil-images/mine/4czb) | Structure of the sodium proton antiporter MjNhaP1 from Methanocaldococcus jannaschii at pH 8. | Descriptor: | NA(+)/H(+) ANTIPORTER 1, POTASSIUM ION, TRIS(HYDROXYETHYL)AMINOMETHANE | Authors: | Woehlert, D, Paulino, C, Kapotova, E, Kuhlbrandt, W, Yildiz, O. | Deposit date: | 2014-04-16 | Release date: | 2014-12-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | 3D Em Map of the Sodium Proton Antiporter Mjnhap1 from Methanocaldococcus Jannaschii Elife, 3, 2014
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6V1Q
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![BU of 6v1q by Molmil](/molmil-images/mine/6v1q) | Two-pore channel 3 | Descriptor: | SODIUM ION, Two pore channel 3 | Authors: | Dickinson, M.S, Stroud, R.M. | Deposit date: | 2019-11-20 | Release date: | 2019-12-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Resting state structure of the hyperdepolarization activated two-pore channel 3. Proc.Natl.Acad.Sci.USA, 117, 2020
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2KRG
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![BU of 2krg by Molmil](/molmil-images/mine/2krg) | Solution Structure of human sodium/ hydrogen exchange regulatory factor 1(150-358) | Descriptor: | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Authors: | Bhattacharya, S, Dai, Z, Li, J, Baxter, S, Callaway, D.J.E, Cowburn, D, Bu, Z. | Deposit date: | 2009-12-17 | Release date: | 2009-12-29 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation. J.Biol.Chem., 285, 2010
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3QS5
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![BU of 3qs5 by Molmil](/molmil-images/mine/3qs5) | |
3QS6
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![BU of 3qs6 by Molmil](/molmil-images/mine/3qs6) | |
3QS4
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![BU of 3qs4 by Molmil](/molmil-images/mine/3qs4) | |
8HB0
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![BU of 8hb0 by Molmil](/molmil-images/mine/8hb0) | Structure of human SGLT2-MAP17 complex with TA1887 | Descriptor: | (2R,3R,4S,5S,6R)-2-[3-[(4-cyclopropylphenyl)methyl]-4-fluoranyl-indol-1-yl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | Deposit date: | 2022-10-27 | Release date: | 2023-11-01 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat.Struct.Mol.Biol., 31, 2024
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8HDH
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![BU of 8hdh by Molmil](/molmil-images/mine/8hdh) | Structure of human SGLT2-MAP17 complex with Canagliflozin | Descriptor: | (2~{S},3~{R},4~{R},5~{S},6~{R})-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methyl-phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | Deposit date: | 2022-11-04 | Release date: | 2023-11-08 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat.Struct.Mol.Biol., 31, 2024
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8HG7
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![BU of 8hg7 by Molmil](/molmil-images/mine/8hg7) | Structure of human SGLT2-MAP17 complex with Sotagliflozin | Descriptor: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyl-oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | Deposit date: | 2022-11-14 | Release date: | 2023-11-15 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat.Struct.Mol.Biol., 31, 2024
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8HEZ
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![BU of 8hez by Molmil](/molmil-images/mine/8hez) | Structure of human SGLT2-MAP17 complex with Dapagliflozin | Descriptor: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | Deposit date: | 2022-11-09 | Release date: | 2023-11-15 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat.Struct.Mol.Biol., 31, 2024
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