4QXZ
 
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4RSS
 | | Crystal structure of tyrosine-protein kinase SYK with an inhibitor | | Descriptor: | 1-[(3-methyl-1-{2-[(1,2,3-trimethyl-1H-indol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol, Tyrosine-protein kinase SYK | | Authors: | Lee, B.I, Lee, S.J, Choi, J.-S. | | Deposit date: | 2014-11-11 | | Release date: | 2015-10-21 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
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4XGQ
 | | Crystal structure of addiction module from Mycobacterial species | | Descriptor: | Antitoxin VapB30, MAGNESIUM ION, Ribonuclease VapC30 | | Authors: | Lee, B.-J, Lee, I.-G, Lee, S.J. | | Deposit date: | 2015-01-02 | | Release date: | 2015-08-12 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides
Nucleic Acids Res., 43, 2015
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4XGR
 | | Crystal structure of addiction module from Mycobacterial species | | Descriptor: | Antitoxin VapB30, MAGNESIUM ION, Ribonuclease VapC30 | | Authors: | Lee, B.-J, Lee, I.-G, Lee, S.J. | | Deposit date: | 2015-01-02 | | Release date: | 2015-08-12 | | Last modified: | 2015-09-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides
Nucleic Acids Res., 43, 2015
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6ZZ6
 | | Cryo-EM structure of S.cerevisiae cohesin-Scc2-DNA complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (34-MER), MAGNESIUM ION, ... | | Authors: | Lee, B.-G, Gonzalez Llamazares, A, Collier, J, Nasmyth, K.A, Lowe, J. | | Deposit date: | 2020-08-04 | | Release date: | 2020-09-30 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3.
Elife, 9, 2020
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4Z1D
 | | Structure of PEP and zinc bound KDO8PS from H.pylori | | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHOENOLPYRUVATE, ZINC ION | | Authors: | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | | Deposit date: | 2015-03-27 | | Release date: | 2016-03-09 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
Eur.J.Med.Chem., 108, 2016
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4Z1C
 | | Structure of Cadmium bound KDO8PS from H.pylori | | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase, CADMIUM ION | | Authors: | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | | Deposit date: | 2015-03-27 | | Release date: | 2016-03-09 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
Eur.J.Med.Chem., 108, 2016
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4Z1A
 | | Structure of apo form KDO8PS from H.pylori | | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase | | Authors: | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | | Deposit date: | 2015-03-27 | | Release date: | 2016-03-09 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
Eur.J.Med.Chem., 108, 2016
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4Z1B
 | | Structure of H204A mutant KDO8PS from H.pylori | | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase | | Authors: | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | | Deposit date: | 2015-03-27 | | Release date: | 2016-03-09 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
Eur.J.Med.Chem., 108, 2016
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6YVV
 | | Condensin complex from S.cerevisiae ATP-free apo bridged state | | Descriptor: | Condensin complex subunit 1,Ycs4, Condensin complex subunit 2,Brn1, Structural maintenance of chromosomes protein 2,Structural maintenance of chromosomes protein 2, ... | | Authors: | Lee, B.-G, Cawood, C, Gutierrez-Escribano, P, Nakane, T, Merkel, F, Hassler, M, Haering, C.H, Aragon, L, Lowe, J. | | Deposit date: | 2020-04-28 | | Release date: | 2020-07-15 | | Last modified: | 2020-08-19 | | Method: | ELECTRON MICROSCOPY (7.5 Å) | | Cite: | Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism.
Nat.Struct.Mol.Biol., 27, 2020
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6YVU
 | | Condensin complex from S.cerevisiae ATP-free apo non-engaged state | | Descriptor: | Condensin complex subunit 1,Condensin complex subunit 1,Ycs4, Condensin complex subunit 2,Condensin complex subunit 2,Brn1, Structural maintenance of chromosomes protein 2,Structural maintenance of chromosomes protein 2,Smc2, ... | | Authors: | Lee, B.-G, Cawood, C, Gutierrez-Escribano, P, Nakane, T, Merkel, F, Hassler, M, Aragon, L, Haering, C.H, Lowe, J. | | Deposit date: | 2020-04-28 | | Release date: | 2020-07-15 | | Last modified: | 2020-08-19 | | Method: | ELECTRON MICROSCOPY (7.5 Å) | | Cite: | Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism.
Nat.Struct.Mol.Biol., 27, 2020
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7OGT
 | | Folded elbow of cohesin | | Descriptor: | Structural maintenance of chromosomes protein 1, Structural maintenance of chromosomes protein 3 | | Authors: | Lee, B.-G, Gonzalez Llamazares, A, Collier, J, Patele, N.J, Nasmyth, K.A, Lowe, J. | | Deposit date: | 2021-05-07 | | Release date: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes.
Elife, 10, 2021
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7P81
 | | Crystal structure of ClpP from Bacillus subtilis in complex with ADEP2 (compact state) | | Descriptor: | ADEP2, ATP-dependent Clp protease proteolytic subunit | | Authors: | Lee, B.-G, Kim, L, Kim, M.K, Kwon, D.H, Song, H.K. | | Deposit date: | 2021-07-21 | | Release date: | 2022-06-29 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Structural insights into ClpP protease side exit pore-opening by a pH drop coupled with substrate hydrolysis.
Embo J., 41, 2022
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7P80
 | | Crystal structure of ClpP from Bacillus subtilis in complex with ADEP2 (compressed state) | | Descriptor: | ADEP2, ATP-dependent Clp protease proteolytic subunit | | Authors: | Lee, B.-G, Kim, L, Kim, M.K, Kwon, D.H, Song, H.K. | | Deposit date: | 2021-07-21 | | Release date: | 2022-06-29 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Structural insights into ClpP protease side exit pore-opening by a pH drop coupled with substrate hydrolysis.
Embo J., 41, 2022
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7Q2Y
 | | Cryo-EM structure of clamped S.cerevisiae condensin-DNA complex (form II) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Condensin complex subunit 1, ... | | Authors: | Lee, B.-G, Rhodes, J, Lowe, J. | | Deposit date: | 2021-10-26 | | Release date: | 2022-03-23 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Clamping of DNA shuts the condensin neck gate.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7Q2X
 | | Cryo-EM structure of clamped S.cerevisiae condensin-DNA complex (Form I) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Condensin complex subunit 1, ... | | Authors: | Lee, B.-G, Rhodes, J, Lowe, J. | | Deposit date: | 2021-10-26 | | Release date: | 2022-03-23 | | Last modified: | 2022-04-13 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Clamping of DNA shuts the condensin neck gate.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7Q2Z
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4UF7
 | | Ghanaian henipavirus (Gh-M74a) attachment glycoprotein in complex with human ephrinB2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CHLORIDE ION, ... | | Authors: | Lee, B, Pernet, O, Ahmed, A.A, Zeltina, A, Beaty, S.M, Bowden, T.A. | | Deposit date: | 2015-03-13 | | Release date: | 2015-04-01 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Molecular Recognition of Human Ephrinb2 Cell Surface Receptor by an Emergent African Henipavirus.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4QJN
 | | Crystal structure of apo nucleoid associated protein, SAV1473 | | Descriptor: | DNA-binding protein HU | | Authors: | Lee, B.-J, Kim, D.-H, Im, H, Yoon, H.-J. | | Deposit date: | 2014-06-04 | | Release date: | 2014-12-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.613 Å) | | Cite: | beta-Arm flexibility of HU from Staphylococcus aureus dictates the DNA-binding and recognition mechanism
Acta Crystallogr.,Sect.D, 70, 2014
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4QJU
 | | Crystal structure of DNA-bound nucleoid associated protein, SAV1473 | | Descriptor: | DNA (5'-D(*TP*GP*CP*TP*TP*AP*TP*CP*AP*AP*TP*TP*TP*GP*TP*TP*GP*CP*AP*CP*C)-3'), DNA-binding protein HU | | Authors: | Lee, B.-J, Kim, D.-H, Im, H, Yoon, H.-J. | | Deposit date: | 2014-06-04 | | Release date: | 2014-12-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | beta-Arm flexibility of HU from Staphylococcus aureus dictates the DNA-binding and recognition mechanism
Acta Crystallogr.,Sect.D, 70, 2014
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5JV4
 | | Structure of F420 binding protein, MSMEG_6526, from Mycobacterium smegmatis with F420 bound | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, COENZYME F420, ... | | Authors: | Lee, B.M, Carr, P.D, Jackson, C.J. | | Deposit date: | 2016-05-10 | | Release date: | 2017-08-09 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of F420 binding protein, MSMEG_6526, from Mycobacterium smegmatis with F420 bound
To Be Published
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7VHV
 | | Crystal structure of S. aureus D-alanine alanyl carrier protein ligase | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, D-alanine--D-alanyl carrier protein ligase, MAGNESIUM ION | | Authors: | Lee, B.J, Lee, I.-G, Im, H.G, Yoon, H.J. | | Deposit date: | 2021-09-23 | | Release date: | 2022-04-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structural and functional analysis of the D-alanyl carrier protein ligase DltA from Staphylococcus aureus Mu50.
Acta Crystallogr D Struct Biol, 78, 2022
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8CTV
 | | Crystal structure of a K+ selective NaK mutant (NaK2K) -Tl+ complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein, SODIUM ION, ... | | Authors: | Lee, B, White, K.I, Socolich, M.A, Klureza, M.A, Henning, R, Srajer, V, Ranganathan, R, Hekstra, D. | | Deposit date: | 2022-05-16 | | Release date: | 2023-06-14 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Direct visualization of electric field-stimulated ion conduction in a potassium channel
To Be Published
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8CTT
 | | Crystal structure of a K+ selective NaK mutant (NaK2K) at 100K | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein | | Authors: | Lee, B, White, K.I, Socolich, M.A, Klureza, M.A, Henning, R, Srajer, V, Ranganathan, R, Hekstra, D. | | Deposit date: | 2022-05-16 | | Release date: | 2023-06-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Direct visualization of electric field-stimulated ion conduction in a potassium channel
To Be Published
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3CNK
 | | Crystal Structure of the dimerization domain of human filamin A | | Descriptor: | Filamin-A, SULFATE ION | | Authors: | Lee, B.J, Seo, M.D, Seok, S.H, Lee, S.J, Kwon, A.R, Im, H. | | Deposit date: | 2008-03-26 | | Release date: | 2009-02-10 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal structure of the dimerization domain of human filamin A
Proteins, 75, 2008
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