4V8Y
| Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | Descriptor: | 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ... | Authors: | Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W. | Deposit date: | 2013-07-20 | Release date: | 2014-07-09 | Last modified: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Molecular architecture of a eukaryotic translational initiation complex. Science, 342, 2013
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4V91
| Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES | Descriptor: | 25S RRNA, 5.8S RRNA, 5S RRNA, ... | Authors: | Fernandez, I.S, Bai, X, Scheres, S.H.W, Ramakrishnan, V. | Deposit date: | 2014-03-21 | Release date: | 2014-07-09 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Initiation of Translation by Cricket Paralysis Virus Ires Requires its Translocation in the Ribosome. Cell(Cambridge,Mass.), 157, 2014
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9EOG
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9EOH
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4V8Z
| Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | Descriptor: | 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ... | Authors: | Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W. | Deposit date: | 2013-07-20 | Release date: | 2014-07-09 | Last modified: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Molecular architecture of a eukaryotic translational initiation complex. Science, 342, 2013
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4V92
| Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES | Descriptor: | 18S RRNA, ES1, ES10, ... | Authors: | Fernandez, I.S, Bai, X, Scheres, S.H.W, Ramakrishnan, V. | Deposit date: | 2014-03-21 | Release date: | 2014-07-09 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Initiation of Translation by Cricket Paralysis Virus Ires Requires its Translocation in the Ribosome. Cell(Cambridge,Mass.), 157, 2014
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5A63
| Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Bai, X, Yan, C, Yang, G, Lu, P, Ma, D, Sun, L, Zhou, R, Scheres, S.H.W, Shi, Y. | Deposit date: | 2015-06-24 | Release date: | 2015-08-05 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | An Atomic Structure of Human Gamma-Secretase Nature, 525, 2015
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5UMD
| Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Wong, W, Bai, X.-C, Brown, A, Scheres, S, Baum, J. | Deposit date: | 2017-01-27 | Release date: | 2017-03-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Nat Microbiol, 2, 2017
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5M1S
| Cryo-EM structure of the E. coli replicative DNA polymerase-clamp-exonuclase-theta complex bound to DNA in the editing mode | Descriptor: | DNA Primer Strand, DNA Template Strand, DNA polymerase III subunit alpha, ... | Authors: | Fernandez-Leiro, R, Conrad, J, Scheres, S.H.W, Lamers, M.H. | Deposit date: | 2016-10-10 | Release date: | 2017-01-18 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (6.7 Å) | Cite: | Self-correcting mismatches during high-fidelity DNA replication. Nat. Struct. Mol. Biol., 24, 2017
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8CAQ
| Structure of Tau filaments Type I from Subacute Sclerosing Panencephalitis | Descriptor: | Microtubule-associated protein tau | Authors: | Qi, C, Hasegawa, M, Takao, M, Sakai, M, Akagi, M, Iwasaki, Y, Yoshida, M, Scheres, S.H.W, Goedert, M. | Deposit date: | 2023-01-24 | Release date: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy. Acta Neuropathol Commun, 11, 2023
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8CAX
| Structure of Tau filaments Type II from Subacute Sclerosing Panencephalitis | Descriptor: | Microtubule-associated protein tau | Authors: | Qi, C, Hasegawa, M, Takao, M, Sakai, M, Akagi, M, Iwasaki, Y, Yoshida, M, Scheres, S.H.W, Goedert, M. | Deposit date: | 2023-01-24 | Release date: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy. Acta Neuropathol Commun, 11, 2023
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4V5X
| The cryo-EM structure of a 3D DNA-origami object | Descriptor: | SCAFFOLD STRAND,SCAFFOLD STRAND, STAPLE STRAND | Authors: | Bai, X.C, Martin, T.G, Scheres, S.H.W, Dietz, H. | Deposit date: | 2012-10-09 | Release date: | 2014-07-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (11.5 Å) | Cite: | Cryo-Em Structure of a 3D DNA-Origami Object. Proc.Natl.Acad.Sci.USA, 109, 2012
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6QJP
| Cryo-EM structure of heparin-induced 2N4R tau jagged filaments | Descriptor: | Microtubule-associated protein tau | Authors: | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2019-01-24 | Release date: | 2019-02-20 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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6QJH
| Cryo-EM structure of heparin-induced 2N4R tau snake filaments | Descriptor: | Microtubule-associated protein tau | Authors: | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2019-01-24 | Release date: | 2019-02-20 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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6QJM
| Cryo-EM structure of heparin-induced 2N4R tau twister filaments | Descriptor: | Microtubule-associated protein tau | Authors: | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2019-01-24 | Release date: | 2019-02-27 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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6QJQ
| Cryo-EM structure of heparin-induced 2N3R tau filaments | Descriptor: | Microtubule-associated protein tau | Authors: | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2019-01-24 | Release date: | 2019-02-20 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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6RZA
| Cryo-EM structure of the human inner arm dynein DNAH7 microtubule binding domain bound to microtubules | Descriptor: | Cytoplasmic dynein 1 heavy chain 1,Dynein heavy chain 7, axonemal,Cytoplasmic dynein 1 heavy chain 1, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Lacey, S.E, He, S, Scheres, S.H.W, Carter, A.P. | Deposit date: | 2019-06-13 | Release date: | 2019-07-10 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule. Elife, 8, 2019
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6GX5
| Narrow Pick Filament from Pick's disease brain | Descriptor: | Microtubule-associated protein tau | Authors: | Falcon, B, Zhang, W, Murzin, A.G, Murshudov, G, Garringer, H.J, Vidal, R, Crowther, R.A, Ghetti, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2018-06-26 | Release date: | 2018-09-12 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of filaments from Pick's disease reveal a novel tau protein fold. Nature, 561, 2018
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6HRF
| Straight filament from sporadic Alzheimer's disease brain | Descriptor: | Microtubule-associated protein tau | Authors: | Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2018-09-26 | Release date: | 2018-10-10 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta Neuropathol., 136, 2018
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6HRE
| Paired helical filament from sporadic Alzheimer's disease brain | Descriptor: | Microtubule-associated protein tau | Authors: | Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2018-09-26 | Release date: | 2018-10-10 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta Neuropathol., 136, 2018
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6RZB
| Cryo-EM structure of mouse cytoplasmic dynein-1 microtubule binding domain bound to microtubules | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Lacey, S.E, He, S, Scheres, S.H.W, Carter, A.P. | Deposit date: | 2019-06-13 | Release date: | 2019-07-10 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule. Elife, 8, 2019
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6OKK
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7Q4M
| Type II beta-amyloid 42 Filaments from Human Brain | Descriptor: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | Authors: | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-11-01 | Release date: | 2021-11-24 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
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7Q4B
| Type I beta-amyloid 42 Filaments from Human Brain | Descriptor: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | Authors: | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-10-30 | Release date: | 2021-11-24 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
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6SRS
| Structure of the Fanconi anaemia core subcomplex | Descriptor: | Fanconi anaemia protein FANCL, Unassigned secondary structure elements (central region, proposed FANCB-FAAP100), ... | Authors: | Shakeel, S, Rajendra, E, Alcon, P, He, S, Scheres, S.H.W, Passmore, L.A. | Deposit date: | 2019-09-05 | Release date: | 2019-11-06 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structure of the Fanconi anaemia monoubiquitin ligase complex. Nature, 575, 2019
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