8A9L
 
 | | Cryo-EM structure of alpha-synuclein filaments from Parkinson's disease and dementia with Lewy bodies | | Descriptor: | Alpha-synuclein, Unknown fragment | | Authors: | Yang, Y, Shi, Y, Schweighauser, M, Zhang, X.J, Kotecha, A, Murzin, A.G, Garringer, H.J, Cullinane, P, Saito, Y, Foroud, T, Warner, T.T, Hasegawa, K, Vidal, R, Murayama, S, Revesz, T, Ghetti, B, Hasegawa, M, Lashley, T, Scheres, H.W.S, Goedert, M. | | Deposit date: | 2022-06-28 | | Release date: | 2022-08-31 | | Last modified: | 2022-11-09 | | Method: | ELECTRON MICROSCOPY (2.16 Å) | | Cite: | Structures of alpha-synuclein filaments from human brains with Lewy pathology.
Nature, 610, 2022
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6HRF
 | | Straight filament from sporadic Alzheimer's disease brain | | Descriptor: | Microtubule-associated protein tau | | Authors: | Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2018-09-26 | | Release date: | 2018-10-10 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Acta Neuropathol., 136, 2018
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6GX5
 | | Narrow Pick Filament from Pick's disease brain | | Descriptor: | Microtubule-associated protein tau | | Authors: | Falcon, B, Zhang, W, Murzin, A.G, Murshudov, G, Garringer, H.J, Vidal, R, Crowther, R.A, Ghetti, B, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2018-06-26 | | Release date: | 2018-09-12 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures of filaments from Pick's disease reveal a novel tau protein fold.
Nature, 561, 2018
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6HRE
 | | Paired helical filament from sporadic Alzheimer's disease brain | | Descriptor: | Microtubule-associated protein tau | | Authors: | Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2018-09-26 | | Release date: | 2018-10-10 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Acta Neuropathol., 136, 2018
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6XYO
 | | Multiple system atrophy Type I alpha-synuclein filament | | Descriptor: | Alpha-synuclein | | Authors: | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2020-01-30 | | Release date: | 2020-02-12 | | Last modified: | 2020-09-30 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
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6XYP
 | | Multiple system atrophy Type II-1 alpha-synuclein filament | | Descriptor: | Alpha-synuclein | | Authors: | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2020-01-30 | | Release date: | 2020-02-12 | | Last modified: | 2020-09-30 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
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6XYQ
 | | Multiple system atrophy Type II-2 alpha-synuclein filament | | Descriptor: | Alpha-synuclein | | Authors: | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2020-01-30 | | Release date: | 2020-02-12 | | Last modified: | 2020-09-30 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
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7Q4B
 | | Type I beta-amyloid 42 Filaments from Human Brain | | Descriptor: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | | Authors: | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2021-10-30 | | Release date: | 2021-11-24 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
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7Q4M
 | | Type II beta-amyloid 42 Filaments from Human Brain | | Descriptor: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | | Authors: | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2021-11-01 | | Release date: | 2021-11-24 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
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5O3L
 | | Paired helical filament in Alzheimer's disease brain | | Descriptor: | Microtubule-associated protein tau | | Authors: | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2017-05-24 | | Release date: | 2017-07-26 | | Last modified: | 2019-07-24 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease.
Nature, 547, 2017
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5O3O
 | | Pronase-treated paired helical filament in Alzheimer's disease brain | | Descriptor: | Microtubule-associated protein tau | | Authors: | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2017-05-24 | | Release date: | 2017-07-26 | | Last modified: | 2017-08-02 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease.
Nature, 547, 2017
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5O3T
 | | Straight filament in Alzheimer's disease brain | | Descriptor: | Microtubule-associated protein tau | | Authors: | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2017-05-24 | | Release date: | 2017-07-26 | | Last modified: | 2017-08-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease.
Nature, 547, 2017
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8QN6
 | | Amyloid-beta 40 type 2 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy | | Descriptor: | Amyloid-beta A4 protein | | Authors: | Yang, Y, Murzin, A.S, Peak-Chew, S.Y, Franco, C, Newell, K.L, Ghetti, B, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2023-09-25 | | Release date: | 2023-12-13 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy.
Acta Neuropathol Commun, 11, 2023
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6NWP
 | | Chronic traumatic encephalopathy Type I Tau filament | | Descriptor: | Microtubule-associated protein tau | | Authors: | Falcon, B, Zivanov, J, Zhang, W, Murzin, A.G, Garringer, H.J, Vidal, R, Crowther, R.A, Newell, K.L, Ghetti, B, Goedert, M, Scheres, H.W. | | Deposit date: | 2019-02-07 | | Release date: | 2019-03-27 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Nature, 568, 2019
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6NWQ
 | | Chronic traumatic encephalopathy Type II Tau filament | | Descriptor: | Microtubule-associated protein tau | | Authors: | Falcon, B, Zivanov, J, Zhang, W, Murzin, A.G, Garringer, H.J, Vidal, R, Crowther, R.A, Newell, K.L, Ghetti, B, Goedert, M, Scheres, H.W. | | Deposit date: | 2019-02-07 | | Release date: | 2019-03-27 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Nature, 568, 2019
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8P34
 | | Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT | | Descriptor: | Microtubule-associated protein tau | | Authors: | Schweighauser, M, Garringer, H.J, Klingstedt, T, Masuda-Suzukake, M, Murrell, J.R, Vidal, R, Scheres, S.H.W, Goedert, M, Ghetti, B, Newell, K.L. | | Deposit date: | 2023-05-17 | | Release date: | 2023-07-05 | | Last modified: | 2023-07-19 | | Method: | ELECTRON MICROSCOPY (2.61 Å) | | Cite: | Mutation ∆K281 in MAPT causes Pick's disease.
Acta Neuropathol, 146, 2023
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8QN7
 | | Amyloid-beta 40 type 1 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy | | Descriptor: | Amyloid-beta A4 protein | | Authors: | Yang, Y, Murzin, A.S, Peak-Chew, S.Y, Franco, C, Newell, K.L, Ghetti, B, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2023-09-25 | | Release date: | 2023-12-13 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy.
Acta Neuropathol Commun, 11, 2023
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8BQW
 | | Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy | | Descriptor: | Alpha-synuclein, Unknown protein | | Authors: | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | | Deposit date: | 2023-01-18 | | Release date: | 2023-02-22 | | Last modified: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
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8BYN
 | | Chronic traumatic encephalopathy tau filaments with PET ligand flortaucipir | | Descriptor: | 7-(6-fluoranylpyridin-3-yl)-5~{H}-pyrido[4,3-b]indole, Microtubule-associated protein tau | | Authors: | Shi, Y, Ghetti, B, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2022-12-13 | | Release date: | 2023-01-11 | | Last modified: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir.
J.Mol.Biol., 435, 2023
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8BG0
 | | Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40 | | Descriptor: | Amyloid-beta precursor protein | | Authors: | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2022-10-27 | | Release date: | 2023-01-18 | | Last modified: | 2023-02-22 | | Method: | ELECTRON MICROSCOPY (1.9 Å) | | Cite: | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains.
Acta Neuropathol, 145, 2023
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8BQV
 | | Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy | | Descriptor: | Alpha-synuclein, Unknown protein | | Authors: | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | | Deposit date: | 2023-01-18 | | Release date: | 2023-02-22 | | Last modified: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (2 Å) | | Cite: | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
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8CEB
 | | Type2 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein | | Descriptor: | Alpha-synuclein | | Authors: | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Sew, P.C, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | | Deposit date: | 2023-02-01 | | Release date: | 2023-03-08 | | Last modified: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
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8CE7
 | | Type1 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein | | Descriptor: | Alpha-synuclein | | Authors: | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | | Deposit date: | 2023-02-01 | | Release date: | 2023-03-01 | | Last modified: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
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8BFZ
 | | Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42 | | Descriptor: | Amyloid-beta precursor protein | | Authors: | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordberg, A, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2022-10-27 | | Release date: | 2023-01-18 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains.
Acta Neuropathol, 145, 2023
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8BG9
 | | Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta | | Descriptor: | Amyloid-beta protein 40 | | Authors: | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2022-10-27 | | Release date: | 2023-01-18 | | Last modified: | 2023-02-22 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains.
Acta Neuropathol, 145, 2023
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