7Q4M

Type II beta-amyloid 42 Filaments from Human Brain

Summary for 7Q4M

• Entry DOI: 10.2210/pdb7q4m/pdb
• EMDB information: 13809
• Descriptor: Amyloid-beta precursor protein, UNKNOWN ATOM OR ION (2 entities in total)
• Functional Keywords: amyloid filaments, abeta42, human brain, cryo-em, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 10
• Total formula weight: 45200.87

Authors

Yang, Y.,Arseni, D.,Zhang, W.,Huang, M.,Lovestam, S.K.A.,Schweighauser, M.,Kotecha, A.,Murzin, A.G.,Peak-Chew, S.Y.,Macdonald, J.,Lavenir, I.,Garringer, H.J.,Gelpi, E.,Newell, K.L.,Kovacs, G.G.,Vidal, R.,Ghetti, B.,Falcon, B.,Scheres, S.H.W.,Goedert, M. (deposition date: 2021-11-01, release date: 2021-11-24, Last modification date: 2023-03-08)

• Primary citation: Yang, Y.,Arseni, D.,Zhang, W.,Huang, M.,Lovestam, S.,Schweighauser, M.,Kotecha, A.,Murzin, A.G.,Peak-Chew, S.Y.,Macdonald, J.,Lavenir, I.,Garringer, H.J.,Gelpi, E.,Newell, K.L.,Kovacs, G.G.,Vidal, R.,Ghetti, B.,Ryskeldi-Falcon, B.,Scheres, S.H.W.,Goedert, M.; Cryo-EM structures of amyloid-beta 42 filaments from human brains.; Science, 375:167-172, 2022; PubMed: 35025654; DOI: 10.1126/science.abm7285

Experimental method

ELECTRON MICROSCOPY (2.8 Å)