1J4I
| crystal structure analysis of the FKBP12 complexed with 000308 small molecule | Descriptor: | 4-METHYL-2-{[4-(TOLUENE-4-SULFONYL)-THIOMORPHOLINE-3-CARBONYL]-AMINO}-PENTANOIC ACID, FKBP12 | Authors: | Li, P, Ding, Y, Wang, L, Wu, B, Shu, C, Li, S, Shen, B, Rao, Z. | Deposit date: | 2001-09-30 | Release date: | 2003-06-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Design and structure-based study of new potential FKBP12 inhibitors. Biophys.J., 85, 2003
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1J4H
| crystal structure analysis of the FKBP12 complexed with 000107 small molecule | Descriptor: | 3-PHENYL-2-{[4-(TOLUENE-4-SULFONYL)-THIOMORPHOLINE-3-CARBONYL]-AMINO}-PROPIONIC ACID ETHYL ESTER, FKBP12 | Authors: | Li, P, Ding, Y, Wang, L, Wu, B, Shu, C, Li, S, Shen, B, Rao, Z. | Deposit date: | 2001-09-30 | Release date: | 2003-06-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Design and structure-based study of new potential FKBP12 inhibitors. Biophys.J., 85, 2003
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7OP5
| Cryo-EM structure of P5B-ATPase E2P | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, P5B-ATPase | Authors: | Li, P, Gourdon, P. | Deposit date: | 2021-05-29 | Release date: | 2021-06-30 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure and transport mechanism of P5B-ATPases. Nat Commun, 12, 2021
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7OP1
| Cryo-EM structure of P5B-ATPase E2PiAlF/SPM | Descriptor: | Cation-transporting ATPase, MAGNESIUM ION, SPERMINE, ... | Authors: | Li, P, Gourdon, P. | Deposit date: | 2021-05-28 | Release date: | 2021-06-30 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure and transport mechanism of P5B-ATPases. Nat Commun, 12, 2021
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7OP8
| Cryo-EM structure of P5B-ATPase E2Pinhibit | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Cation-transporting ATPase, MAGNESIUM ION | Authors: | Li, P, Gourdon, P. | Deposit date: | 2021-05-31 | Release date: | 2021-06-30 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure and transport mechanism of P5B-ATPases. Nat Commun, 12, 2021
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7OP3
| Cryo-EM structure of P5B-ATPase E2PiSPM | Descriptor: | Cation-transporting ATPase, SPERMINE | Authors: | Li, P, Gronberg, C, Wang, K.T, Salustros, N, Gourdon, P.E. | Deposit date: | 2021-05-28 | Release date: | 2021-06-30 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure and transport mechanism of P5B-ATPases. Nat Commun, 12, 2021
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7EOD
| MITF HLHLZ Delta AKE | Descriptor: | GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor | Authors: | Li, P, Liu, Z, Fang, P, Wang, J. | Deposit date: | 2021-04-22 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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1HYR
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7PRU
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7PSD
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7PRO
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7PQX
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7PR1
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7PGE
| copper transporter PcoB | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, Copper resistance protein B, LAURYL DIMETHYLAMINE-N-OXIDE, ... | Authors: | Li, P, Gourdon, P.E. | Deposit date: | 2021-08-13 | Release date: | 2022-07-06 | Last modified: | 2022-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | PcoB is a defense outer membrane protein that facilitates cellular uptake of copper. Protein Sci., 31, 2022
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2GSG
| Crystal structure of the Fv fragment of a monoclonal antibody specific for poly-glutamine | Descriptor: | SULFATE ION, monoclonal antibody heavy chain, monoclonal antibody light chain | Authors: | Li, P, Huey-Tubman, K.E, West Jr, A.P, Bennett, M.J, Bjorkman, P.J. | Deposit date: | 2006-04-26 | Release date: | 2007-04-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The structure of a polyQ-anti-polyQ complex reveals binding according to a linear lattice model. Nat.Struct.Mol.Biol., 14, 2007
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6O8C
| Crystal structure of STING CTT in complex with TBK1 | Descriptor: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | Authors: | Li, P, Zhao, B, Du, F. | Deposit date: | 2019-03-09 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature, 569, 2019
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6O8B
| Crystal structure of STING CTD in complex with TBK1 | Descriptor: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | Authors: | Li, P, Zhao, B, Du, F. | Deposit date: | 2019-03-09 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature, 569, 2019
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7JFM
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3EQT
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5JEJ
| Phosphorylated STING in complex with IRF-3 CTD | Descriptor: | Interferon regulatory factor 3, Stimulator of interferon genes protein | Authors: | Li, P, Shu, C. | Deposit date: | 2016-04-18 | Release date: | 2016-06-15 | Last modified: | 2016-06-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc.Natl.Acad.Sci.USA, 113, 2016
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7JFL
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2OTU
| Crystal structure of Fv polyglutamine complex | Descriptor: | Fv heavy chain variable domain, Fv light chain variable domain, peptide antigen | Authors: | Li, P. | Deposit date: | 2007-02-09 | Release date: | 2007-04-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Implications of the structure of a poly-Gln/anti-poly-Gln complex for disease progression and therapy To be Published
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4LEZ
| Structure of mouse cGAS bound to an 18bp DNA and cGAS product | Descriptor: | 18bp dsDNA, Cyclic GMP-AMP synthase, ZINC ION, ... | Authors: | Li, P. | Deposit date: | 2013-06-26 | Release date: | 2013-12-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization. Immunity, 39, 2013
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5HNV
| Crystal structure of PpkA | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Li, P.P, Ran, T.T, Wang, W.W. | Deposit date: | 2016-01-19 | Release date: | 2017-01-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism. Biochem.J., 475, 2018
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3GA3
| Crystal structure of the C-terminal domain of human MDA5 | Descriptor: | Interferon-induced helicase C domain-containing protein 1, MDA5, ZINC ION | Authors: | Li, P. | Deposit date: | 2009-02-16 | Release date: | 2009-02-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal structure of the C-terminal domain of human MDA5 To be Published
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