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6O8B

Crystal structure of STING CTD in complex with TBK1

Summary for 6O8B
Entry DOI10.2210/pdb6o8b/pdb
DescriptorStimulator of interferon genes protein, Serine/threonine-protein kinase TBK1, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide (3 entities in total)
Functional Keywordsadaptor, kinase, complex, immune system
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight205461.57
Authors
Li, P.,Zhao, B.,Du, F. (deposition date: 2019-03-09, release date: 2019-05-22, Last modification date: 2023-10-11)
Primary citationZhao, B.,Du, F.,Xu, P.,Shu, C.,Sankaran, B.,Bell, S.L.,Liu, M.,Lei, Y.,Gao, X.,Fu, X.,Zhu, F.,Liu, Y.,Laganowsky, A.,Zheng, X.,Ji, J.Y.,West, A.P.,Watson, R.O.,Li, P.
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569:718-722, 2019
Cited by
PubMed: 31118511
DOI: 10.1038/s41586-019-1228-x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.4 Å)
Structure validation

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